Diagnostic potential of major and trace elements in the serum of bladder cancer patients

Microelement composition of serum in Dolgans, indigenous inhabitants of the Russian Arctic, in the conditions of industrial development of territories

“…But a statistically significant high content of serum phosphorus was found in women older than 50 years -155 mg/L, which correlates with studies [24]. In a study of patients with bladder cancer, an increase in the concentration of serum phosphorus to 157 mg/L was noted compared with the healthy control group (115 mg/L) [25].…”

“…The typical basal Ti level in human serum was found to be <1 μg/L, while values in the range of 2-6 μg/L were observed for implanted patients [28]. In patients with cancer (0,945 μg/L), a twofold increase in Ti is noted than in healthy patients (0,551) [25].…”

“…It is possible that active employment and the dynamic daily life of reindeer herders and hunters can make young Dolgans more susceptible to heavy metals in the workplace, as well as in the environment. In a study of patients with cancer, an increase in the concentration of serum Ni to 22,5 mg/L was noted, compared with the healthy control group (3,0 mg/L) [25]. For non-smokers in Canada, a positive correlation was found between serum Ni levels and beef kidney consumption [19].…”

Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium

“…A connection between lithium and different bioelements with kidney disturbances was also found in a recent study. The authors reported increased serum level of many elements, such as lithium, calcium, zinc, nickel, strontium and copper, accompanied by decreased iron in patients suffering from bladder cancer compared to healthy control, which led them to the conclusion that lithium, together with other elements like calcium, nickel and strontium, could be potential markers of bladder cancer [35].…”

Determination of major and trace element variability in healthy human urine by ICP-QMS and specific gravity normalisation

“…2 Maintaining the correct balance of essential elements is vital, and imbalances are linked with illness and disease. 3,4 In biology, interactions between different elements, as well as between elements, organic molecules and tissues are intricate and many. [5][6][7] Urine, a product of constant-rate kidney ltration of blood, represents a mixture of water-soluble waste metabolites.…”