Diagnostic performance of MDCT, PET/CT and gadoxetic acid (Primovist®)-enhanced MRI in patients with colorectal liver metastases being considered for hepatic resection: initial experience in a single centre

Chan, Victor; Das, Jeeban Paul; Gerstenmaier, Jan; Geoghegan, Justin; Gibney, R G; Collins, Conor D; Skehan, Stephen J.; Malone, Dermot E.

doi:10.1007/s11845-012-0805-x

Cited by 24 publications

(16 citation statements)

References 93 publications

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“…5D). However, the cost-benefit ratio for performing a single evaluation of the whole abdomen with P-MRI remains unclear [27][28][29]. Volumetric calculation is operator dependent and crucial to prevent PHLF postsurgery.…”

Section: Discussionmentioning

confidence: 99%

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in colorectal liver metastasis: the radiologist’s perspective

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in colorectal liver metastasis: the radiologist’s perspective

et al. 2016

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“…The diagnostic accuracy of MRI and CT for detecting liver metastasis has been established in patients with colorectal cancer and other cancers . Several studies have found that the sensitivity of CE‐MRI is superior to CE‐CT, with equivalent specificity . A linked evidence approach was taken to inform the diagnostic accuracy and change in management associated with CE‐MRI.…”

Section: Methodsmentioning

confidence: 99%

“…A linked evidence approach was taken to inform the diagnostic accuracy and change in management associated with CE‐MRI. The sensitivity of MRI and CT was estimated by pooling information on diagnostic accuracy from five studies by meta‐analysis using a random effects model . The pooled sensitivity for MRI (gadoxetic acid) was 0.943 (95% CI: 0.91, 0.96) and CE‐CT was 0.768 (95% CI: 0.67, 0.84).…”

Section: Methodsmentioning

confidence: 99%

“…Other benefits of MRI compared with CT include avoidance of ionizing radiation and better image quality in soft tissue . For patients with colorectal cancer, several studies have demonstrated that CE‐MRI had superior sensitivity and equivalent specificity to CE‐CT . This may make MRI better suited to the characterization of potential colorectal liver metastasis.…”

Section: Introductionmentioning

confidence: 99%

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Cost‐effective imaging for resectability of liver lesions in colorectal cancer: an economic decision model

Saing

Haywood

Duncan

et al. 2017

ANZ Journal of Surgery

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“…A meta-analysis of prospective studies demonstrated a superior performance of MRI over FDG-PET and CT on a lesion-by-lesion basis in the detection of hepatic metastases and in particular for lesions less than 1 cm in size (sensitivity 80%-88% and specificity 93%-97%) [4]. The reported sensitivity of hepatocyte specific contrast enhanced MRI for the detection of hepatic metastases ranged between 91% and 97% compared with 71% and 73.5% for CT [5], [6], [7]. The reported sensitivity of hepatocyte-specific contrast agents in the detection of hepatic metastases from gastrointestinal malignancies was significantly improved by adding 10-minute or 20-minute delayed hepatobiliary phase images to the standard multiphase exam after gadoxetate disodium [8].…”

Section: Introductionmentioning

confidence: 99%

Arterial Phase with CAIPIRINHA-Dixon-TWIST (CDT)–Volume-Interpolated Breath-Hold Examination (VIBE) in Detecting Hepatic Metastases

Han

Zhang

et al. 2017

Translational Oncology

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PURPOSE: To evaluate lesion enhancement performance of Multi-Arterial CAIPIRINHA-Dixon-TWIST–Volume-Interpolated Breath-Hold Examination (MA-CDT-VIBE) for the detection of hepatic metastases. MATERIALS AND METHODS: Thirty-one patients with suspicious hepatic metastases were enrolled in this retrospective study. Two independent radiologists scored visualization of each lesion on a scale of 1 (poor visualization) to 11 (excellent visualization) on 11 sets of images. These included 6 hepatic arterial sub-phases acquired in one breath-hold, 1 series of the mean of 6 hepatic arterial sub-phases, 3 subtracted arterial sub-phases, and 1 portal venous phase. The phases with good (score 8–10) and excellent (score 11) lesion visualization were identified, and the number of lesions seen on each of these phases was compared to the number of lesions that was seen best on the equivalent-to-conventional single arterial phase as well as to those that were see best on the mean of 6 hepatic arterial sub-phases. Inter-reader agreement was also calculated. RESULTS: The MA-CDT-VIBE was successfully acquired in 25 patients with hypervascular metastases (96 lesions) and 6 patients with hypovascular metastases (13 lesions). In case of hypervascular metastases, the 6th/6 arterial sub-phase had excellent lesion visualization (sore of 11) in 56 and 44 lesions for the 2 readers, respectively. Good lesion visualization (score of 8-10) was recorded in 5th/6 arterial subphases, in 81 and 67 lesions for the 2 readers, respectively. In case of hypovascular metastases, the portal venous phase had excellent lesion visualization (sore of 11) in all 13 lesions for the 2 readers. Good lesion visualization (score of 8–10) was recorded in 12 and 13 lesions on the 5th/6 and 6th/6 arterial subphases, respectively. More hypervascular lesions scored good (score of 8–10) and excellent (score of 11) on the 5th/6 and 6th/6 phases of MA-CDT-VIBE compared with the equivalent-to-conventional single arterial phase (3rd/6) and the set with mean of 6 hepatic arterial sub-phases. The results were statistically significant (t test, P < .0001). Inter-reader agreement was good for hypervascular lesions (kappa = 0.627, P < .0001) and excellent for hypovascular lesions (kappa = 1.0, P < .0001), respectively. CONCLUSIONS: The MA-CDT-VIBE improves lesion conspicuity by providing a wide observation window for hypervascular lesions. For hypovascular lesions, the advantage of multiple arterial sub-phases over the portal venous phase is not apparent.

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Diagnostic performance of MDCT, PET/CT and gadoxetic acid (Primovist®)-enhanced MRI in patients with colorectal liver metastases being considered for hepatic resection: initial experience in a single centre

Cited by 24 publications

References 93 publications

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in colorectal liver metastasis: the radiologist’s perspective

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in colorectal liver metastasis: the radiologist’s perspective

Cost‐effective imaging for resectability of liver lesions in colorectal cancer: an economic decision model

Arterial Phase with CAIPIRINHA-Dixon-TWIST (CDT)–Volume-Interpolated Breath-Hold Examination (VIBE) in Detecting Hepatic Metastases

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