Diagnostic Problems and Advances in Inflammatory Bowel Disease

A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis

“…As with tumors found in human IBD, 23 most of the lesions in Stat3-IKO mice were "flat" with a broad base ( Figure 2C) or morphologically similar to "dysplasia-associated lesions or masses." 24 Carcinoma was identified in some of these nodules, with tumor invasion to submucosa or even muscularis external ( Figure 2D, arrow).…”

Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features

“…1,2 Ulcerative colitis nearly always involves the rectum before treatment, is diffuse and continuous, and typically shows an absence of Crohn's disease-like histological features, such as granulomas, deep fissuring ulcers, transmural lymphoid aggregates, and small intestine involvement. 3,4 Recent studies have suggested that some cases of ulcerative colitis may show Crohn's disease-like features, such as patchy and segmental disease, early fissuring ulcers (particularly in fulminant cases), granulomas related to ruptured crypts, right-sided appendiceal/cecal involvement in patients with left-sided disease, and small intestine involvement. 3,[5][6][7][8][9][10] The pathological spectrum, and outcome, of patients with both typical and atypical ulcerative colitis has been well investigated.…”

Patchy colitis, and young age at diagnosis and at the time of surgery predict subsequent development of Crohn's disease after ileal pouch‐anal anastomosis surgery for ulcerative colitis

“…Following IPAA, CD of the pouch can significantly reduce the quality of life. It can cause pouchitis, cuffitis, strictures, deep ulcers, and fistulae, ultimately leading to sepsis or pouch failure,7, 8 and incontinence and anastomotic leaks 9. There may also be an increased risk of malignancy 3.…”