Diagnostic Significance of Serum Neuron-Specific Enolase and Myelin Basic Protein Assay in Patients with Acute Head Injury

The Prognostic Value of Neuron-Specific Enolase in Head Trauma Patients

“…A total of 18 (45%) patients from these two groups died. This finding is compatible with those of previous studies (1,12). Vos et al reported high posttrauma NSE and S-100B protein values in severe head trauma patients.…”

Biomarkers Improve Clinical Outcome Predictors of Mortality Following Non-Penetrating Severe Traumatic Brain Injury

“…Although there are a number of biochemical markers that have been investigated in TBI, the most extensively studied among these are glial protein S-100 beta (b) [6][7][8][9][10][11][12][13][14][15][16], neuron-specific enolase (NSE) [17][18][19][20][21][22], and myelin basic protein (MBP) [20,[23][24][25][26] S100b is the major low affinity calcium binding protein in astrocytes [41] and it is considered a marker of astrocyte injury or death. Alpha-IIspectrin (280 kDa) is the major structural component of the cortical membrane cytoskeleton and is particularly abundant in axons and presynaptic terminals [42,43].…”

“…Together with clinical assessment, the quantitative evaluation of neuronal biomarkers measured within 24 h from either cerebrospinal fluid (CSF) and/or blood could assist in the determination of injury severity, provide specifics to anatomical and cellular pathology of the injury, and could alter clinical management. Although there are a number of biochemical markers that have been investigated in TBI, the most extensively studied among these are glial protein S-100 beta (b) [6][7][8][9][10][11][12][13][14][15][16], neuron-specific enolase (NSE) [17][18][19][20][21][22], and myelin basic protein (MBP) [20,[23][24][25][26] Other promising biomarkers include alpha-II-spectrin breakdown products [27][28][29][30], Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) [31][32][33][34], and microtubule-associated protein (MAP-2) [35].…”

Reliability of S100B in predicting severity of central nervous system injury

“…NSE is a cytoplasmic glycolytic enzyme of neurons [136][137][138][139]. NSE and S100B serum levels in trauma patients have been found to correlate well to each other and to clinical outcomes and neuroimaging findings of contusion volume and presence of subarachnoid hemorrhage [70,112,121].…”