Diagnostic Performance of High-Sensitive Troponin T in Patients With Renal Insufficiency

Pfortmueller, Carmen A.; Funk, Georg‐Christian; Marti, Grischa; Leichtle, Alexander Benedikt; Fiedler, Georg Martin; Schwarz, Christoph; Exadaktylos, Aristomenis K.; Lindner, Gregor

doi:10.1016/j.amjcard.2013.08.028

Cited by 56 publications

(36 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, Pfortmueller et al [18] conducted a similar study, and found that the AUC for patients with moderate to severe renal insufficiency was 0.535, and the diagnostic accuracy of a baseline measurement of high-sensitivity troponin in patients with renal insufficiency was poor. In our study, we raised the threshold of serum hs-cTnT concentration, determined by ROC, according to both eGFR cys and eGFR creat.…”

Section: Discussionmentioning

confidence: 86%

Diagnosis of acute myocardial infarction in patients with renal insufficiency using high-sensitivity troponin T

Huang

Zhu

Wang

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 86%

Diagnosis of acute myocardial infarction in patients with renal insufficiency using high-sensitivity troponin T

Huang

Zhu

Wang

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…Troponin elevation is common in patients with renal disease [21]. Increased pulmonary pressure may reflect valvular regurgitation and heart failure.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of serum troponin levels to predict 1-year survival rates in infective endocarditis

İpek¹,

Güray²,

Acar³

et al. 2015

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Lippi and Cervellin compared the effect of decreasing glomerular filtration rate on plasma levels of cTnI and cTnT and found a severalfold higher effect on the cTnT levels when compared to cTnI [21]. This effect is undoubtedly at least partly responsible for suboptimal diagnostic performance of the hsTnT assay in patients with impaired kidney function [22]. Still, once the cut-off values are adjusted, the hsTnT assay retains solid predictive value in the stable dialysis population [23].…”

Section: Structure and Function Of Cardiac Troponinsmentioning

confidence: 99%

High sensitivity cardiac troponin assays in the clinical laboratories

Jarolím

2015

Clinical Chemistry and Laboratory Medicine (CCLM)

117

View full text Add to dashboard Cite

Abstract:Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction. While most contemporary assays provide adequate diagnostic performance, the increased sensitivity and precision of the new, high sensitivity assays that have already been introduced into clinical practice, provide the potential to further shorten intervals between blood draws or the time needed to detect the first significant troponin elevation. In addition to the relatively modest benefits at the diagnostic end, the high sensitivity assays and the investigational ultrasensitive cardiac troponin assays offer improvements for predicting major adverse cardiovascular events, development of heart failure or transition to end-stage kidney disease. These novel high sensitivity assays can measure troponin concentrations in 50%-100% of healthy individuals and therefore allow for the distribution of troponin values within a healthy cohort to be measured, patient's baseline troponin levels to be monitored, and clinicians to be alerted of deteriorating cardiorenal conditions. We envisage that the high sensitivity assays will become important tools for predicting each patient's risk of future adverse events and for guiding and monitoring corresponding adjustments of preventative therapeutic interventions.

show abstract

Diagnostic Performance of High-Sensitive Troponin T in Patients With Renal Insufficiency

Cited by 56 publications

References 12 publications

Diagnosis of acute myocardial infarction in patients with renal insufficiency using high-sensitivity troponin T

Diagnosis of acute myocardial infarction in patients with renal insufficiency using high-sensitivity troponin T

The usefulness of serum troponin levels to predict 1-year survival rates in infective endocarditis

High sensitivity cardiac troponin assays in the clinical laboratories

Contact Info

Product

Resources

About