Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer

Koi, Yumiko; Tsutani, Yasuhiro; Nishiyama, Yukie; Kanda, Miyuki; Shiroma, Yoshitomo; Yamamoto, Yoshiya; Sasada, Shinsuke; Akita, Tomoyuki; Masumoto, Norio; Kadoya, Takayuki; Takahashi, Ryou‐u; Tanaka, Junko; Okada, Minoru; Tahara, Hidetoshi

doi:10.1111/cas.14378

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Although there was no significant association between G-tail TL and baPWV in the adjusted models, we identified a clear decreasing trend of baPWV with a longer total TL or G-tail TL (Table 3). The G-tail structures might be more sensitive to the magnitude of individual differences in cellular variability than total TLs [28][29][30]. Nevertheless, the results are in line with prior reports that a shorter TL was associated with arterial stiffness [17,19,[24][25][26].…”

Section: Discussionsupporting

confidence: 91%

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Wai

Sawada

Itoh

et al. 2021

JPM

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Telomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial–ankle pulse wave velocity (baPWV). This population-based cross-sectional study involved 1065 individuals in the Iwaki area, Japan. Total TL length and TL G-tail length were measured by hybridization protection assay. The baPWV was measured on the right and left sides using a non-invasive vascular screening device. The associations between TL and baPWV were assessed by multivariate linear regression. Compared with the shortest total TL tertile, the longest total TL group showed a significant decrease in baPWV (lowest vs. highest tertile: adjusted beta: −41.24, 95% confidence interval (CI): −76.81, −5.68). The mean baPWV decreased with a longer TL (TL G-tail length: p trend < 0.001, total TL: p trend < 0.001). TL G-tail and total TL lengths were inversely associated with baPWV, implicating TL shortening in the development of CVD. This study provides evidence of the factors influencing CVD risks at a very early stage when individuals can still take necessary precautions before CVD gives rise to a symptomatic health outcome.

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Section: Discussionsupporting

confidence: 91%

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Wai

Sawada

Itoh

et al. 2021

JPM

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“…Several clinical studies have shown that the leukocyte telomeric sequence length reflects the length of other cell types in the body, a process known as synchrony [17][18][19]. Consistent with these studies, we reported that the telomere shortening and/or telomeric G-tail shortening is associated with aging and age-related diseases, including white matter lesions, endothelial dysfunction, and cancer [20][21][22][23]. In breast cancer, the telomeric G-tail length is shorter in patients at an early stage than in healthy individuals, suggesting that the telomeric G-tail length is a promising blood-based biomarker for the diagnosis of cancer.…”

Section: Introductionsupporting

confidence: 86%

“…Therefore, dysfunction or the shortening of telomeres and the G-tail length is considered to cause age-related diseases [26]. Consistent with these findings, our previous studies reported that the Gtail shortening is associated with the onset and progression of several diseases, such as cardiovascular disease and breast cancer [22,23]. Since the LTL is not consistently associated with EAC [27], the effect of the LTL on ESC is debated.…”

Section: Discussionmentioning

confidence: 84%

Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence

Han

Hayashi

Takahashi

et al. 2022

JCM

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Despite significant advances in therapeutics for esophageal cancer (ESC) in the past decade, it remains the sixth most fatal malignancy, with a poor 5-year survival rate (approximately 10%). There is an urgent need to improve the timely diagnosis to aid the prediction of the therapeutic response and prognosis of patients with ESC. The telomeric G-tail plays an important role in the chromosome protection. However, aging and age-related diseases lead to its shortening. Therefore, the G-tail length has been proposed as a novel potential biomarker. In the present study, to examine the possibility of G-tail shortening in patients with ESC, we measured the leukocyte telomere length (LTL) and the G-tail length using a hybridization protection assay in 147 patients with ESC and 170 age-matched healthy controls. We found that the G-tail length in patients with ESC was shorter than that in the healthy controls (p = 0.02), while the LTL shortening was not correlated with the ESC incidence and recurrence. Our results suggest that the G-tail length reflects the physiological status of patients with ESC and is a promising biomarker for the diagnosis and prognosis of ESC.

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“…The average coefficient of variance for the G-tail was 4.0%. 31 The length of the G-tail was represented in logarithmic notation.…”

Section: Methodsmentioning

confidence: 99%

Association Between Telomere G-Tail Length and Coronary Artery Disease or Statin Treatment in Patients With Cardiovascular Risks　― A Cross-Sectional Study ―

et al. 2023

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Background: The utility of telomere G-tail length to predict coronary artery disease (CAD) remains controversial. CAD results from coronary artery narrowing due to cholesterol and lipid accumulation, augmented by inflammatory cells and other factors. This study explored the significance of telomere G-tail length in suspected CAD patients. Methods and Results: In all, 95 patients with suspected CAD or ≥1 cardiac risk factor underwent coronary computed tomography angiography (CCTA). We measured leukocyte telomere length and G-tail length using a hybrid protection method, and diagnosed the presence of CAD using CCTA. Associations between G-tail length and the presence of CAD, the number of stenosed coronary arteries, and brachial-ankle pulse wave velocity (baPWV) were analyzed. No significant difference was observed in G-tail length when comparing groups with or without CAD or statin treatment. However, in the non-statin group, G-tail length was significantly shorter in patients with 3-vessel disease compared with 1-vessel disease. Dividing the group using a baPWV of 1,300 cm/s, telomere G-tail length was significantly shorter in the high-risk (baPWV ≥1,300 cm/s) group. Conclusions: The clinical utility of telomere G-tail length as a CAD risk indicator seems limited. There was a trend for longer telomere G‐tail length in the statin‐treated group. Moreover, telomere G-tail length was reduced in patients at high-risk of cardiovascular events, aligning with the trend of a shortening in telomere G-tail length with CAD severity.

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Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer

Cited by 8 publications

References 25 publications

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence

Association Between Telomere G-Tail Length and Coronary Artery Disease or Statin Treatment in Patients With Cardiovascular Risks　― A Cross-Sectional Study ―

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Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer

Cited by 8 publications

References 25 publications

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study

Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence

Association Between Telomere G-Tail Length and Coronary Artery Disease or Statin Treatment in Patients With Cardiovascular Risks ― A Cross-Sectional Study ―

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Association Between Telomere G-Tail Length and Coronary Artery Disease or Statin Treatment in Patients With Cardiovascular Risks　― A Cross-Sectional Study ―