Orofacial pain (OFP) occurs due to multiple causes, and hence, it is a broad term which comprises of various diseases of orofacial structures, central nervous system or peripheral or psychological abnormality, intracranial pathology, rheumatoid disease, or generalized musculoskeletal disease, or it can be a referred pain from cervical muscles. It is a great challenge for clinicians to deal with all these conditions, as the response to the same noxious stimulus varies from individual to individual. Therefore, to provide an appropriate and optimal treatment, the clinician should acquire a thorough knowledge to make a proper diagnosis. Thereby, this article puts some light on the information related to OFP and an insight into its differential diagnoses.