Diagnostic Performance of the HCV Core Antigen Test To Identify Hepatitis C in HIV-Infected Patients: a Systematic Review and Meta-Analysis

Sepúlveda‐Crespo, Daniel; Treviño‐Nakoura, Ana; Bellón, José M.; Jiménez-Sousa, María Ángeles; Ryan, Pablo; Martı́nez, Isidoro; Fernández‐Rodríguez, Amanda; Resino, Salvador

doi:10.1128/jcm.01331-22

J Clin Microbiol

2023

DOI: 10.1128/jcm.01331-22

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Diagnostic Performance of the HCV Core Antigen Test To Identify Hepatitis C in HIV-Infected Patients: a Systematic Review and Meta-Analysis

Daniel Sepúlveda‐Crespo

Ana Treviño‐Nakoura

José M. Bellón

et al.

Abstract: The standard algorithm for diagnosing hepatitis C virus (HCV) infection has two steps, an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. However, the HCV core antigen (HCVcAg) detection assay is an alternative for one-step diagnosis.

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Estimates of Hepatitis C Seroprevalence and Viremia in State Prison Populations in the United States

Spaulding,

Kennedy,

Osei

et al. 2023

The Journal of Infectious Diseases

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Background Prior studies demonstrate that eliminating hepatitis C virus (HCV) in the United States (US) heavily depends on treating incarcerated persons. Knowing the scope of the carceral HCV epidemic by state will help guide national elimination efforts. Methods Between 2019 and 2023, all state prison systems received surveys requesting data on hepatitis C antibody and viremic prevalence. We supplemented survey information with publicly available HCV data to corroborate responses and fill in data gaps. Results Weighting HCV prevalence by state prison population size, we estimate that 15.2% of the US prison population is HCV seropositive and 8.7% is viremic; 54.9% of seropositive persons have detectable RNA. Applying prevalence estimates to the total prison population at year-end 2021, 91 090 persons with HCV infection resided in a state prison. Conclusions With updated and more complete HCV data from all 50 states, HCV prevalence in state prisons is nearly 9-fold higher than the US general population. The heterogeneity in HCV prevalence by state prison system may reflect variable exposure before arrest and/or differences in treatment availability during incarceration. Elimination of HCV in the country depends on addressing the carceral epidemic, and one of the first steps is understanding the size of the problem.

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Estimates of Hepatitis C Seroprevalence and Viremia in State Prison Populations in the United States

Spaulding,

Kennedy,

Osei

et al. 2023

The Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

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Diagnostic Performance of the HCV Core Antigen Test To Identify Hepatitis C in HIV-Infected Patients: a Systematic Review and Meta-Analysis

Abstract: The standard algorithm for diagnosing hepatitis C virus (HCV) infection has two steps, an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. However, the HCV core antigen (HCVcAg) detection assay is an alternative for one-step diagnosis.

Cited by 1 publication

References 41 publications

Estimates of Hepatitis C Seroprevalence and Viremia in State Prison Populations in the United States

Estimates of Hepatitis C Seroprevalence and Viremia in State Prison Populations in the United States

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