Diagnostic reliability of endomyocardial biopsy for assessment of cardiac allograft rejection

Zerbe, Tony R.; Arena, Vincent C.

doi:10.1016/s0046-8177(88)80286-7

Cited by 78 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were only a few areas in the sub-endocardium where a biopsy of the site might have demonstrated Grade 1A rejection. This is contrary to the findings of Zerbe et al, 18 who noted that "rejection is evenly distributed throughout the right ventricular endomyocardium." Rather, we saw a gradient: the infiltrates were minimal in the endocardium, more severe in the myocardium, and intense in the epicardium and pericardial tissue.…”

Section: Discussioncontrasting

confidence: 92%

Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy

Bhalodolia

Cortese

Graham

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 92%

Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy

Bhalodolia

Cortese

Graham

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…The subendomyocardial layer was free from rejection. This is contrary to other studies which have found that rejection is evenly distributed throughout the right ventricular endomyocardium [6]. Although endomyocardial biopsy is the primary resource to diagnose acute rejections in all the cases discussed in this study, there are a few noninvasive diagnostics that have been demonstrated to be helpful in diagnosing acute allograft rejection after heart transplantation.…”

Section: Discussioncontrasting

confidence: 81%

683 The Natural History of Biopsy Negative Rejection after Heart Transplantation

Patel¹,

Kittleson²,

Rafiei³

et al. 2012

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

.Purpose. The most recent International Society for Heart and Lung Transplantation (ISHLT) biopsy scale classifies cellular and antibody-mediated rejections. However, there are cases with acute decline in left ventricular ejection fraction (LVEF ≤ 45%) but no evidence of rejection on biopsy. Characteristics and treatment response of this biopsy negative rejection (BNR) have yet to be elucidated. Methods. Between 2002 and 2012, we found 12 cases of BNR in 11 heart transplant patients as previously defined. One of the 11 patients was treated a second time for BNR. Characteristics and response to treatment were noted. Results. 12 cases (of 11 patients) were reviewed and 11 occurred during the first year after transplant. 8 cases without heart failure symptoms were treated with an oral corticosteroids bolus and taper or intravenous immunoglobulin. Four cases with heart failure symptoms were treated with thymoglobulin, intravenous immunoglobulin, and intravenous methylprednisolone followed by an oral corticosteroids bolus and taper. Overall, 7 cases resulted in return to normal left ventricular function within a mean of 14 ± 10 days from the initial biopsy. Conclusion. BNR includes cardiac dysfunction and can be a severe form of rejection. Characteristics of these cases of rejection are described with most cases responding to appropriate therapy.

show abstract

“…[19][20][21] In cardiac allografts, Zerbe and Arena 21 demonstrated that the level of sensitivity improves with an increasing number of endomyocardial biopsy samples but that sensitivity does not improve when more than six pieces are examined. In our study we found a very high degree of correlation between EmBx and RV and LV cross sections, particularly for irreversible characteristics of DXR such as coagulative necrosis and thrombosis.…”

Section: Discussionmentioning

confidence: 99%

The Utility of Right Ventricular Endomyocardial Biopsy for the Diagnosis of Xenograft Rejection After CD46 Pig-to-Baboon Cardiac Transplantation

Ricci

Tazelaar

Miyagi

et al. 2007

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Introduction-Endomyocardial biopsy (EmBx) is the standard means of establishing cardiac allograft rejection diagnosis. The efficacy of this procedure in xenotransplantation has not been determined. In this study we compare the histology of right ventricular EmBx specimens with the corresponding full cross sections of explanted right ventricle (RV). We also compare RV with the related left ventricle (LV) cross sections.

show abstract

Diagnostic reliability of endomyocardial biopsy for assessment of cardiac allograft rejection

Cited by 78 publications

References 8 publications

Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy

Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy

683 The Natural History of Biopsy Negative Rejection after Heart Transplantation

The Utility of Right Ventricular Endomyocardial Biopsy for the Diagnosis of Xenograft Rejection After CD46 Pig-to-Baboon Cardiac Transplantation

Contact Info

Product

Resources

About