Diagnostic performance of kidney injury molecule‐1 for detection of abnormal urinary albumin‐to‐creatinine ratio in type 2 diabetes mellitus

Abd-Elraheem, Sabah; Ahmed, Niveen; Zahran, Fawkia E.; Mohammed, Gamal; Ibrahim, El Sayed Ibrahim

doi:10.1080/15321819.2021.1954947

Cited by 3 publications

(2 citation statements)

References 16 publications

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“… 10 , 26 , 27 urine KIM-1 was also associated with adverse heart failure outcomes and longitudinal kidney function decline among persons with and without diabetes mellitus in some prospective studies. 27 – 31 However, few studies examined these associations in specific high-risk populations, such as those with diabetes mellitus and eGFR <60 ml/min per 1.73 m 2 or that included a large proportion of Black persons.…”

Section: Discussionmentioning

confidence: 99%

Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus

et al. 2023

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Background: Kidney disease assessed by serum creatinine and albuminuria are strongly associated with mortality in diabetes. These markers primarily reflect glomerular function and injury. Urine biomarkers of kidney tubule health were recently associated with the risk of kidney failure in individuals with chronic kidney disease (CKD) and diabetes. Associations of these biomarkers with risk of death are poorly understood. Methods: In 560 individuals with diabetes and estimated glomerular filtration rate (eGFR) ≤60 ml/min/1.73m2 from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study (47% male, 53% Black), we measured urine biomarkers of kidney tubule health at baseline: monocyte chemoattractant protein-1 [MCP-1], alpha-1-microglobulin [α1m], kidney injury molecule-1 [KIM-1], epidermal growth factor [EGF], chitinase-3-like protein 1 [YKL-40], and uromodulin [UMOD]. Cox proportional hazards regression was used to examine the associations of urine biomarkers with all-cause and cause-specific mortality in nested models adjusted for urine creatinine, demographics, mortality risk factors, eGFR, and urine albumin. Results: The mean (SD) age was 70 (9.6) years and baseline eGFR was 40 (3) ml/min per 1.73m2. There were 310 deaths over a mean follow-up of 6.5 (3.2) years. In fully adjusted models, each 2-fold higher urine concentration of KIM-1 and YKL-40 were associated with all-cause mortality: hazard ratio (HR) 1.15, 95% CI 1.01,1.31 and 1.13, 95% CI 1.07,1.20, respectively. When examining cause-specific mortality, higher UMOD was associated with a lower risk of cardiovascular death (adjusted HR per 2-fold higher concentration 0.87, 95%CI 0.77,0.99), and higher MCP-1 was associated with higher risk of cancer-related death (HR per two-fold higher concentration 1.52, 95%CI 1.05,2.18). Conclusion: Among persons with diabetes and CKD, higher urine KIM-1 and YKL-40 were associated with a higher risk of all-cause mortality independently of established risk factors. Urine UMOD and MCP-1 were associated with cardiovascular- and cancer-related death, respectively.

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Section: Discussionmentioning

confidence: 99%

Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus

et al. 2023

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“…Inhibidor tisular de metaloproteinasas-2 (TIMP-2) y su proteína de unión al factor de crecimiento de insulina 7 (IGFBP7), interleucina (IL 18) son opciones de biomarcadores para predecir lesión renal aguda en la unidad de cuidados intensivos (15)(16)(17).…”

Section: Introductionunclassified

Lesión Renal Aguda y Cuidados Críticos: Avances en la Detección Temprana.

Acosta¹,

Vásquez²,

Gómez³

et al. 2023

MedicienciasUTA

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Introducción: La lesión Renal Aguda, se define como un brusco deterioro del filtrado glomerular, en horas o días, que se manifiesta por un aumento en la sangre de nitrogenados como urea y creatinina. Es una complicación frecuente en Unidad de Cuidados Intensivos, su predicción temprana es urgente y es un gran desafío diagnóstico. Objetivos: Realizar una revisión de la literatura sobre lesión renal aguda y cuidados críticos: avances en la detección temprana. Materiales y Métodos: Se realizó una revisión sistémica, se seleccionaron 42 artículos de los últimos 5 años en su gran mayoría con, casos clínicos, estudios de revisión, metaanálisis, revisión sistemática, guías, estudios observacionales, descriptivos, retrospectivos sobre el tema: lesión renal aguda y cuidados críticos: avances en la detección temprana. Resultados: La lesión renal aguda en cuidados críticos, está asociada con malos resultados a corto y largo plazo, por lo que, su detección precoz es algo primordial, no obstante, el 10 % al 30 % de los sobrevivientes de LRA, aún pueden necesitar diálisis después del alta hospitalaria. Conclusiones: La predicción temprana de lesión renal aguda con biomarcadores, estudios de ecografía renal y desarrollo de modelos de nomogramas, representan una alternativa para pacientes con riesgo elevado de desarrollar lesión renal aguda y que pueden ser diagnosticados tempranamente.

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Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

Kourtidou

Stangou

Marinaki

et al. 2021

IJMS

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Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors.

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Diagnostic performance of kidney injury molecule‐1 for detection of abnormal urinary albumin‐to‐creatinine ratio in type 2 diabetes mellitus

Cited by 3 publications

References 16 publications

Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus

Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus

Lesión Renal Aguda y Cuidados Críticos: Avances en la Detección Temprana.

Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

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