Diagnostic Potential of Tumor Exosomes

Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have revealed that exosomes play a significant role in intercellular communication and are closely associated with the pathogenesis of disease. Therefore, exosomes are considered promising biomarkers for disease diagnosis. However, exosomes are always mixed with other components of body fluids. Consequently, separation methods for exosomes that allow high‐purity and high‐throughput separation with a high recovery rate and detection techniques for exosomes that are rapid, highly sensitive, highly specific, and have a low detection limit are indispensable for diagnostic applications. For decades, many exosome separation and detection techniques have been developed to achieve the aforementioned goals. However, in most cases, these two techniques are performed separately, which increases operation complexity, time consumption, and cost. The emergence of microfluidics offers a promising way to integrate exosome separation and detection functions into a single chip. Herein, an overview of conventional and microfluidics‐based techniques for exosome separation and detection is presented. Moreover, the advantages and drawbacks of these techniques are compared.

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Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

Lin

Chen

et al. 2019

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232

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Advancements in Nano-Mediated Biosensors: Targeting Cancer Exosome Detection

Tripathi,

Labh,

Katiyar

et al. 2024

J Clust Sci

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Expression Profile of Circulating Exosomal microRNAs in Leukoplakia, Oral Submucous Fibrosis, and Combined Lesions of Leukoplakia and Oral Submucous Fibrosis

Yasothkumar,

Ramani,

Jayaraman

et al. 2024

Head and Neck Pathol

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Diagnostic Potential of Tumor Exosomes

Cited by 3 publications

References 55 publications

Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications

Advancements in Nano-Mediated Biosensors: Targeting Cancer Exosome Detection

Expression Profile of Circulating Exosomal microRNAs in Leukoplakia, Oral Submucous Fibrosis, and Combined Lesions of Leukoplakia and Oral Submucous Fibrosis

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