Diagnostic quality of percutaneous fine-needle aspirates and laparoscopic biopsy specimens of the liver in rabbits (Oryctolagus cuniculus)

Proença, Laila M.; Camus, Melinda S.; Nemeth, Nicole M.; Sharma, Ajay; Stelmach, Dainna; Mayer, Jörg; Divers, Stephen J.

doi:10.2460/javma.246.3.313

Cited by 5 publications

(1 citation statement)

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“…Overall, these findings suggest that, regardless of the gross appearance, a liver biopsy is the recommended course of action if liver disease is a potential differential. Furthermore, endoscopic liver biopsies are safe and provide sufficient samples for histopathology in green iguanas ( Iguana iguana ), dogs ( Canis lupus familiaris ), rabbits ( Oryctolagus cuniculus ) and human beings 24–26 …”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of plasma biochemistry, haematology, radiography and endoscopic visualisation for hepatic disease in psittacine birds

2020

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BackgroundHepatic disease in psittacine birds is common but challenging to diagnose. This retrospective study evaluates the diagnostic value of plasma biochemistry, haematology, radiography and endoscopic visualisation in psittaciforms with suspected hepatic disease that underwent endoscopic liver biopsy.MethodsClinical records of 28 companion psittaciforms from a veterinary teaching hospital (2007–2016) were reviewed. Diagnostic results were categorised as abnormal or normal and compared with histopathology for agreement or disagreement. Statistical significance was determined by kappa test for agreement and McNemar’s test for disagreement.Results11 of 28 psittaciforms (39.3 per cent) had clinical signs considered specific for liver disease. 25 of 28 (89.3 per cent) psittaciforms had histopathological liver lesions. Gross changes radiographically and endoscopically agreed with histopathology in 57.1 per cent and 53.6 per cent of cases, respectively. Aspartate aminotransferase (AST) (48.1 per cent), creatine phosphokinase (73.1 per cent) and albumin by protein electrophoresis (50 per cent) showed the highest agreement. Kappa was not significant for any parameters, while McNemar’s test for disagreement was significant for radiography, endoscopy, AST, lactate dehydrogenase, bile acid, total protein (chemistry), cholesterol, triglycerides, uric acid and glucose.ConclusionOverall, changes on plasma biochemistry, radiography or endoscopy are non-specific and do not consistently agree with histopathology results. Endoscopic liver biopsy is highly recommended if there is clinical suspicion of hepatic disease.

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Section: Discussionmentioning

confidence: 99%