Diagnostic performance of neutrophil CD64 index in patients with sepsis in the intensive care unit

Ye, Zhenglong; Zou, Hui; Liu, Shangxiang; Mei, Chengqing; Chang, Xiaoliang; Hu, Zhiqing; Yang, Huanhuan; Wu, Yong

doi:10.1177/0300060519860677

Cited by 16 publications

(17 citation statements)

References 22 publications

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“…For example, Dai et al (10) performed a meta-analysis including 7 studies in neonates with pooled sensitivity and specificity of 80% (95% CI: 69-88%) and 83% (95% CI: 71-90%), respectively. Ye et al (14) reported a sensitivity of 83% and specificity of 88% in diagnosing sepsis in 62 adult ICU patients. Groselj-Grenc et al (15) reported the diagnostic performance of the nCD64 index with a sensitivity of 86% and specificity of 100% in children.…”

Section: Discussionmentioning

confidence: 99%

Assessment of continuous neutrophil CD64 index measurement for diagnosing sepsis and predicting outcome in a Chinese pediatric intensive care unit: a prospective study

Cui¹,

Xu²,

Fang³

et al. 2021

Transl Pediatr

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Background: The high affinity immunoglobulin-Fc fragment receptor I CD64 on neutrophils is widely assumed to be a useful biomarker in the early identification of sepsis, and it improves outcomes. We aimed to determine its ability to diagnose sepsis and predict its prognosis with continuous measurements.Methods: A total of 335 patients admitted to a Chinese PICU were prospectively stratified into two groups according to the presence of sepsis (defined by clinical criteria for sepsis) between 2018 and 2019. Serum concentrations of the nCD64 index, C-reactive protein (CRP), and procalcitonin (PCT) were measured.Sensitivity, specificity and receiver operating characteristic (ROC) curves were calculated to evaluate the diagnostic value for sepsis. A multiple logistic regression model was used to estimate the prognostic value of continuous nCD64 index measurement for in-hospital death.Results: The baseline nCD64 index and levels of PCT and CRP were significantly higher in septic children than in nonseptic children (P<0.05). The nCD64 index presented a higher sensitivity (0.90), specificity (0.78) and area under the ROC curve [0.91 (0.90, 0.93)] than CRP and PCT in discriminating septic children with an optimal cutoff value of 5.78. The nCD64 index decreased with the progression of sepsis, and the baseline nCD64 index was strongly associated with in-hospital death (OR: 2.18, 95% CI: 1.02-4.74). Moreover, the more rapidly the nCD64 index declined, the lower the in-hospital death rate was (OR: 0.89, 95% CI: 0.63-1.35) after adjusting for the baseline nCD64 index and other confounders.Conclusions: The nCD64 index was not only effective for the early diagnosis of childhood sepsis but also positively associated with the prognosis of sepsis. Moreover, the nCD64 decline was inversely associated with the in-hospital death rate.

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Section: Discussionmentioning

confidence: 99%

Assessment of continuous neutrophil CD64 index measurement for diagnosing sepsis and predicting outcome in a Chinese pediatric intensive care unit: a prospective study

Cui¹,

Xu²,

Fang³

et al. 2021

Transl Pediatr

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“…CRP is an acute-phase protein that increases within 4 to 6 hours upon stimulation by pro-in ammatory cytokines and peaks at 36 to 50 hours [13] . CRP is often used for early diagnosis of infection and as a bacterial biomarker for sepsis [14] , but it has relatively low speci city [13] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Neutrophil CD64 Index in Elderly Patient with Community-acquired Pneumonia

Cao

Suhang-Wang

et al. 2021

Preprint

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Background: Elderly patient with community-acquired pneumonia is the leading infectious cause of death. During the clinical diagnosis and treatment, some elderly patients do not have typical clinical symptoms .Therefore establishment of safe and effective diagnosis, prognostic assessment systems is important for clinicians. Objective: To evaluate the diagnostic and prognostic value of the neutrophil CD64(nCD64) in elderly patients with community-acquired pneumonia. Methods: One hundred and twenty-eight elderly patients(≥65year) diagnosed with community-acquired pneumonia from December 2018 to December 2020. All patients were further subdivided into two groups: Non severe community-acquired pneumonia(N-SCAP) group and severe community-acquired pneumonia (SCAP)group. nCD64 index, procalcitonin (PCT) level, C-reactive protein (CRP) level, White blood cell (WBC) counts and Neutrophil (NEUT) absolute counts were obtained and CURB-65 scores were calculated for each patient. Results: The nCD64, CRP ,PCT, WBC,NEUT levels,CURB-65 score were higher in severe community-acquired pneumonia group patients. The nCD64, CRP, PCT levels ,CURB-65 score were higher in non-survivors. The receiver operating characteristic (ROC) curve of nCD64 was higher than those of CRP, PCT, WBC, NEUT levels for diagnosing infection. The AUC of nCD64 for predicting 28-day mortality in community-acquired pneumonia was significantly higher than those of CRP ,PCT, WBC and NEUT. The AUC of nCD64 combined with CURB-65 score was significantly higher than that of CRP, PCT, WBC and NEUT parameter combined with CURB-65 score for predicting 28-day mortality. Conclusions: The neutrophil CD64 index is a valuable biomarker for diagnosis of infection and prognostic evaluation in elderly patients (≥65 year) with community-acquired pneumonia.

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“…For clinical operation, this is based on change in SOFA score in patients with known or suspected infection. In a recent retrospective study, 39 diagnostic accuracy of CD64, PCT, and CRP was evaluated for sepsis identification in 35 adult ICU patients and compared with 27 controls (underwent coronary bypass surgery). Sepsis 3 criteria were used for sepsis identification.…”

Section: Discussionmentioning

confidence: 99%

“…But, this study has limitations of small sample size and retrospective in nature. 39 Till now, no literature is there describing CD64 as a prognostic marker or sepsis as per sepsis 3 criteria.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil CD64 a Diagnostic and Prognostic Marker of Sepsis in Adult Critically Ill Patients: A Brief Review

Patnaik

Azim

Agarwal

2020

Indian Journal of Critical Care Medicine

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Diagnostic performance of neutrophil CD64 index in patients with sepsis in the intensive care unit

Cited by 16 publications

References 22 publications

Assessment of continuous neutrophil CD64 index measurement for diagnosing sepsis and predicting outcome in a Chinese pediatric intensive care unit: a prospective study

Assessment of continuous neutrophil CD64 index measurement for diagnosing sepsis and predicting outcome in a Chinese pediatric intensive care unit: a prospective study

Effect of Neutrophil CD64 Index in Elderly Patient with Community-acquired Pneumonia

Neutrophil CD64 a Diagnostic and Prognostic Marker of Sepsis in Adult Critically Ill Patients: A Brief Review

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