Diagnostic significance of basal TSH-concentrations (TSH-IRMA)

Passath, A; G, Leb; Warnkrolβ, H.

doi:10.1515/9783110867398-031

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the present paper shows that there is no need to carry out a TRH-test in euthyroid depressed patients. These conclusions concur with the recent findings in endocrinology which have revealed that in 96-100% of cases, basal TSH determined by sensitive IRMAtechniques is a reliable predictor of the TSH response to TRH (Bretzel et al, 1987;Passath et al, 1987;Pfannenstiel et al, 1987). Therefore, the authors fee1 that the approach to the thyroid-function testing strategy in depressed patients should re1y on determinations of basal TSH-IRMA.…”

Section: Utility Oftrh-testingsupporting

confidence: 91%

“…Therefore, the authors fee1 that the approach to the thyroid-function testing strategy in depressed patients should re1y on determinations of basal TSH-IRMA. Only when basal TSH-IRMA levels are blunted «0.I5I1UI/rnl) or increased (> 5.0 I1UI/rnl) are follow-up tests advisable (determination of thyroid hormones) in order to exclude hypo-or hyperthyroid illness (Bretzel et al, 1987;Passath et al, 1987;P/annenstiel et al, 1987).…”

Section: Utility Oftrh-testingmentioning

confidence: 99%

See 1 more Smart Citation

TSH Responses to TRH as a Function of Basal Serum TSH: Relevance for Unipolar Depression in Females - A Multivariate Study

Maes¹,

Schotte²,

Vandewoude³

et al. 1992

Pharmacopsychiatry

View full text Add to dashboard Cite

Baseline thyroid-secreting-hormone (TSH)-assessed by means of ultrasensitive assays (IRMA)-and free-thyroid-hormone (FT4) levels were determined in 84 depressed females, and the TSH responses to 200 micrograms thyrotropin-releasing hormone (TRH) (IV) measured. It was found that TRH-induced TSH responses were linearly and positively related to basal TSH-IRMA; lower TRH-stimulated TSH secretion in melancholic patients was attributable to lowered basal TSH-IRMA values. A progression was found-within the euthyroid range-of basal TSH-IRMA values towards lower levels along the diagnostic spectrum: the highest basal TSH-IRMA levels were witnessed in minor depressives and the lowest in melancholics, while simple major-depressed females occupied an intermediate position. This shift appears to be indicative of severity of illness. Basal TSH-IRMA data can roughly be used as a clinical tool separating melancholia from minor depression: at a threshold value of less than or equal to 1 microUI/ml, sensitivity was 56% and specificity 92%. It is concluded that basal TSH-IRMA provides a more accurate representation of melancholia than peak TSH responses, which appear to constitute little more than a magnified, but biased signal of basal TSH-IRMA. In future, the assay of basal TSH-IRMA could replace TRH testing.

show abstract

Section: Utility Oftrh-testingsupporting

confidence: 91%

Section: Utility Oftrh-testingmentioning

confidence: 99%