Diagnostic Use of Snake Venom Components in the Coagulation Laboratory

Perchuc, Anna Maria; Wilmer, Marianne

doi:10.1007/978-90-481-9295-3_43

Cited by 11 publications

(11 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28,29 Both molecules are used as diagnostic agents for testing receptor-specific disorders. 30 Some other snaclecs inhibit platelet aggregation. For instance, flavocetin-A from the habu snake Protobothrops flavoviridis (formerly Trimeresurus flavoviridis) binds GPIb and inhibits the interaction between VWF and its receptor GPIb/IX/V complex.…”

Section: Inhibitors Of Collagen or Von Willebrand Factor Receptorsmentioning

confidence: 99%

“…RVV-X is used as a diagnostic agent for clotting factor disorders through the Stypven time assay. 30 Activators of prothrombin from snake venom can be divided into four groups: groups A and B, which are metalloproteases, and groups C and D, which are serine proteases. 90 Ecarin, a group A prothrombin activator, is used to perform the Ecarin time, a clotting assay commonly used for the drug monitoring of direct thrombin inhibitors.…”

Section: Figmentioning

confidence: 99%

“…90 Ecarin, a group A prothrombin activator, is used to perform the Ecarin time, a clotting assay commonly used for the drug monitoring of direct thrombin inhibitors. 30 Group C and D prothrombin activators are structural and functional homologues of the mammalian FXa-Va complex and FXa enzyme, respectively. 87 Haempatch is a group D prothrombin activator from the brown snake Pseudonaja textilis developed as a topical hemostatic agent to treat blood loss.…”

Section: Figmentioning

confidence: 99%

“…175 Batroxobin is also used to perform Reptilase time, a clotting assay used to detect abnormalities in fibrinogen. 30…”

Section: Defibrinogenating Agentsmentioning

confidence: 99%

See 3 more Smart Citations

Toxins Are an Excellent Source of Therapeutic Agents against Cardiovascular Diseases

Koh

Modahl

Kulkarni

et al. 2018

Semin Thromb Hemost

View full text Add to dashboard Cite

Venomous and hematophagous animals use their venom or saliva for survival, to obtain food, and for self-defense. Venom and saliva from these animals are cocktails of bioactive molecules primarily composed of proteins and peptides. These molecules are called toxins because they cause unwanted consequences on prey. They exhibit unique, diverse, and specific biological activities that perturb normal physiological processes of their prey and host. However, the potential of toxins as inspirations for the development of therapeutic agents or pharmacological tools has also long been recognized. In addition to their small size, the exquisite selectivity and structural stability of toxins make them attractive as starting molecule in the development of therapeutic and diagnostic agents. Drug discovery and development from venomous and hematophagous animals against cardiovascular diseases have been particularly successful. Some of the notable success include antihypertensive (captopril and enalapril) and antiplatelet agents (tirofiban and eptifibatide), as well as anticoagulants (lepirudin and bivalirudin). Highlighted in this review are many venom or saliva-derived cardiovascular-active proteins and peptides of therapeutic interest, including those that are currently in preclinical stages and those that have been approved by FDA and currently in the market. The authors attempt to summarize their structure, function, mechanism of action, and development with respect to cardiovascular diseases.

show abstract

Section: Inhibitors Of Collagen or Von Willebrand Factor Receptorsmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

“…175 Batroxobin is also used to perform Reptilase time, a clotting assay used to detect abnormalities in fibrinogen. 30…”

Section: Defibrinogenating Agentsmentioning

confidence: 99%

See 2 more Smart Citations

Toxins Are an Excellent Source of Therapeutic Agents against Cardiovascular Diseases

Koh

Modahl

Kulkarni

et al. 2018

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…Some proteins, such as Ancrod [105], have been clinically used in its native form, but the majority of procoagulant snake venom toxins have been used as reagents in laboratory tests and diagnostic kits [107]. The use of exogenous factors as therapeutic products need the approvals of several regulatory procedures that delay the time between research, development and production; not to mention the costs and efforts involving intellectual property.…”

Section: Limitations Of Exogenous Procoagulant Factors In Diagnostic mentioning

confidence: 99%

Exogenous Procoagulant Factors as Therapeutic and Biotechnological Tools

Chudzinski-Tavassi

Carvalho²,

Andrade³

et al. 2014

J Blood Disord Transfus

View full text Add to dashboard Cite

White (2005) listed the snakes of medical importance that affect the hemostatic system. The venom of these reptiles can cause several types of coagulopathy including procoagulant and anticoagulant actions, fibrinogen clotting, fibrinolysis, platelet-activation, prothrombotic and hemorrhagic states [14]. A diversity of toxins from snake venoms has been described: hemorragins, clotting factor activators, clotting

show abstract