Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

Zhao, Yanhua; Xia, Junxiang; He, He; Liang, Shanshan; Zhang, He; Gan, Weiqun

doi:10.3389/fendo.2022.981196

Cited by 15 publications

(22 citation statements)

References 42 publications

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“…For example, HDL-c can induce an anti-inflammatory response in macrophages through cholesterol efflux-mediated mechanisms ( 48 ). Our study found that the NAFLD group had a higher percentage of male gender (79.3%) than female gender (20.7%), indicating that male gender has a higher risk of developing NAFLD than female, consistent with previous research ( 49 ). Platelets are shown to promote hepatic steatosis, inflammation, and injury in both the early and late stages of NAFLD ( 32 ).…”

Section: Discussionsupporting

confidence: 92%

Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Bao,

Xu,

Sun

et al. 2024

Front. Nutr.

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ObjectiveGiven the high prevalence of non-alcoholic fatty liver disease (NAFLD) and its potential to progress to liver fibrosis, it is crucial to identify the presence of NAFLD in patients to guide their subsequent management. However, the current availability of non-invasive biomarkers for NAFLD remains limited. Therefore, further investigation is needed to identify and develop non-invasive biomarkers for NAFLD.MethodsA retrospective analysis was conducted on 11,883 patients admitted to the Healthcare Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2016 to December 2019 and divided into NAFLD and non-NAFLD groups. Anthropometric and laboratory examination data were collected. The correlations between variables and NAFLD were evaluated using the student’s t-test or Mann–Whitney U test and binary logistic regression analysis. The predictive ability of these variables for NAFLD was assessed using the areas under the curves (AUCs) of receiver operating characteristics.ResultsAmong the included patients, 3,872 (32.58%) were diagnosed with NAFLD, with 386 (9.97%) individuals having liver fibrosis. Patients with NAFLD exhibited a higher proportion of males, elevated body mass index (BMI), and increased likelihood of hypertension, diabetes mellitus, and atherosclerosis. Logistic regression analysis identified the neutrophil to albumin ratio (NAR) as the most promising novel inflammation biomarkers, with the highest AUC value of 0.701, a cut-off value of 0.797, sensitivity of 69.40%, and specificity of 66.00% in identifying the risk of NAFLD. Moreover, NAR demonstrated superior predictive value in identifying NAFLD patients at risk of liver fibrosis, with an AUC value of 0.795, sensitivity of 71.30%, and specificity of 73.60% when NAR reached 1.285.ConclusionThese findings highlight that the novel inflammatory biomarker, NAR, is a convenient and easily accessible non-invasive predictor for NAFLD and NAFLD with liver fibrosis.

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Section: Discussionsupporting

confidence: 92%

Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Bao,

Xu,

Sun

et al. 2024

Front. Nutr.

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“…Finally, the diagnostic value of all SI indicators in MAFLD/NAFLD diagnosis were evaluated. Both logistic regression and RCS analyses showed that CRP, WBC, MONO, and LMR were positively associated with the prevalence of MAFLD and NAFLD, while PLR showed an inverse association, which is consistent with previous studies [ 43 – 46 ]. In the ROC analysis, the AUC values of CRP, WBC, LYMPH, ALI, and CA ranged from 0.60 to 0.63 in both MAFLD and NAFLD prediction, and the AUC values of other SI indicators were all less than 0.60.…”

Section: Discussionsupporting

confidence: 91%

Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study

Liu,

Han,

et al. 2023

Lipids Health Dis

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Background Variations in the prevalence and systemic inflammatory (SI) status between non-alcoholic fatty liver disease (NAFLD) and newly defined metabolic dysfunction-associated fatty liver disease (MAFLD) have only been reported by few studies. Hence, this study aimed to compile data on the prevalence and the systemic inflammation levels of MAFLD and NAFLD in a general population from Southeast China was summarized to explore the potential effect of the transformation of disease definition. Methods A total of 6718 general population participants aged 35–75 were enrolled. Logistic regression and restricted cubic spline (RCS) models were used to examine the relationship between 15 SI indicators and NAFLD and MAFLD. The predicted values of MAFLD and NAFLD were analyzed using the receiver operating characteristic (ROC) curve. Results The prevalence of MAFLD and NAFLD was 34.7% and 32.4%, respectively. Their overlapping rate was 89.7%, while only 8.3% and 1.9% of participants were MAFLD-only and NAFLD-only. Among three FLD groups, the MAFLD-only group had the highest levels of 8 SI indicators, including CRP, WBC, LYMPH, NEUT, MONO, ALB, NLR, and SIRI. The non-FLD group had the lower levels of all 15 SI indicators compared with all FLD subgroups. The odds ratios (ORs) of 10 SI indicators were significant in both multivariable-adjusted logistic regression and RCS analyses of MAFLD or NAFLD, including CRP, WBC, LYMPH, NEUT, MONO, ALB, PLR, LMR, ALI and CA. ROC analysis showed that the AUC values of all SI were lower than 0.7 in both MAFLD and NAFLD. Conclusions MAFLD could cover more FLD than NAFLD, and the MAFLD-only group had a more severe inflammation status, whereas the NAFLD-only exhibited lower levels. Moreover, there was not a high AUC and a high sensitivity of SI indicators, suggesting that SI indicators are not good indicators to diagnose NAFLD/MAFLD.

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“…Finally, we evaluated the diagnostic value of all SI indicators in MAFLD/NAFLD diagnosis. Both logistic regression and RCS analyses showed that CRP, WBC, MONO, and LMR were positively associated with the prevalence of MAFLD and NAFLD, while PLR showed an inverse association, which is consistent with previous studies [37][38][39][40]. In the ROC analysis, the AUC values of CRP, WBC, LYMPH, ALI, and CA ranged from 0.60 to 0.63 in both MAFLD and NAFLD prediction, and the AUC values of other SI indicators were all less than 0.60.…”

Section: Discussionsupporting

confidence: 91%

Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study

Liu

Han²,

et al. 2023

Preprint

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Background The difference in prevalence and systemic inflammatory (SI) status from non-alcoholic fatty liver disease (NAFLD) to newly defined metabolic dysfunction-associated fatty liver disease (MAFLD) was less reported. Therefore, we estimated the prevalence and summarized the systemic inflammation levels of MAFLD and NAFLD in a general population from Southern China to explore the potential effect of the transformation of disease definition. Methods In total, 6718 subjects aged 35–74 years old from a general population cohort were enrolled. Logistic regression and restricted cubic spline (RCS) models were used to examine the relationship between 15 SI indicators and NAFLD and MAFLD. The receiver operating characteristic (ROC) curve was used to investigate their predictive value for MAFLD and NAFLD. Results The prevalence of MAFLD and NAFLD was 34.7% and 32.4%, respectively. Their overlapping rate was 89.7%, while only 8.3% and 1.9% of participants were MAFLD-only and NAFLD-only. Among three FLD groups, the MAFLD-only group had the highest levels of 8 SI indicators. The non-FLD group had the lower levels of all 15 SI indicators compared with all FLD subgroups. The odds ratios (ORs) of 10 SI indicators were significant in both multivariable-adjusted logistic regression and RCS analyses of MAFLD or NAFLD. ROC analysis showed that the AUC values of all SI were lower than 0.7 in both MAFLD and NAFLD. Conclusions MAFLD could cover more FLD than NAFLD, and the MAFLD-only group had a more severe inflammation status, whereas the NAFLD-only exhibited lower levels.

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Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

Cited by 15 publications

References 42 publications

Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study

Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study

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