Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis

Imaging in assessing lymph node status in gastric cancer

“…Normal homogeneous uptake of USPIOs in nonmetastatic LNs shortens the T2 and T2*, turning these nodes hypointense on T2-and T2*-weighted images, whereas malignant LNs lack uptake and remain hyperintense. USPIO-enhanced lymphography indeed has been shown to achieve higher diagnostic precision than does conventional, unenhanced MRI for the detection of LN metastases of various tumors [67]. Although no USPIO-enhanced lymphography studies were identifi ed for inclusion in this systematic review, its usefulness in detecting metastatic LNs in gastric cancer has already been demonstrated by a recent pilot study in 17 patients [68].…”

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

“…MR sentinel lymphography with SPIO as a tracer offer better imaging quality, in contrast to the poor spatial resolution of scintigraphy. This may be a promising perspective in cases where preoperative localization will still be needed such as in melanomas of the trunk and head and neck, and recurrent breast cancer, where the lymphatic drainage is sometimes distorted (60,61). Data from a metaanalysis indicate that USPIO have sensitivity and specificity for the detection of axillary involvement of 98% and 96% respectively (62).…”

Functional Imaging of Cancer with Emphasis on Molecular Techniques

“…34 Will et al performed a meta-analysis of prospective studies that compared MRI, with and without ferumoxtran-10, with histological diagnosis after surgery and biopsy and showed that ferumoxtran-10-enhanced MRI is sensitive and specific in detection of nodal metastases for a variety of tumors and offers higher diagnostic precision than unenhanced MRI for detection of lymph node metastases. 37 As such, ferumoxtran-10-enhanced MRI, like PET, has the potential to become a useful clinical functional imaging tool to evaluate lymph nodes of the whole body in the setting of cancer.…”