Diagnostic usefulness of 18F-FDG PET/CT in the differentiation of pulmonary artery sarcoma and pulmonary embolism

Ito, Kimiteru; Kubota, Keiichi; Morooka, Miyako; Shida, Yoshitaka; Kanehiro, Hiromichi; Endo, Hisako; Matsuda, Hiroshi

doi:10.1007/s12149-009-0292-y

Cited by 98 publications

(72 citation statements)

References 16 publications

(21 reference statements)

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“…In this case, FDG-PET and chest radiography were useful in a diagnostic workup, as has been reported elsewhere. 4 There is no specifi c guideline on the management of pulmonary artery sarcomas. The standard therapeutic procedure is surgical resection with adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary artery intimal sarcoma: the role of 18F-fluorodeoxyglucose positron emission tomography in monitoring response to treatment

et al. 2011

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We report the case of 58-year-old man with pulmonary artery intimal sarcoma. He initially presented with cough, right-sided chest pain, and shortness of breath. Although the diagnosis of pulmonary embolism had been considered, chest radiograph and pulmonary perfusion scintigraphy showed a mass in the right hilum and no perfusion in the right lung. (18)F-fluorodeoxyglucose positron emission computed tomography (FDGPET) showed increased FDG uptake in the mass obstructing the right pulmonary artery. Fine-needle biopsy revealed a pathological diagnosis of pulmonary artery intimal sarcoma. The patient was successfully treated with radiotherapy and adjuvant chemotherapy. FDG-PET was used for monitoring the response to therapy.

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Section: Discussionmentioning

confidence: 99%

“…Recently, the diagnostic usefulness of 18 F-fl uorodeoxyglucose (FDG)-PET in differentiating pulmonary artery sarcoma and pulmonary embolism has been reported. 4 We describe the case of a pulmonary arterial intimal sarcoma that underwent serial FDG-PET studies for monitoring the therapeutic response.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary artery intimal sarcoma: the role of 18F-fluorodeoxyglucose positron emission tomography in monitoring response to treatment

et al. 2011

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“…Multiple PET findings have been described in association with pulmonary emboli, including pulmonary artery hypermetabolism (13,(22)(23)(24), four-chamber cardiac uptake (25), and the presence of a rim of hypermetabolism surrounding a pulmonary infarction (26,27). However, the relative frequency of these findings has not been previously described.…”

Section: Discussionmentioning

confidence: 99%

“…We found that focal pulmonary arterial hypermetabolism could only be qualitatively detected in 15.2% of cases, indicating that this is an insensitive secondary sign of PE. The differential diagnosis for the finding of pulmonary arterial hypermetabolism includes pulmonary artery sarcoma, pulmonary artery metastasis, and FDG microembolism secondary to paravenous injection (23,24,28). These should be readily distinguishable because of the much higher SUV reported for pulmonary artery malignancies, and because of the presence of extravasation of FDG at the injection site in the case of microembolism.…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Pulmonary Embolism and Associated FDG-PET Findings in IV Contrast-Enhanced PET/CT

et al. 2014

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Rationale and Objectives: Most fluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography with computed tomography (PET/ CT) studies are performed on cancer patients. These patients are at increased risk of pulmonary embolism (PE). In this retrospective review, we determined the rate of PE, and the prevalence of associated FDG-PET findings on intravenous (IV) contrast-enhanced PET/CT. Materials and Methods:We identified all PET/CT studies performed at our institution with a reported finding of PE between January 2005 and October 2012. The medical record was reviewed for symptoms, which were identified after the diagnosis of PE, and whether the patients received treatment. The prevalence of associated FDG-PET findings was determined.Results: A total of 65 total cases of PE (of 182,72 total PET/CT examinations) were identified of which 59 were previously unknown. This gives an incidental PE (IPE) rate of 0.32%. Of the patients where sufficient clinical information was available, 34 of 36 (94%) were treated either with therapeutic anticoagulation or inferior vena cava filter, and 30 of 36 (83%) were asymptomatic in retrospect. Of the patients with IPE, we found nine (15.2%) with associated focal pulmonary artery hypermetabolism, three (5.1%) with hypermetabolic pulmonary infarction, and one with increased isolated right ventricular FDG uptake (1.7%). One case of chronic PE demonstrated a focal hypometabolic filling defect in a pulmonary artery on PET. Conclusions:We found IPE in 0.32% of PET/CT scans. Focal pulmonary artery hypermetabolism or hypometabolism, and hypermetabolic pulmonary artery infarction with the ''rim sign'' were uncommonly associated with PE. These findings could raise the possibility of IPE in non-IV contrast-enhanced PET/CT studies.

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“…Details of the FDG PET/CT procedure have been previously described [19,22]. Patients fasted overnight for at least 4 h, and normal blood glucose level was confirmed before FDG injection.…”

Section: Fdg Pet/ct Examinationmentioning

confidence: 99%

18F-Fluorodeoxyglucose positron emission tomography optimizes neoadjuvant chemotherapy for primary breast cancer to achieve pathological complete response

et al. 2011

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Diagnostic usefulness of 18F-FDG PET/CT in the differentiation of pulmonary artery sarcoma and pulmonary embolism

Abstract: FDG PET/CT could distinguish pulmonary artery sarcoma from pulmonary embolism based on the SUV(max) value.

Cited by 98 publications

References 16 publications

Pulmonary artery intimal sarcoma: the role of 18F-fluorodeoxyglucose positron emission tomography in monitoring response to treatment

Pulmonary artery intimal sarcoma: the role of 18F-fluorodeoxyglucose positron emission tomography in monitoring response to treatment

The Incidence of Pulmonary Embolism and Associated FDG-PET Findings in IV Contrast-Enhanced PET/CT

18F-Fluorodeoxyglucose positron emission tomography optimizes neoadjuvant chemotherapy for primary breast cancer to achieve pathological complete response

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