Diagnostic stewardship: what impacts antibiotics use?

Abstract

Purpose of review The aim of this study was to review recently published diagnostic stewardship studies of common clinical infectious syndromes and the impact on antibiotic prescribing. Recent findings Diagnostic stewardship can be implemented within healthcare systems and tailored to infectious syndromes, including urinary tract, gastrointestinal, respiratory and bloodstream infections. In urinary syndromes, diagnostic stewardship can decrease unnecessary urine culturing and associated antibiotic prescribing. Diagnostic stewardship of Clostridium difficile testing can decrease antibiotics and test ordering with a reduction in healthcare-associated C. difficile infections. Respiratory syndrome multiplex arrays can decrease time to results and increase detection of clinically relevant pathogens but may not decrease antibiotics use, or worse, could increase over-prescribing if diagnostic stewardship of ordering practices is not exercised. Lastly, blood culturing practices can be improved by clinical decision support to safely decrease collection and broad-spectrum antibiotic use. Summary Diagnostic stewardship decreases unnecessary antibiotic use in a way that is different from and complementary to antibiotic stewardship. Further studies are needed to quantify the full impact on antibiotic use and resistance. Future considerations should be to institutionalize diagnostic stewardship in patient care activities to leverage integration into systems-based interventions.

Problematik Infeksi Clostridium difficile

“…A multidisciplinary antibiotic management program to limit inappropriate antibiotic use could lead to a significant reduction in nosocomial infections caused by C. difficile. 39,40 The first steps in treating patients with CDI include discontinuing the offending agent such as antimicrobials, if possible, and providing appropriate supportive care with hydration and electrolyte replacement as needed. Anti-diarrhea medications should be avoided as they can obscure symptoms and trigger toxic megacolon.…”