Diagnostic use of fine‐needle aspiration cytology and core‐needle biopsy in head and neck sarcomas

Sheppard, Sean C.; Borner, Urs; Wartenberg, Martin; Giger, Roland; Nisa, Lluís

doi:10.1002/hed.26670

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…The HNC diagnosis usually includes laryngoscopy, imaging [Positron emission tomography/X-ray computed tomography (PET/CT) and magnetic resonance imaging (MRI)], and biopsy of the primary lesion [ 31 , 32 , 33 , 34 , 35 ]. As technology progresses, the development of non-invasive diagnostic tools in the field of head and neck oncology has been examined; the molecular analysis of tumor’s genetic features based on circulating malignance derivatives, such as circulating tumor DNA, intact circulating tumor cells (CTCs), and exosomes in patients’ blood, namely liquid biopsy, has become a concrete possible approach to improve diagnostics, treatment planning, and post-treatment surveillance in patients with the potentially curable disease [ 36 , 37 , 38 , 39 ].…”

Section: Head and Neck Cancer And Alcoholmentioning

confidence: 99%

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

et al. 2022

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Head and neck cancer (HNC) concerns more than 890,000 patients worldwide annually and is associated with the advanced stage at presentation and heavy outcomes. Alcohol drinking, together with tobacco smoking, and human papillomavirus infection are the main recognized risk factors. The tumorigenesis of HNC represents an intricate sequential process that implicates a gradual acquisition of genetic and epigenetics alterations targeting crucial pathways regulating cell growth, motility, and stromal interactions. Tumor microenvironment and growth factors also play a major role in HNC. Alcohol toxicity is caused both directly by ethanol and indirectly by its metabolic products, with the involvement of the oral microbiota and oxidative stress; alcohol might enhance the exposure of epithelial cells to carcinogens, causing epigenetic modifications, DNA damage, and inaccurate DNA repair with the formation of DNA adducts. Long-term markers of alcohol consumption, especially those detected in the hair, may provide crucial information on the real alcohol drinking of HNC patients. Strategies for prevention could include food supplements as polyphenols, and alkylating drugs as therapy that play a key role in HNC management. Indeed, polyphenols throughout their antioxidant and anti-inflammatory actions may counteract or limit the toxic effect of alcohol whereas alkylating agents inhibiting cancer cells’ growth could reduce the carcinogenic damage induced by alcohol. Despite the established association between alcohol and HNC, a concerning pattern of alcohol consumption in survivors of HNC has been shown. It is of primary importance to increase the awareness of cancer risks associated with alcohol consumption, both in oncologic patients and the general population, to provide advice for reducing HNC prevalence and complications.

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Section: Head and Neck Cancer And Alcoholmentioning

confidence: 99%

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

et al. 2022

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“…Age, primary site, progression speed and imaging findings strongly support an accurate pathological diagnosis. A close dialogue between the clinician and the pathologist is important in enhancing diagnostic accuracy ( 30 , 31 ).…”

Section: Changes In Histopathological Diagnosis In the Genomic Eramentioning

confidence: 99%

Current topics and management of head and neck sarcomas

Kobayashi

Hanai

Yoshimoto

et al. 2023

Japanese Journal of Clinical Oncology

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Given the low incidence, variety of histological types, and heterogeneous biological features of head and neck sarcomas, there is limited high-quality evidence available to head and neck oncologists. For resectable sarcomas, surgical resection followed by radiotherapy is the principle of local treatment, and perioperative chemotherapy is considered for chemotherapy-sensitive sarcomas. They often originate in anatomical border areas such as the skull base and mediastinum, and they require a multidisciplinary treatment approach considering functional and cosmetic impairment. Moreover, head and neck sarcomas may exhibit different behaviour and characteristics than sarcomas of other areas. In recent years, the molecular biological features of sarcomas have been used for the pathological diagnosis and development of novel agents. This review describes the historical background and recent topics that head and neck oncologists should know about this rare tumour from the following five perspectives: (i) epidemiology and general characteristics of head and neck sarcomas; (ii) changes in histopathological diagnosis in the genomic era; (iii) current standard treatment by histological type and clinical questions specific to head and neck; (iv) new drugs for advanced and metastatic soft tissue sarcomas; and (v) proton and carbon ion radiotherapy for head and neck sarcomas.

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“…FNAC is a minimally invasive way of obtaining diseased tissue and has achieved widespread application in the diagnosis of many sites and types of tumors (6)(7)(8). Combined with various assistive techniques, the correctness of the FNAC diagnosis is comparable to that of histopathological biopsy for some kinds of tumors (6,9). FNAC of suspicious lymph nodes also provides additional information on tumor staging, which can better guide subsequent treatment (10, 11).…”

mentioning

confidence: 99%

Case report: Lymph node metastasis of pelvic alveolar rhabdomyosarcoma diagnosed by fine needle aspiration cytology

Hu,

Huang,

et al. 2024

Front. Oncol.

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Rhabdomyosarcoma (RMS) is a common soft tissue malignant tumor, especially in young patients. Alveolar rhabdomyosarcoma (ARMS) is a subtype of RMS that is prevalent in adolescents. This malignant tumor usually develops in the extremities and can also involve the trunk, perineum, and pelvis. Now, we report a rare case of pelvic lymph node metastatic alveolar RMS in a young patient, which was determined by fine needle aspiration cytology (FNAC). To the best of our knowledge, this is the first case in which the definite diagnosis of ARMS was initially made by FNAC.

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Diagnostic use of fine‐needle aspiration cytology and core‐needle biopsy in head and neck sarcomas

Cited by 4 publications

References 38 publications

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Current topics and management of head and neck sarcomas

Case report: Lymph node metastasis of pelvic alveolar rhabdomyosarcoma diagnosed by fine needle aspiration cytology

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