Diagnostic value and biological significance of antibody-coated bacteria in urine

Mengoli, Carlo; Arosio, E.; Bonato, Donald; Spiazzi, Giovanna; Pancera, P; Montesi, Germana; Lechi, Alessandro; La, Scuro

doi:10.1136/jcp.33.2.183

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Literature on antibody‐coated microorganisms is largely limited to the examination of urinary sediments by direct immunofluorescence, in which a positive result would indicate local production of antibodies in the kidney and support a diagnosis of bacterial or fungal pyelonephritis over a lower urinary tract infection. The urinary pathogens were most frequently coated with IgG and IgA antibodies, similar to the observations in our case 22–24 . Our case also showed strong C3 deposition in the same pattern as the immunoglobulins.…”

Section: Discussionsupporting

confidence: 89%

“…The urinary pathogens were most frequently coated with IgG and IgA antibodies, similar to the observations in our case. [22][23][24] Our case also showed strong C3 deposition in the same pattern as the immunoglobulins. C3 is a complement protein which primarily acts to facilitate immunologic pathogen clearance via increased uptake by phagocytic cells and activation of the adaptive immune response.…”

Section: Discussionsupporting

confidence: 66%

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Detection of antibody‐coatedMucor in skin biopsy by direct immunofluorescence

et al. 2023

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 66%

Detection of antibody‐coatedMucor in skin biopsy by direct immunofluorescence

et al. 2023

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“…In dubious cases, the finding of a local immune response by means of antibody-coated bacteria detection in urine sediment may be a helpful diagnostic tool [23,24]. How ever, in some uncertain cases, the definitive identification of the infection site still requires a long-term follow-up.…”

Section: Resultsmentioning

confidence: 99%

Contribution of Four Markers of Tubular Proteinuria in Detecting Upper Urinary Tract Infections

Mengoli

Lechi

Arosio

et al. 1982

Nephron

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The presence of tubular involvement, as a marker for the detection of urinary tract infection (UTI) site, was examined in 19 patients with pyelonephritis and in 15 patients with cystitis or asymptomatic bacteriuria. The urinary excretion of four markers of tubular proteinuria, β₂-microglobulin (β₂M), lysozyme (LZ), lactic dehydrogenase isoenzyme V (LAD-5) and N-acetyl-βD-glucosaminidase (NAG), was investigated. LAD-5 appeared particularly valuable for the early detection of upper UTI. However, the overall diagnostic accuracy appeared to be further strengthened using, besides LAD-5, one additional variable. A set of simple and noninvasive biochemical tests on urine samples can reliably help to identify the site of UTI.

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“…Antibody-coated bacteria (ACB) in urine sediment have been found mainly in pyelonephritic patients [4][5][6]; however, they have also been demonstrated in connection with lower urinary tract infection [7][8][9]. It was the aim of the present study to follow the appearance of bacteriuria after insertion of an indwelling urinary catheter in elderly patients without a history or signs of urinary tract infec tion.…”

Section: Introductionmentioning

confidence: 99%

Prospective Study on the Appearance of Antibody-Coated Bacteria in Patients with an Indwelling Urinary Catheter

Kostiala¹,

Nyrén²,

Jokinen³

et al. 1982

Nephron

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Elderly patients without urinary tract infection were given prophylactic medication with nitrofurantoin (NF) or methenamine hippurate (MH) because of need for an indwelling urinary catheter. Within 2 weeks of catheter use, all 31 controls without medication had significant bacteriuria; in the MH group (29 patients) 77% and in the NF group (26 patients) 58% were infected. Within 6 weeks virtually all the patients had bacteriuria. Antibody-coated bacteria (ACB) in the urine sediment were found in the minority of patients when bacteriuria first appeared; at 1 week, 50% of controls had ACB, whereas in the NF group this level of positivity was reached after 3 weeks. However, by 5 weeks approximately 70% > of patients in all groups had ACB. The mean time until ACB test positivity after the appearance of bacteriuria was 1.7 weeks in the controls and 2.2 weeks in the MH group; in the NF group it was significantly longer (4.6 weeks). Prophylactic treatment of patients with an indwelling urinary catheter delayed the appearance of bacteriuria and ACB; however, their appearance could not be prevented even by NF.

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Diagnostic value and biological significance of antibody-coated bacteria in urine

Cited by 8 publications

References 18 publications

Detection of antibody‐coatedMucor in skin biopsy by direct immunofluorescence

Detection of antibody‐coatedMucor in skin biopsy by direct immunofluorescence

Contribution of Four Markers of Tubular Proteinuria in Detecting Upper Urinary Tract Infections

Prospective Study on the Appearance of Antibody-Coated Bacteria in Patients with an Indwelling Urinary Catheter

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