Diagnostic value and accuracy of imprint cytology evaluation during image‐guided core needle biopsies: Review of our experience at a large academic center

Kubik, Melanie J.; Bovbel, Alexandra; Goli, Harish; Saremian, Jinous; Siddiqi, Anwer; Masood, Shahla

doi:10.1002/dc.23300

Cited by 29 publications

(21 citation statements)

References 13 publications

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“…In contrast to the majority of surgical specimens, cytological material enables immediate onsite assessment (rapid on site evaluation), which may improve the diagnostic yield and specimen adequacy. Rapid on site evaluation can also be done with touch imprint of core biopsies [56]. Cytological material contains less stromal and other cellular contaminations, compared to histological sections.…”

Section: Discussionmentioning

confidence: 99%

Cell Block in Cytological Diagnostics: Review of Preparatory Techniques

Krogerus

Kholová

2018

Acta Cytologica

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Objective: The cell block (CB) technique refers to the processing of sediments, blood clots, or grossly visible tissue fragments from cytological specimens into paraffin blocks that can be cut and stained by the same methods used for histopathology. The technique brings additional tissue architectural information. CB can be used for ancillary techniques such as immunocytochemistry and molecular techniques. Study Design: We reviewed the literature on the various preparatory techniques of CBs. Results: There is a wide range of preparatory techniques for CBs and no golden standard for CBs exists: tens of methods are used in various institutions. The majority of the methods are modified in house techniques with a few commercially available kits. The techniques most commonly used are the plasma/thrombin method, the agar method, and commercially available Histogel- and Cellient CB-methods. Dissatisfaction with the cellular yield of the CBs is common. Conclusions: In the CBs, the cytological material is preserved for future use, which is a tremendous advantage in the era of targeted therapy and biobanking. The CB is thus central to the future of cytology: more can be done with less material and with less invasiveness to the patient.

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Section: Discussionmentioning

confidence: 99%

Cell Block in Cytological Diagnostics: Review of Preparatory Techniques

Krogerus

Kholová

2018

Acta Cytologica

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“…Given that ROSE is a widely used technique, different evaluation criteria have been proposed to determine specimen suitability for samples obtained by EBUS-TBNA, e.g . amount of lymphoid elements, presence of polluting bronchial cells, number of pigmented macrophages, amount of necrosis and presence of mucus and blood [15–18]. Jeffus et al performed a comparison between Minnesota and New York criteria to establish the adequacy of EBUS-TBNA specimens [15], while Idowu and Powers analyzed the cytomorphological characteristics of primary lung cancers.…”

Section: Introductionmentioning

confidence: 99%

Easily detectable cytomorphological features to evaluate during ROSE for rapid lung cancer diagnosis: from cytology to histology

et al. 2016

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In lung cancer patients, the only available diagnostic material often comes from biopsy or from cytological samples obtained by fine needle aspiration (FNA). There is a lack of easily detectable cytomorphological features for rapid on-site evaluation (ROSE) to orient lung cancer diagnosis towards a specific tumor histotype. We studied the cytological features evaluated on site to define tumor histotype and to establish the number of specimens to be taken. Cytological specimens from 273 consecutive patients were analyzed with ROSE: bronchoscopy with transbronchial needle aspiration (TBNA) had been performed in 72 patients and with endobronchial ultrasound (EBUS)-TBNA in 201. Cytomorphological features were correlated with the final diagnosis and diagnostic accuracy was measured. Analysis of the different cytomorphological parameters showed that the best sensitivity and specificity were obtained for adenocarcinoma by combining the presence of nucleoli and small/medium cell clusters, and for squamous cell carcinoma by considering the presence of necrosis ≥50% and large cell clusters. For small cell carcinoma, the best diagnostic accuracy was obtained by combining moderate necrosis (<50%) and the presence of single cells. Overall accuracy ranged from 90% to 97%. We showed that it was possible to establish the histotype of the most frequent lung cancers during ROSE using only a few easily identifiable cytomorphological parameters. An accurate diagnosis during ROSE could help endoscopists to decide how many tumor samples must be taken, e.g.a higher number of samples is needed for the biomolecular characterization of adenocarcinoma, whereas one sample may be sufficient for squamous cell carcinoma.

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“…Kubiket. al [1] has studied the utility of touch imprint cytology as an adjunct to core needle biopsies of tumors of various sites such as lungs, liver, prostate and found a diagnostic accuracy of 91 %. Another similar study by Moghadamfalahi et.al.…”

Section: Discussionmentioning

confidence: 99%

“…Touch imprint cytology has also been used for diagnosis of cancers of various sites [1,2], evaluation of sentinel lymph node biopsy [3] an intraoperative procedure and post mortem studies [4]. In this study we intend to evaluate the efficacy of touch imprint cytology in assessment of adequacy of needle core biopsy of breast lumps and to assess its diagnostic accuracy for the presence of malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Utility of touch imprint cytology as an adjunct to core needle biopsy of breast lump

Mohanty¹

2016

J Res Med Den Sci

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Background: Touch imprint cytology is an easy and rapid method of evaluation of cancers. It can be utilized as a rapid intraoperative method and on site evaluation of biopsy specimen. Aim: to evaluate the efficacy of touch imprint cytology in assessment of adequacy of needle core biopsy of breast lumps its diagnostic accuracy for malignancy. Material and methods: A total of 160 cases of core needle biopsies of breast lump were studied. In each case touch imprint were made and a cytological diagnosis was offered on site. The results were correlated with the final biopsy diagnosis. Results: Adequate and satisfactory material on touch imprint was obtained in 154 (96.3%) cases.A total of 132 (82.5 %) cases were diagnosed as malignant and 21 (13.1 %) cases were diagnosed as benign on touch imprint cytology. Three cases (1.9%) were inconclusive, as the cells were obscured with inflammatory cells or there were crush artefacts. Overall sensitivity of TIC was 98.3 %, specificity was 70.3 %, positive predictive value was 93.8 %, negative predictive value was 90.4 % and accuracy was 90.2%. In 135 (88.2%) cases, a specific diagnosis regarding the exact histological subtype of the breast lesion could be provided. Conclusions: Touch imprint cytology of core needle biopsy specimens of breast lump yields adequate and satisfactory diagnostic material. It can be used routinely at the site of biopsy to evaluate the adequacy of material obtained during core needle biopsy. Touch imprints gives rapid and fairly accurate diagnosis of malignancy and subtyping of tumor is also possible.

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Diagnostic value and accuracy of imprint cytology evaluation during image‐guided core needle biopsies: Review of our experience at a large academic center

Cited by 29 publications

References 13 publications

Cell Block in Cytological Diagnostics: Review of Preparatory Techniques

Cell Block in Cytological Diagnostics: Review of Preparatory Techniques

Easily detectable cytomorphological features to evaluate during ROSE for rapid lung cancer diagnosis: from cytology to histology

Utility of touch imprint cytology as an adjunct to core needle biopsy of breast lump

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