Diagnostic protein marker patterns in squamous cervical cancer

Lomnytska, Marta; Becker, Susanne; Hellman, Kristina; Hellström, Ann‐Cathrin; Souchelnytskyi, Serhiy; Mints, Miriam; Hellman, Ulf; Andersson, Sonia; Auer, Gert

doi:10.1002/prca.200900086

Cited by 49 publications

(59 citation statements)

References 39 publications

(51 reference statements)

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“…Of all the cervical malignancies, 70-80% are squamous cell cervical carcinoma (SCC) originating from squamous cell epithelia (SCEs) (25).…”

Section: Roles Of Anxa6 In Cervical Cancer Progression and Malignancymentioning

confidence: 99%

“…A number of studies have demonstrated that AnxA6 is associated with the progression and malignancy of CC, and it is a potential protein marker for SCC development (25,40). Proteomic results of Lomnytska et al (25) demonstrated that AnxA6 was overexpressed in SCC, and the N-terminus of AnxA6 was upregulated 2-fold in SCC compared with cervical mucosa (CM).…”

Section: Roles Of Anxa6 In Cervical Cancer Progression and Malignancymentioning

confidence: 99%

“…Proteomic results of Lomnytska et al (25) demonstrated that AnxA6 was overexpressed in SCC, and the N-terminus of AnxA6 was upregulated 2-fold in SCC compared with cervical mucosa (CM). In addition, strong expression of AnxA6 was observed in the nucleus of SCC cells, compared with the weak or moderate expression observed in the cytoplasm of SCE cells (25). However, these may be infiltrating immune cells, since their histopathological appearance was observed to be variable (40).…”

Section: Roles Of Anxa6 In Cervical Cancer Progression and Malignancymentioning

confidence: 99%

“…It has been implicated as a potential marker for cervical cancer (CC) (25), and as a tumor suppressor in melanoma (26), epithelial carcinoma (23,(27)(28)(29), breast cancer (BC) (23,28), gastric cancer (GC) (30), prostate cancer (PCa) (31,32) and chronic myeloid leukemia (CML) (33). Furthermore, AnxA6 is considered to act as a promoting factor in the cellular adhesion, motility and invasiveness of BC (34,35), the progression of acute lymphoblastic leukemia (ALL) (36), the adhesion of lymphoma (37), and the secretory processes in myeloma cells (21).…”

Section: Introductionmentioning

confidence: 99%

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Role of annexin A6 in cancer

Liu

Guo

et al. 2015

Oncology Letters

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Abstract. Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca 2+ -dependent membrane-binding annexin proteins. It participates in membrane and cytoskeleton organization, cholesterol homeostasis, membrane trafficking, cell adhesion and signal transduction. The expression levels of AnxA6 are closely associated with melanoma, cervical cancer, epithelial carcinoma, breast cancer, gastric cancer, prostate cancer, acute lymphoblastic leukemia, chronic myeloid leukemia, large-cell lymphoma and myeloma. AnxA6 exhibits dual functions in cancer, acting either as a tumor suppressor or promoter, depending on the type of cancer and the degree of malignancy. In several types of cancer, AnxA6 acts via Ras, Ras/MAPK and/or FAK/PI3K signaling pathways by mainly mediating PKCα, p120GAP, Bcr-Abl and YY1. In the present review, the roles of AnxA6 in different types of cancer are summarized.

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“…Of all the cervical malignancies, 70-80% are squamous cell cervical carcinoma (SCC) originating from squamous cell epithelia (SCEs) (25).…”

Section: Roles Of Anxa6 In Cervical Cancer Progression and Malignancymentioning

confidence: 99%

Section: Roles Of Anxa6 In Cervical Cancer Progression and Malignancymentioning

confidence: 99%

Section: Roles Of Anxa6 In Cervical Cancer Progression and Malignancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of annexin A6 in cancer

Liu

Guo

et al. 2015

Oncology Letters

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“…Cathepsin D is an aspartic acid protease which has been studied as a potential biomarker with increased expression in colorectal cancer, while its high levels have been linked to metastatic events (45). Furthermore, it has been reported to be highly secreted from lung cancer cell lines (46) and up-regulated in vaginal cancer compared to cervical cancer (47), playing also a role as a biomarker in breast cancer (48). Pro-cathepsin D has been found to be secreted from cancer cells and bound either by stromal cells inducing the proliferation of fibroblasts and further promoting carcinogenesis or by endothelial cells, and promoting angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases

Pappa

Kontostathi

Makridakis

et al. 2017

CGP

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Abstract. Background: Oncogenic infection by HPVThe vast majority of cervical cancer incidents are related to a group of 13 high-risk oncogenic human papilloma virus (HPV) types, classified according to sequence similarity, based on established criteria by the International Committee on the Taxonomy of Viruses (1). Types HPV16 and HPV18 represent the most common high-risk types causing cervical cancer (2, 3). Microabrasions on the cervical epithelium surface, allow the entry of HPV and the ensuing infection of the basal membrane epithelium. The initial overexpression of E6 and E7 HPV oncoproteins in the upper layers of the epithelium, leads to the production of viral particles and the establishment of productive infection, associated with the formation of low-grade squamous intraepithelial lesions (LSIL). Subsequent integration of the virus in the host cells, results in progression to high-grade squamous intraepithelial lesions (HSIL), leading eventually to cervical cancer (4-7).Proteomics technologies offer an holistic approach through the identification of many critical proteins, that could facilitate the understanding of biological mechanisms underlying cervical cancer pathogenesis. Proteomic tools have been utilized to study the mechanisms of action of drugs and the discovery of putative biomarkers for cervical cancer (8). However, in the above approaches, only the two-dimensional gel electrophoresis (2DE) coupled to MALDI-TOF has been utilized in most studies so far, whereas the LC-MS/MS technology, a very sensitive technology, has not been widely used. Furthermore, in these few studies where LC-MS/MS was applied, only the intracellular proteome was analyzed, 507

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ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction

Sun

Shu

et al. 2020

Clinical & Translational Med

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Autophagy is an intracellular degradation pathway conserved in eukaryotes. ANXA6 (annexin A6) belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Here, we identify ANXA6 as a newly synthesized protein in starvation-induced autophagy and validate it as a novel autophagy modulator that regulates autophagosome formation. ANXA6 knockdown attenuates starvation-induced autophagy and restoration of its expression enhances autophagy. GO (gene ontology) analysis of ANXA6 targets showed that ANXA6 interacts with many RAB GTPases and targets endocytic and phagocytosis pathways, indicating that ANXA6 exert its function through protein trafficking. ATG9A (autophagy related 9A) is the sole multi-spanning transmembrane protein and its trafficking through the recycling endosomes is an essential step for autophagosome formation. Our results showed that under starvation condition, ANXA6 enables appropriate ATG9A trafficking from endosomes to autophagosomes through RAB proteins or F-actin. In addition, restoration of ANXA6 expression suppresses mTOR (mammalian target of rapamycin) activity through the inhibition of the PI3K (phosphoinositide 3-kinase)-AKT and the ERK (extracellular signal-regulated kinase) signaling pathway, which is a

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Diagnostic protein marker patterns in squamous cervical cancer

Abstract: SCC is characterized by specific tissue marker protein patterns that allow objective detection of the disease. They can become a basis for objective automated cytology-based screening and improve current diagnostics of SCC.

Cited by 49 publications

References 39 publications

Role of annexin A6 in cancer

Role of annexin A6 in cancer

High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases

ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction

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