Diagnostic utility of aquaporin-4 blood level in neonatal hypoxic ischemic encephalopathy

Diagnostic Utility of Aquaporin-4 blood level in Neonatal Hypoxic Ischemic Encephalopathy

“…The present study revealed that at day 7, the mean AQP4 was significantly increased in infants took 3 anti-convulsion therapy in comparison with infants took 2 anticonvulsions in comparison with neonates took single anti-convulsion therapy compared with infants didn't receive any anti-convulsion drug (965.5±173.6 vs. 879.5±125.5 versus 817.2±96.2 versus 800±166.8, respectively). Such findings agreed with Elbanna et al (27) that demonstrated that the mean AQP4 was significantly increased in babies received three kinds of anticonvulsants in comparison with those received 1 type of anticonvulsants compared with neonates who did not receive anticonvulsant agents (524.70 ± 47.19 vs. 373.32 ± 62.44 vs. 243.01± 22.80, respectively) (P value<0.001).…”

“…That could be explained by Clément et al (26) who concluded that AQP4 has pivotal roles in inducing brain oedema in HIE. Such findings agreed with Elbanna et al (27) that assessed the blood levels of AQP4 in thirty neonates with HIE and thirty babies not suffering HIE and demonstrated that the mean AQP4 at age of 2 days was found to be significantly elevated in hypoxic cases in comparison the control (220.83±98.85 vs. 135.51± 28.32 pg/ml). furthermore, the mean levels of AQP4 at 7 th day among cases group was further elevation reaching 349.72±110.25 pg/ml.…”

“…A previous study by Elbanna et al (27) detected that the cut-off value of serum levels of AQP4 were 158 pg/ml, with sensitivity of 66.7 percent, specificity of 73.3 percent, and 95% of accuracy.…”