Diagnostic value of 18F-FDG PET/CT in paediatric neuroblastoma

Dhull, Varun Singh; Sharma, Punit; Patel, Chetan; Kundu, Parveen; Agarwala, Sandeep; Bakhshi, Sameer; Bhatnagar, Veereshwar; Bal, Chandrasekhar; Kumar, Rakesh

doi:10.1097/mnm.0000000000000347

Cited by 29 publications

(15 citation statements)

References 16 publications

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“…In a case study by Colavolpe et al ( 45 ), FDG PET/CT demonstrated utility in monitoring NB following treatment because these tumors can lose MIBG avidity resulting in falsely negative findings. These findings were also seen in the study by Dhull et al ( 44 ).…”

Section: Neuroblastoma (Nb)supporting

confidence: 86%

“…PET imaging also makes use of the significant metabolic activity exhibited by NB tumors and can be useful for NB imaging in cases in which NB does not express sufficient norepinephrine transporter for MIBG uptake or when cost of and/or access to MIBG radiotracer is prohibitive ( 44 ). In a comparative study of fluorine-18 fluorodeoxyglucose ( 18 F-FDG) PET/CT versus 131 I MIBG scintigraphy by Dhull et al ( 44 ), PET/CT was far more sensitive for detection of lymph node metastases. PET/CT detected 22 nodal lesions versus only five seen on 131 I MIBG scintigraphy, P=0.001.…”

Section: Neuroblastoma (Nb)mentioning

confidence: 99%

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Lymph node imaging of pediatric renal and suprarenal malignancies

Gold

Sabarwal

Gordhan

et al. 2018

Transl. Androl. Urol

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Pediatric renal and suprarenal cancers are relatively rare malignancies, but are not without significant consequence to both the patient and caretakers. These tumors are often found incidentally and present as large abdominal masses. Standard of care management involves surgical excision of the mass, but contemporary treatment guidelines advocate for use of neoadjuvant or adjuvant chemotherapy for advanced stage disease, such as those cases with lymph node involvement (LNI). However, LNI detection is based primarily on surgical pathology and performing extended lymph node dissection can add significant morbidity to a surgical case. In this review, we focus on the use and performance of imaging modalities to detect LNI in Wilms’ tumor (WT), neuroblastoma, and pediatric renal cell carcinoma (RCC). We report on how imaging impacts management of these cases and the clinical implications of LNI. A literature search was conducted for studies published on imaging-based detection of LNI in pediatric renal and suprarenal cancers. Further review focused on surgical and medical management of those cases with suspected LNI. Current imaging protocols assisting in diagnosis and staging of pediatric renal and suprarenal cancers are generally limited to abdominal ultrasound and cross-sectional imaging, mainly computed tomography (CT). Recent research has investigated the role of more advance modalities, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), in the management of these malignancies. Special consideration must be made for pediatric patients who are more vulnerable to ionizing radiation and have characteristic imaging features different from adult controls. Management of pediatric renal and suprarenal cancers is influenced by LNI, but the rarity of these conditions has limited the volume of clinical research regarding imaging-based staging. As such, standardized criteria for LNI on imaging are lacking. Nevertheless, advanced imaging modalities are being investigated and potentially represent more accurate and safer options.

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Section: Neuroblastoma (Nb)supporting

confidence: 86%

Section: Neuroblastoma (Nb)mentioning

confidence: 99%

Lymph node imaging of pediatric renal and suprarenal malignancies

Gold

Sabarwal

Gordhan

et al. 2018

Transl. Androl. Urol

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“…FDG, the glucose analogue, is the most widely used non-specific metabolic tracer for clinical imaging in oncology. For the detection of human NB lesions, based on their enhanced intracellular glucose transport and metabolism, FDG PET compared favourably with MIBG scintigraphy (19,20). Even though published evidence is for the moment limited, it has been shown that 68 Ga-DOTATOC is also suited to the detection of human NB lesions, based on the overexpression of SSTR (11); furthermore, this capacity has been well-documented during the past decade for imaging NET.…”

Section: Discussionmentioning

confidence: 99%

68Ga-DOTATOC and FDG PET Imaging of Preclinical Neuroblastoma Models

Provost

Prignon

Cazes

et al. 2016

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“…[ 15 ] In a recent study, FDG-PET was superior to mIBG for detection of lymph nodal and bone/bone marrow lesions. [ 16 ]…”

Section: Iagnosismentioning

confidence: 99%

Advances in the Surgical Treatment of Neuroblastoma

Luo

Cui

Yang

et al. 2018

Chinese Medical Journal

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Objective:This study was to review the efficacy of surgical resections in different clinical situations for a better understanding of the meaning of surgery in the treatment of neuroblastoma (NB).Data Sources:The online database ScienceDirect (2016–2018) was utilized. The search was conducted using the keywords “neuroblastoma,” “neuroblastoma resection,” “neuroblastoma surgery,” and “high-risk neuroblastoma.”Study Selection:We retrospectively analyzed of patients who underwent surgical resections in different clinical situations. The article included findings from selected relevant randomized controlled trials, systematic reviews, and meta-analyses or good-quality observational studies. Abstracts only, letters, and editorial notes were excluded. Full-text articles and abstracts were extracted and reviewed to identify key articles discussing surgery management of NB, which were then selected for critical analysis.Results:A total of 7800 English language articles were found containing references to NB (2016–2018). The 163 articles were searched which were related to the surgical treatment of NB (2016–2018). Through the analysis of these important articles, we found that the treatments of NB at low- and intermediate-risk groups were basically the same. High-risk patients remained controversial.Conclusions:NB prognosis varies tremendously based on the stage and biologic features of the tumor. After reviewing the relevant literature, patients with low-risk disease are often managed with surgical resection or observation alone with tumors likely to spontaneously regress that are not causing symptoms. Intermediate patients are treated with chemotherapy with the number of cycles depending on their response as well as surgical resection of the primary tumor. High-risk patients remain controversial. Multidisciplinary intensive treatment is essential, especially for patients who received subtotal tumor resection. Minimally invasive surgery for the treatment of NBs without image-defined risk factors in low- to high-risk patients is safe and feasible and does not compromise the treatment outcome. We conclude that ≥90% resection of the primary tumor is both feasible and safe in most patients with high-risk NB. New targeted therapies are crucial to improve survival.

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Diagnostic value of 18F-FDG PET/CT in paediatric neuroblastoma

Abstract: 18F-FDG PET/CT shows high accuracy in paediatric patients with NB and demonstrates more lesions as compared with 131I-MIBG scintigraphy.

Cited by 29 publications

References 16 publications

Lymph node imaging of pediatric renal and suprarenal malignancies

Lymph node imaging of pediatric renal and suprarenal malignancies

68Ga-DOTATOC and FDG PET Imaging of Preclinical Neuroblastoma Models

Advances in the Surgical Treatment of Neuroblastoma

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