Diagnostic utility of DTI in prostate cancer

Gürses, Bengı; Taşdelen, Neslihan; Yencilek, Faruk; Kılıckesmez, N. Ozgür; Alp, Turgut; Fırat, Zeynep; Albayrak, Mevlüt; Uluğ, Aziz M.; Gürmen, Ahmet Nevzat

doi:10.1016/j.ejrad.2010.01.009

Cited by 42 publications

(43 citation statements)

References 16 publications

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“…This technique is widely used for imaging in the central nervous system and skeletal muscle system (15,16); however, the use of DTI for the diagnosis, classification and evaluation of PCa remains unknown (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

et al. 2017

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Abstract. The aim of the present study was to explore the association between the parameters of diffusion tensor imaging (DTI), including fractional anisotropy (FA) values, apparent diffusion coefficient (ADC) values and the diffusion tensor tractography (DTT) map, with the Gleason score of prostate cancer (PCa). A retrospective study of 50 cases of PCa confirmed by biopsy or surgical pathology was performed. Conventional magnetic resonance imaging and DTI scans were conducted in these cases. The 50 cases of PCa were divided into three groups, including low, intermediate and high grade, according to the Gleason score. Post-DTI processing was performed using Neuro 3D software, in order to measure the FA and ADC values, and map the prostate fibers. Differences in FA and ADC values among the various PCa groups were examined using analysis of variance, while the correlation of FA and ADC values with the Gleason score was studied using Pearson correlation analysis. The obtained DTT map clearly demonstrated the spatial structure of the prostate fibers. The fibers of the cancer area were dense without interruption in the low-grade group, sparse and disordered in the intermediate-grade group, and were disordered, sparse or even absent in the high-grade group. The FA values were 0.284±0.313, 0.293±0.347 and 0.369±0.347, respectively, with statistically significant differences observed among the three groups (F=234.533; P<0.05) and between each group (P<0.05). In addition, the FA value of PCa was positively correlated with the Gleason score (r=0.884; P<0.05). The ADC values of the low-, intermediate-and high-grade groups were 1.070±0.072x10 , respectively, which demonstrated statistically significant differences among the three groups (F=49.987; P<0.05) and between each group (P<0.05). Furthermore, the ADC values of PCa were negatively correlated with Gleason score (r=-0.810; P<0.05). In conclusion, there was an association between DTI parameters and Gleason score, which may be used to evaluate the grading and prognosis of PCa.

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Section: Discussionmentioning

confidence: 99%

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

et al. 2017

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“…This property of DTI enables the evaluation of anisotropy and provides more detailed data regarding the diffusion of water in various tissues (12,14,15). DWI and DTI have been used to examine a variety of intra-abdominal organs, including the liver, kidneys, and pelvic organs (7,8,12,15). With respect to the adrenal gland, only DWI data have been published (5,11,16).…”

Section: Discussionmentioning

confidence: 99%

“…Feasibility studies of DTI in the kidney using 3 T MRIs have also been performed (12,15,17), and DTI has been shown to be beneficial in the differentiation of prostate cancer and chronic prostatitis (18). To the best of our knowledge, the adrenals have not previously been examined using DTI.…”

Section: Discussionmentioning

confidence: 99%

“…DTI is used to evaluate the anisotropic features of tissues and allows the analysis of diffusion in at least six different directions. This property of DTI enables the evaluation of anisotropy and provides more detailed data regarding the diffusion of water in various tissues (12,14,15). DWI and DTI have been used to examine a variety of intra-abdominal organs, including the liver, kidneys, and pelvic organs (7,8,12,15).…”

Section: Discussionmentioning

confidence: 99%

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Diffusion tensor imaging in the differentiation of adrenal adenoma and metastases

Işık

Gürses²,

Taşdelen³

et al. 2011

Diagn Interv Radiol

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“…Although exclusion of patients with histology of prostatitis from our analysis may well have improved the significance of our findings, it would not have addressed the issue of random histological sampling, so this was not considered as an exclusion criterion. Preliminary data suggest that techniques such as diffusion tensor imaging can aid in distinguishing prostatitis from tumour [28], so inclusion of ADC directionality in future studies could improve the accuracy of tumour delineation. Finally, we did not control the timing of biopsy.…”

Section: Discussionmentioning

confidence: 99%

Relationship betweenT₂relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume

Simpkin

Morgan²,

Giles³

et al. 2013

BJR

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Objective: To establish whether T 2 relaxation and apparent diffusion coefficient (ADC) in normal prostate and tumour are related and to investigate the effects of glandular compression from an enlarged transition zone (TZ) on peripheral zone (PZ) T 2 and ADC by correlating them with the peripheral zone fractional volume (PZFV).Methods: 48 consecutive patients prospectively underwent multiecho T 2 weighted (T 2 W) (echo times 20, 40, 60, 80, 100 ms) and diffusion-weighted (b50, 100, 300, 500, 800 s mm 22 ) endorectal MRI. In 43 evaluable patients, single slice whole PZ, TZ and tumour (focal hypointense signal on T 2 W images in a biopsy-positive octant) regions of interest were transferred to T 2 and ADC maps by slice matching. T 2 and ADC values were correlated, and PZ values were correlated with PZFV.

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Diagnostic utility of DTI in prostate cancer

Cited by 42 publications

References 16 publications

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

Diffusion tensor imaging in the differentiation of adrenal adenoma and metastases

Relationship betweenT₂relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume

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Diagnostic utility of DTI in prostate cancer

Cited by 42 publications

References 16 publications

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

Correlation of diffusion tensor imaging parameters and Gleason scores of prostate cancer

Diffusion tensor imaging in the differentiation of adrenal adenoma and metastases

Relationship betweenT2relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume

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Product

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Relationship betweenT₂relaxation and apparent diffusion coefficient in malignant and non-malignant prostate regions and the effect of peripheral zone fractional volume