Diagnostic significance of microRNAs as novel biomarkers for bladder cancer: a meta-analysis of ten articles

Abstract

BackgroundPrevious studies have revealed the importance of microRNAs’ (miRNAs) function as biomarkers in diagnosing human bladder cancer (BC). However, the results are discordant. Consequently, the possibility of miRNAs to be BC biomarkers was summarized in this meta-analysis.MethodsIn this study, the relevant articles were systematically searched from CBM, PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI). The bivariate model was used to calculate the pooled diagnostic parameters and summary receiver operator characteristic (SROC) curve in this meta-analysis, thereby estimating the whole predictive performance. STATA software was used during the whole analysis.ResultsThirty-one studies from 10 articles, including 1556 cases and 1347 controls, were explored in this meta-analysis. In short, the pooled sensitivity, area under the SROC curve, specificity, positive likelihood ratio, diagnostic odds ratio, and negative likelihood ratio were 0.72 (95%CI 0.66–0.76), 0.80 (0.77–0.84), 0.76 (0.71–0.81), 3.0 (2.4–3.8), 8 (5.0–12.0), and 0.37 (0.30–0.46) respectively. Additionally, sub-group and meta-regression analyses revealed that there were significant differences between ethnicity, miRNA profiling, and specimen sub-groups. These results suggested that Asian population-based studies, multiple-miRNA profiling, and blood-based assays might yield a higher diagnostic accuracy than their counterparts.ConclusionsThis meta-analysis demonstrated that miRNAs, particularly multiple miRNAs in the blood, might be novel, useful biomarkers with relatively high sensitivity and specificity and can be used for the diagnosis of BC. However, further prospective studies with more samples should be performed for further validation.

Serum and tissue miRNAs: potential biomarkers for the diagnosis of cervical cancer

“…These features render miRNAs to be considered as prognostic biomarkers of cancers, which differentiate the normal from tumour tissues [39]. The high sensitivity and specificity and the possibility of the non-invasive collection of miRNAs led to the interest in examining miRNAs as biomarkers [40]. For this purpose, the miR-9, miR-192 and miR-205 levels were investigated in cervical samples.…”

Prognostic and clinicopathological importance of microRNA-140 expression in cancer patients: a meta-analysis

“…In addition to taking effective measures to improve the effects of aging and growth of the population and unequal socioeconomic development, researchers have carried out a large number of small and more in-depth studies to explore and mitigate the cancer burden [ 2 ]. To date, cancer-related lncRNAs, miRNAs, RNAs, and proteins have been continuously discovered to be related to prognosis after surgery [ 3 – 5 ]. However, paradoxical results have always appeared in previous studies; therefore, we conducted this analysis to find a stable prognostic marker that could potentially reduce the future cancer burden.…”

MicroRNA‑503‑5p improves carotid artery stenosis by inhibiting the proliferation of vascular smooth muscle cells

“…In recent years, due to its high sensitivity, specificity and non-invasive nature, the detection of miRNAs as biomarkers has attracted an increasing amount of attention ( 22 ). In human cancer, certain serum miRNAs may be used as diagnostic and prognostic markers, including miR-1290( 23 ), miR-141( 24 ) and miR-193b ( 25 ).…”

“…In recent years, due to its high sensitivity, specificity and non-invasive nature, the detection of miRNAs as biomarkers has attracted an increasing amount of attention (22). In human Table I.…”