Diagnostic Performance of Magnetic Resonance Imaging and Computed Tomography for Advanced Retinoblastoma

Jong, Marcus C. de; Graaf, Pim de; Noij, Daniel P.; Göricke, Sophia; Maeder, Philippe; Galluzzi, Paolo; Brisse, H.; Moll, Annette C.; Castelijns, Jonas A.

doi:10.1016/j.ophtha.2013.11.021

Cited by 63 publications

(58 citation statements)

References 46 publications

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“…imaging for the detection of metastatic risk factors is not perfect, but with the increasing use of eye-sparing treatment regimens, MR imaging is the only source of information to justify the choice of treatment (5,26). Previous, generally smaller studies have shown that there is an association between tumor size and tumor extent (26)(27)(28)(29).…”

Section: Head and Neck Imaging: Tumor Size Used To Predict Tumor Extementioning

confidence: 99%

“…(4)(5)(6)(7). Massive choroidal invasion (invasion of at least 3 mm in terms of thickness or width of the tumor into the choroid or touching the sclera [8]), scleral invasion, and postlaminar optic nerve invasion (PLONI) are considered metastatic risk factors (especially concomitant PLONI and massive choroidal or scleral invasion) (9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Advances In Knowledgementioning

confidence: 99%

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Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma

Jong

Meer²,

Göricke

et al. 2016

Radiology

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).q RSNA, 2015 Purpose:To assess the correlation of intraocular retinoblastoma tumor size measured with magnetic resonance (MR) imaging in the prediction of histopathologically determined metastatic risk factors (postlaminar optic nerve invasion and massive choroidal invasion). Materials and Methods:The ethics committee approved this retrospective multicenter study with a waiver of informed consent. The study population included 370 consecutive patients with retinoblastoma (375 eyes) who underwent baseline MR imaging, followed by primary enucleation from 1993 through 2014. Tumor sizes (maximum diameter and volume) were measured independently by two observers and correlated with histopathologic risk factors. Receiver operating characteristic curves were used to analyze the diagnostic accuracy of tumor size, and areas under the curve were calculated. Logistic regression analysis was performed to evaluate potential confounders. Results:Receiver operating characteristic analysis of volume and diameter, respectively, yielded areas under the curve of 0. Conclusion:Intraocular tumor size shows a strong association with postlaminar optic nerve invasion and a moderate association with massive choroidal invasion. These findings provide diagnostic accuracy measures at different size cutoff levels, which could potentially be useful in a clinical setting, especially within the scope of the increasing use of eye-salvage treatment strategies.q RSNA, 2015

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Section: Head and Neck Imaging: Tumor Size Used To Predict Tumor Extementioning

confidence: 99%

Section: Advances In Knowledgementioning

confidence: 99%

Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma

Jong

Meer²,

Göricke

et al. 2016

Radiology

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“…All initial diagnostic work-ups should include whole-brain T2, T1 precontrast sequences, and T1 postcontrast sequences to evaluate for CSF seeding, pineal involvement, or suprasellar involvement because this guides treatment objectives (see Table 8). [33][34][35] Differential considerations include Coats disease, ocular toxocariasis, astrocytic hamartoma, medulloepithelioma, or choroidal hemangioma. Imaging recommendations for retinoblastoma US may serve as the initial tool for evaluation of intraocular mass in conjunction with ophthalmologic examination.…”

Section: Nfi: Pearls For the Referring Clinicianmentioning

confidence: 99%

“…Medulloepithelioma arises from the ciliary neuroepithelium and usually presents with cystic component without internal calcifications. Choroidal hemangiomas have the characteristic T1/T2 hyperintense signal and avid postcontrast enhancement (Box 14) [33][34][35]. …”

mentioning

confidence: 99%

Common Pediatric Head and Neck Congenital/Developmental Anomalies

LaPlante

Pierson

Hedlund

2015

Radiologic Clinics of North America

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“…In retinoblastoma patients, MRI is used to evaluate for local extraocular spread, optic nerve involvement, secondary malignancy and intracranial 'trilateral' tumors, as well as monitor these patients' disease over time [58]. However, optic nerve enhancement, as detected by MRI, must be interpreted with caution as many false positives may occur [59].…”

Section: Adjunctive Imagingmentioning

confidence: 99%

Imaging the intraocular tumor

Seider

Damato²

2014

Expert Review of Ophthalmology

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Imaging the intraocular tumor is multi-modal, multi-purposed, evolving and essential in the detection, diagnosis and surveillance of intraocular tumors. The most useful modalities for imaging intraocular tumors are drawing, photography, ultrasound and optical coherence tomography. A primary purpose of imaging the intraocular tumor is to document its precise appearance (and that of its secondary effects) at a point in time, thus permitting sequential images to accurately document change. However, an equally important reason for imaging is to gather diagnostic information that cannot be obtained from ophthalmic examination alone. The specific utility of each available imaging modality depends on the patient, tumor and ability of the clinician to interpret the data produced.

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Diagnostic Performance of Magnetic Resonance Imaging and Computed Tomography for Advanced Retinoblastoma

Cited by 63 publications

References 46 publications

Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma

Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma

Common Pediatric Head and Neck Congenital/Developmental Anomalies

Imaging the intraocular tumor

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