Diagnostic Techniques: Angiography

Günduz, Kaan; Yeşiltaş, Yağmur Seda

doi:10.1007/978-3-030-04489-3_19

Cited by 1 publication

(1 citation statement)

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“…Despite being able to distinguish lesions from normal tissue, the low penetration capability of OCT limits its usage to only very thin lesions, typically less than 1 mm in thickness, especially in melanocytic lesions [ 11 ], whereas choroidal tumors can have a height of up to 10 mm [ 12 ]. Imaging techniques such as fluorescein angiography (FA), indocyanine green angiography (ICGA), and fundus autofluorescence (FAF) can provide valuable information such as changes in the retinal pigmented epithelium (RPE) overlying ocular lesions, tumor vasculature, and associated vascular leakage [ 1 , 2 , 13 , 14 ]. However, these imaging modalities do not provide sufficient information related to tumor depth, and their standalone diagnostic accuracy is relatively low.…”

Section: Introductionmentioning

confidence: 99%

Integrating a Fundus Camera with High-Frequency Ultrasound for Precise Ocular Lesion Assessment

Rossi,

Zeng,

Rahimi

et al. 2024

Biosensors

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Ultrasound A-scan is an important tool for quantitative assessment of ocular lesions. However, its usability is limited by the difficulty of accurately localizing the ultrasound probe to a lesion of interest. In this study, a transparent LiNbO3 single crystal ultrasound transducer was fabricated, and integrated with a widefield fundus camera to guide the ultrasound local position. The electrical impedance, phase spectrum, pulse-echo performance, and optical transmission spectrum of the ultrasound transducer were validated. The novel fundus camera-guided ultrasound probe was tested for in vivo measurement of rat eyes. Anterior and posterior segments of the rat eye could be unambiguously differentiated with the fundus photography-guided ultrasound measurement. A model eye was also used to verify the imaging performance of the prototype device in the human eye. The prototype shows the potential of being used in the clinic to accurately measure the thickness and echogenicity of ocular lesions in vivo.

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