Diagnostic pitfalls in needle core biopsy of the breast

Shaaban, Abeer M.

doi:10.1016/j.mpdhp.2021.12.004

Cited by 3 publications

(7 citation statements)

References 19 publications

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“…On rare occasions, fibroadenomas with a prominent myxoid stroma and sparse glandular elements may create an impression of matrix producing carcinoma. Awareness of this potential pitfall and radiology‐pathology correlation should avert misdiagnosis 3 …”

Section: Entities That May Results In Overdiagnosis Of Malignancymentioning

confidence: 99%

“…CKs and p63 are negative. 36 As mentioned earlier, the epithelioid variant of myofibroblastoma may resemble ILC, 3 with further potential for a false-positive diagnosis due to ER positivity (Figure 10).…”

Section: Myofibroblastomamentioning

confidence: 89%

“…Awareness of this potential pitfall and radiology-pathology correlation should avert misdiagnosis. 3 Pleomorphic adenoma is a rare occurrence in the breast that may present a confusing appearance on CNB due to the prominent myxoid stroma containing mildly atypical epithelial cells that may express basal type CKs and are hormone receptor-negative. 6…”

Section: B E N I G N B R E a S T L E S I O N S W I T H M Y X O I D M ...mentioning

confidence: 99%

“…This review aims to highlight pitfalls in the interpretation of breast lesions that may variously lead to underdiagnosis, overdiagnosis, or incorrect classification of malignancy, with potential adverse outcomes for individual patients. The review focusses on interpretation of H&E and IHC in breast pathology and aims to complement existing literature on the subject 2–5 . Molecular pathology characteristics of individual entities are not discussed.…”

Section: Introductionmentioning

confidence: 99%

“…The review focusses on interpretation of H&E and IHC in breast pathology and aims to complement existing literature on the subject. 2 , 3 , 4 , 5 Molecular pathology characteristics of individual entities are not discussed. Similarly, discussion of pitfalls related to non‐operative diagnostic procedures, suboptimal radiology‐pathology correlation, and the quality of sampling at gross examination are beyond the scope of this text.…”

Section: Introductionmentioning

confidence: 99%

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Pitfalls in breast pathology

2022

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Accurate pathological diagnosis is the cornerstone of optimal clinical management for patients with breast disease. As non-operative diagnosis has now become the standard of care, histopathologists encounter the daily challenge of making definitive diagnoses on limited breast core needle biopsy (CNB) material. CNB samples are carefully evaluated using microscopic examination of haematoxylin and eosin (H&E)-stained slides and supportive immunohistochemistry (IHC), providing the necessary information to inform the next steps in the patient care pathway. Some entities may be difficult to distinguish on small tissue samples, and if there is uncertainty a diagnostic excision biopsy should be recommended. This review discusses (1) benign breast lesions that may mimic malignancy, (2) malignant conditions that may be misinterpreted as benign, (3) malignant conditions that may be incorrectly diagnosed as primary breast carcinoma, and (4) some IHC pitfalls. The aim of the review is to raise awareness of potential pitfalls in the interpretation of breast lesions that may lead to underdiagnosis, overdiagnosis, or incorrect classification of malignancy with potential adverse outcomes for individual patients.

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Section: Entities That May Results In Overdiagnosis Of Malignancymentioning

confidence: 99%

Section: Myofibroblastomamentioning

confidence: 89%

Section: B E N I G N B R E a S T L E S I O N S W I T H M Y X O I D M ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pitfalls in breast pathology

2022

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Practical approach to diagnosis of breast lesions with heterologous components

Shaaban,

Quinn,

Rakha

2024

Diagnostic Histopathology

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Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature

Elghobashy,

Jenkins,

Shulman

et al. 2023

Biomedicines

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Background: Tall cell carcinoma of the breast with reversed polarity (TCCRP) is a rare type of invasive breast cancer with overlapping features with papillary thyroid carcinoma and a characteristic molecular profile. Few cases have been reported in the literature since the first case was described in 2003. Case presentation: We present the case of a 41-year-old female with a symptomatic left breast lump. Image-guided core biopsy was diagnosed as triple-negative apocrine carcinoma. Surgical excision revealed an invasive carcinoma with solid papillary pattern, nuclei arranged away from the basement membrane (reversed polarity) and luminal eosinophilic colloid-like material. The tumour was GATA3-, CK5-, CK14- and CK7-positive and TTF1-negative. Specialist opinion and the identification of hotspot mutations in the IDH2 p.Arg172 gene via PCR confirmed the diagnosis of TCCRP. Conclusions: TCCRP is a relatively recently recognised papillary epithelial neoplasm with characteristic morphological features and molecular profile. Due to its rarity, TCCRP can be diagnostically challenging, and features can be mistaken for benign and malignant lesions. Accurate diagnosis is important in effective treatment of this indolent malignant triple-negative breast cancer, which carries an excellent prognosis.

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Diagnostic pitfalls in needle core biopsy of the breast

Cited by 3 publications

References 19 publications

Pitfalls in breast pathology

Pitfalls in breast pathology

Practical approach to diagnosis of breast lesions with heterologous components

Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature

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