Diagnostic role of BAL fluid CD4/CD8 ratio in different radiographic and clinical forms of pulmonary sarcoidosis

Danila, Edvardas; Norkūnienė, Jolita; Jurgauskienė, Laimutė; Malickaitė, Radvilė

doi:10.1111/j.1752-699x.2008.00126.x

Cited by 46 publications

(39 citation statements)

References 37 publications

(49 reference statements)

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“…They also found that optimal cut-off points for CD4/CD8 ratio are 3.5 and 4.0 for asymptomatic and symptomatic patients, respectively. 66 In the present study, TBLB was performed in 36.6% of the patients (i.e. 11/30) and more than half of them were diagnostic (i.e.8/11).…”

Section: Resultsmentioning

confidence: 99%

Sarcoidosis- A Clinicoradiological Profile of 30 Patients

Kumar¹,

Kumar²,

Kumar³

et al. 2017

jemds

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Section: Resultsmentioning

confidence: 99%

Sarcoidosis- A Clinicoradiological Profile of 30 Patients

Kumar¹,

Kumar²,

Kumar³

et al. 2017

jemds

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“…However, cellular components of BALF and T lymphocyte profiles are associated with several situations, such as clinical presentation, radiological stage and smoking status (17,18). A high relative CD4 + T lymphocyte number (percentage) and high CD4/CD8 ratio, increased alveolar macrophages amount in BALF reflect an active inflammatory process in the lung.…”

Section: Discussionmentioning

confidence: 99%

“…BALF analysis was performed as described in previous publications (17,18). We used the same BAL and BALF methods of analysis throughout the study period.…”

Section: Bronchoscopy and Bronchoalveolar Lavagementioning

confidence: 99%

“…Fiberoptic bronchoscopy and bronchoalveolar lavage were performed as described elsewhere (18,29,30). BALF analysis was performed as described in previous publications (17,18).…”

Section: Bronchoscopy and Bronchoalveolar Lavagementioning

confidence: 99%

“…Recently, the correlation between disease severity in CT, functional impairment and radiographic stages of sarcoidosis, as well as pulmonary function tests (PFT) and bronchoalveolar lavage fluid (BALF) cells, have been discussed in the literature (5,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). However, few systematic evaluations exist exploring the relationships between the various HRCT findings (e.g., micronodules, macronodules, irregular linear opacities, interlobular septal thickening, fibrotic changes, etc.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

Aleksonienė¹,

Zeleckienė²,

Matačiūnas³

et al. 2017

J. Thorac. Dis.

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Background: The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead to optimize of the patient follow-up frequency. Methods: Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed tomography (HRCT) examination, pulmonary function tests (PFT), bronchoscopy with bronchoalveolar lavage (BAL) and lung biopsy, and bronchoalveolar lavage fluid (BALF) cell examination. Results: The reduction in PFT values seen in radiological sarcoidosis stage III was greater than that seen in stages I and II. The percentage of neutrophils in the lungs was found to increase in stages II and III. PFT indices were correlated negatively with the consolidation and ground glass opacities CT scores, but not with the micronodule or macronodule scores. The rise in the percentage of BALF lymphocytes was associated with the restriction pattern of PFT. The diagnostic value of BALF for sarcoidosis was higher when the typical radiologic patterns of stage I disease were found and that smoking decreased the diagnostic value of CD4/CD8 ratio. Conclusions: This study supports the opinion that the staging of the pulmonary sarcoidosis with chest X-rays is still valuable from the prognostic point of view, because significant correlations between the radiologic stages of sarcoidosis and PFT parameters were found. Chest HRCT was significantly superior to chest X-ray in detecting mediastinal and pulmonary parenchymal changes. However, the prognostic role of HRCT needs to be better investigated evaluating serial examinations. Only consolidation and ground glass scores (neither of which are frequently found in sarcoidosis) hold prognostic value, since these were negatively correlated with PFT parameters.

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Report of the results of the International Clinical Cytometry Society and American Society for Clinical Pathology workload survey of clinical flow cytometry laboratories

Wolniak

Goolsby

Choi

et al. 2016

Cytometry Part B Clinical

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Diagnostic role of BAL fluid CD4/CD8 ratio in different radiographic and clinical forms of pulmonary sarcoidosis

Abstract: BAL is a valuable method in diagnostic pathway of pulmonary sarcoidosis. However, results of BALF examination must be interpreted considering a specific clinical case. BALF CD4/CD8 ratio depends on clinical and radiographic manifestation.

Cited by 46 publications

References 37 publications

Sarcoidosis- A Clinicoradiological Profile of 30 Patients

Sarcoidosis- A Clinicoradiological Profile of 30 Patients

Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis

Report of the results of the International Clinical Cytometry Society and American Society for Clinical Pathology workload survey of clinical flow cytometry laboratories

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