Diagnostic tests for Cushing's syndrome differ from published guidelines: data from ERCUSYN

Valassi, Elena; Franz, Holger; Brue, Thierry; Feelders, Richard A; Netea‐Maier, Romana T.; Tsagarakis, Stylianos; Webb, Susan M.; Yaneva, Maria; Reincke, Martín; Droste, Michael; Komerdus, Irina; Maiter, Dominique; Kaštelan, Darko; Chanson, Philippe; Pfeifer, Marija; Strasburger, Christian J.; Tóth, Miklós; Chabre, Olivier; Tabarin, Antoine; Kršek, Michal; Fajardo, Carmen; Bolanowski, Marek; Santos, Alicia; Wass, John; Trainer, Peter

doi:10.1530/eje-16-0967

Cited by 57 publications

(58 citation statements)

References 49 publications

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“…One-thousand three hundred forty-one patients with Cushing's syndrome (CS), included into the ERCUSYN database between January 1, 2000 and January 31, 2016, were analyzed (10). Patients were classified into four major groups: pituitary-dependent CS (PIT-CS), adrenaldependent (ADR-CS; adrenal adenoma), CS from an ectopic source (ECT-CS) and CS from other etiologies (OTH-CS).…”

Section: Description Of the Databasementioning

confidence: 99%

“…Of 1341 patients included, 904 (67%) had PIT-CS, 335 (25%) had ADR-CS, 80 (6%) had ECT-CS and 22 (2%) had OTH-CS. Specific etiologic information has been described in detail elsewhere (10). Briefly, 79% of patients were women, median age was 44 years (IQR, 21 years), and median time elapsed from clinical onset to diagnosis was 2 years (IQR, 3 years) (10).…”

Section: General Characteristics Of the Overall Populationmentioning

confidence: 99%

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Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN

Valassi

Franz²,

Brue

et al. 2018

European Journal of Endocrinology

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Section: Description Of the Databasementioning

confidence: 99%

Section: General Characteristics Of the Overall Populationmentioning

confidence: 99%

Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN

Valassi

Franz²,

Brue

et al. 2018

European Journal of Endocrinology

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“…As will be focused in the present review, the use of LNSC measurements, a simple test that evaluates the presence or absence of cortisol circadian rhythm, in the screening of Cushing's syndrome has increased over time (154).…”

Section: :1 R10 Reviewmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: A sense of time of the glucocorticoid circadian clock: from the ontogeny to the diagnosis of Cushing’s syndrome

Moreira

Antonini

Castro

2018

European Journal of Endocrinology

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The circadian rhythm of glucocorticoids has long been recognised within the last 75 years. Since the beginning, researchers have sought to identify basic mechanisms underlying the origin and emergence of the corticosteroid circadian rhythmicity among mammals. Accordingly, Young, Hall and Rosbash, laureates of the 2017 Nobel Prize in Physiology or Medicine, as well as Takahashi's group among others, have characterised the molecular cogwheels of the circadian system, describing interlocking transcription/translation feedback loops essential for normal circadian rhythms. Plasma glucocorticoid circadian variation depends on the expression of intrinsic clock genes within the anatomic components of the hypothalamic-pituitary-adrenal axis, which are organised in a hierarchical manner. This review presents a general overview of the glucocorticoid circadian clock mechanisms, highlighting the ontogeny of the pituitary-adrenal axis diurnal rhythmicity as well as the involvement of circadian rhythm abnormalities in the physiopathology and diagnosis of Cushing's disease.

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“…Numerous biochemical tests have been proposed for the diagnosis of hypercortisolism; however, their diagnostic accuracy depends upon etiology of hypercortisolism, patient's comorbidities, robustness of the assays, concomitant medications and the setting of investigations [39].…”

Section: Advances In Diagnostic Testing and Need For New Testsmentioning

confidence: 99%

“The Adrenal Gland: Central Relay in Health and Disease - Current Challenges and Perspectives 2018” – Cushing’s Disease

Stalla

Ciato

Dimopoulou

2018

Exp Clin Endocrinol Diabetes

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CD is associated to a significant clinical burden, since numerous comorbidities persist after long-term biochemical control. These chronically ill patients show an increased mortality despite disease remission. Clinicians should treat comorbidities aggressively and seek for appropriate consultations. Structured consultation hours and expert excellence networks are needed in order to allow optimal, individualized care for affected patients, reverse increased morbidity and mortality and identify tumor recurrence early.

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Diagnostic tests for Cushing's syndrome differ from published guidelines: data from ERCUSYN

Cited by 57 publications

References 49 publications

Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN

Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN

MECHANISMS IN ENDOCRINOLOGY: A sense of time of the glucocorticoid circadian clock: from the ontogeny to the diagnosis of Cushing’s syndrome

“The Adrenal Gland: Central Relay in Health and Disease - Current Challenges and Perspectives 2018” – Cushing’s Disease

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