Diagnostic role of 18F-dihydroxyphenylalanine positron emission tomography in patients with congenital hyperinsulinism

Yang, Jigang; Hao, Ruirui; Zhu, Xiaohua

doi:10.1097/mnm.0b013e32835e6ac6

Cited by 22 publications

(21 citation statements)

References 22 publications

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“…An I 2 statistic was also analyzed to test for heterogeneity between studies [15]. The statistical analysis of this meta-analysis referred to a previous meta-analysis [16][17][18][19]. Statistical analyses were performed using Meta-DiSc statistical software, version 1.4 (Unit of Clinical Biostatistics, Ramony Cajal Hospital, Madrid, Spain) [20].…”

Section: Discussionmentioning

confidence: 99%

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

Xiao

Chen²,

Shi³

et al. 2015

Nuclear Medicine Communications

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Section: Discussionmentioning

confidence: 99%

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

Xiao

Chen²,

Shi³

et al. 2015

Nuclear Medicine Communications

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“…Following the initial description of its role in identifying the focal lesion38), its usefulness has been reported in a number of publications39,40). 18 F-DOPA PET detects focal lesions as small as 5 mm and is better preformed as PET-CT.…”

Section: Known Etiologies Of Chi (Table 2)mentioning

confidence: 99%

Congenital hyperinsulinism: current status and future perspectives

Yorifuji

2014

Ann Pediatr Endocrinol Metab

147

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The diagnosis and treatment of congenital hyperinsulinism (CHI) have made a remarkable progress over the past 20 years and, currently, it is relatively rare to see patients who are left with severe psychomotor delay. The improvement was made possible by the recent developments in the understanding of the molecular and pathological basis of CHI. Known etiologies include inactivating mutations of the KATP channel genes (ABCC8 and KCNJ11) and HNF4A, HNF1A, HADH, and UCP2 or activating mutations of GLUD1, GCK, and SLC16A1. The understanding of the focal form of KATP channel CHI and its detection by 18F-fluoro-L-DOPA positron emission tomography have revolutionized the management of CHI, and many patients can be cured without postoperative diabetes mellitus. The incidence of the focal form appears to be higher in Asian countries; therefore, the establishment of treatment systems is even more important in this population. In addition to diazoxide or long-term subcutaneous infusion of octreotide or glucagon, long-acting octreotide or lanreotide have also been used successfully until spontaneous remission. Because of these medications, near-total pancreatectomy is less often performed even for the diazoxide-unresponsive diffuse form of CHI. Other promising medications include pasireotide, small-molecule correctors such as sulfonylurea or carbamazepine, GLP1 receptor antagonists, or mammalian target of rapamycin inhibitors. Unsolved questions in this field include the identification of the remaining genes responsible for CHI, the mechanisms leading to transient CHI, and the mechanisms responsible for the spontaneous remission of CHI. This article reviews recent developments and hypothesis regarding these questions.

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“…In diffuse CHI there is generalised increased tracer uptake with a relatively higher uptake in the head when compared to the rest of the pancreas [14,26,27] . 18 F-DOPA is excreted by kidneys hence normal bio-distribution is seen in kidneys, ureter and urinary bladder.…”

Section: +mentioning

confidence: 99%

“…The area under the summary receiver operating characteristic curve (SROC) was estimated to be 0.92% suggesting that 18 F-DOPA PET and PET/CT imaging are accurate tools for distinguishing focal diagnosing CHI, although there is a minimal risk of both false positive and false negative results. The authors concluded that 18 F-DOPA PET is very helpful in differentiating between focal and diffuse lesions, and should be the first investigation of choice when the genetic test results are inconclusive and 18 F-DOPA PET/CT is very helpful in localising the lesion and thereby improving the treatment outcome in focal CHI [27] . Blomberg et al [38] conducted a systematic review and meta-analysis recently to quantify the diagnostic performance of pancreatic venous sampling (PVS), selective pancreatic arterial calcium stimulation with hepatic venous sampling (ASVS) and 18 F-DOPA-PET/CT in diagnosing and localising focal CH.…”

Section: F-dopa-pet/ct In Chimentioning

confidence: 99%

Congenital hyperinsulinism: Role of fluorine-18L-3, 4 hydroxyphenylalanine positron emission tomography scanning

Gopal‐Kothandapani

Hussain

2014

WJR

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Congenital hyperinsulinism (CHI) is a rare but complex heterogeneous disorder caused by unregulated secretion of insulin from the β-cells of the pancreas leading to severe hypoglycaemia and neuroglycopaenia. Swift diagnosis and institution of appropriate management is crucial to prevent or minimise adverse neurodevelopmental outcome in children with CHI. Histologically there are two major subtypes of CHI, diffuse and focal disease and the management approach will significantly differ depending on the type of the lesion. Patients with medically unresponsive diffuse disease require a near total pancreatectomy, which then leads on to the development of iatrogenic diabetes mellitus and pancreatic exocrine insufficiency. However patients with focal disease only require a limited pancreatectomy to remove only the focal lesion thus providing complete cure to the patient. Hence the preoperative differentiation of the histological subtypes of CHI becomes paramount in the management of CHI. Fluorine-18L-3, 4-hydroxyphenylalanine positron emission tomography ( 18 F-DOPA-PET) is now the gold standard for pre-operative differentiation of focal from diffuse disease and localisation of the focal lesion. The aim of this review article is to give a clinical overview of CHI, then review the role of dopamine in β-cell physiology and finally discuss the role of

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Diagnostic role of 18F-dihydroxyphenylalanine positron emission tomography in patients with congenital hyperinsulinism

Abstract: In patients with CHI, F-DOPA PET or PET/CT demonstrated high sensitivity and specificity. F-DOPA PET and PET/CT are accurate methods for the diagnosis of CHI. Nevertheless, possible sources of false-positive and false-negative results should be kept in mind.

Cited by 22 publications

References 22 publications

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

The value of fluorine-18 fluorodeoxyglucose PET/MRI in the diagnosis of head and neck carcinoma

Congenital hyperinsulinism: current status and future perspectives

Congenital hyperinsulinism: Role of fluorine-18L-3, 4 hydroxyphenylalanine positron emission tomography scanning

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