Diagnostic Validity of Optic Disc and Retinal Nerve Fiber Layer Evaluations in Detecting Structural Changes after Optic Neuritis

Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no history of optic neuritis identified by the use of spectral domain high-definition optical coherence tomography

“…9,16 A functional correlation to this observation was identified by Pueyo et al by demonstrating that VEP P100 latencies were prolonged and amplitudes decreased -mainly in the temporal quadrant -in MS patients without a history of ON. 16 Another study by Bertuzzi et al,2 found no correlation between RNFL thickness and VEP latencies, but found a significant correlation with the VEP amplitudes. Previous reports of similar findings 9,16 have been conducted with technologies different from HD-OCT such as timedomain OCT and scanning laser polarimetry (GDx).…”

“…It can be identified as thinning of the retinal nerve fiber layer (RNFL) through computerized imaging technologies such as optical coherence tomography (OCT). 2 OCT is a non-invasive, simple-to-use, cost-effective tool, which provides in vivo cross-sectional images of the retina using the reflectivity of light waves. It can identify loss of the peripapillary RNFL, optic disc and macular thickness.…”

Optical Coherence Tomography in Multiple Sclerosis and Neuromyelitis Optica: An Update

“…Prospective studies estimate that there is a 20 to 25% loss in the RNFL thickness when compared to the fellow unaffected eye (Table 1) [5, 6, 8]. The decrease is greater in Asian patients whose visual function is damaged more severely [4].…”

“…The decrease is greater in Asian patients whose visual function is damaged more severely [4]. Most studies have been unable to demonstrate a significant thinning of the RNFL of the fellow eyes when compared to healthy controls [8–11]. …”

“…This loss may be detected as soon as two months after the event, when compared to the fellow eye and healthy controls [4, 7, 8]. Temporal thickness decreases between 25 and 34% [5, 8, 12]. This reflects a predominant affectation of the papillomacular bundle, which conveys the information from the fovea, the central macular structure mainly responsible for detailed visual and color functions.…”