Diagnostic Performance of Endoscopic Ultrasound (EUS) for Non-Calcific Chronic Pancreatitis (NCCP) Based on Histopathology

Trikudanathan, Guru; Vega-Peralta, Jose; Malli, Ahmad; Munigala, Satish; Han, Yusheng; Bellin, Melena D.; Barlass, Usman; Chinnakotla, Srinath; Dunn, Ty B.; Pruett, Timothy L.; Beilman, Greg J.; Arain, Mustafa A.; Amateau, Stuart K.; Mallery, Shawn; Freeman, Martin L.; Attam, Rajeev

doi:10.1038/ajg.2016.48

Cited by 42 publications

(28 citation statements)

References 30 publications

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“…One study showed EUS has good efficacy in diagnosing early non-calcific CP with sensitivity and specificity of 90.5 and 85.7%, respectively, when compared to histopathology using at least four EUS criteria [87]. However, in another study examining patients with abdominal pain and non-calcific CP requiring total pancreatectomy and islet auto-transplantation, sensitivity of 61% was found [90]. Another caveat is that both EUS findings of CP as well as histopathologic features of CP are found in several conditions without symptomatic clinical presentations.…”

Section: Diagnosis Of Chronic Pancreatitismentioning

confidence: 99%

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

2017

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This paper reviews the current status of our understanding of the epidemiology, diagnosis, and management of the continuum of pancreatic diseases from acute and recurrent acute pancreatitis to chronic pancreatitis and the diseases that are often linked with pancreatitis including diabetes mellitus and pancreatic cancer. In addition to reviewing the current state of the field, we identify gaps in knowledge that are necessary to address to improve patient outcomes in these conditions.

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Section: Diagnosis Of Chronic Pancreatitismentioning

confidence: 99%

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

2017

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“…Endoscopic ultrasonography (EUS), which can evaluate the pancreatic parenchyma at high resolution, has been used to assess the severity of CP by evaluating the number of characteristic EUS features, using the Rosemont classification (RC), which was proposed in 2009 to identify consensus‐based EUS criteria for the diagnosis of CP, or Japan Pancreas Society clinical diagnostic criteria 2009 (JPS criteria) . EUS‐based diagnosis of CP is widely used at clinical sites, but it has several limitations including low reproducibility, the subjective criteria of diagnosing these EUS features, and the difficulty of correlating these EUS features with histological features of CP …”

Section: Introductionmentioning

confidence: 99%

Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis

Kuwahara

Hirooka

Kawashima

et al. 2018

J of Gastro and Hepatol

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“…Using ≥4 EUS features provided the best balance of sensitivity (61%) and specificity (75%) for predicting a FS ≥ 2. (26) This study suggests that current EUS criteria are not adequate to diagnose non-calcific CP. Another question from this study is whether current selection criteria for TPIAT are adequate.…”

Section: Imaging Update: Endoscopic Ultrasound (Eus)mentioning

confidence: 78%

Clinical chronic pancreatitis

Park¹

2016

Current Opinion in Gastroenterology

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Purpose of Review To summarize observations in clinical chronic pancreatitis (CP) in the past year. Recent Findings A predisposing genetic mutation was identified in 67% of cases of pediatric chronic pancreatitis. A novel susceptibility gene involving a hybrid allele (CEL-HYB) is associated with idiopathic CP. ABO blood type B and FUT2 non-secretor status is associated with asymptomatic hyperlipasemia and chronic pancreatitis. Alcohol consumption impairs CFTR activity leading to decreased bicarbonate secretion and patients with susceptible CFTR mutations can develop clinical pancreatitis. CT imaging findings in CP correlate poorly with pain patterns. EUS features correlate poorly with fibrosis. Circulating epithelial cells are present in CP patients but not healthy volunteers. Surgery is superior to endoscopic treatment in providing durable pain relief (> 5 years). Repetitive pancreatic duct stent placements and chronic narcotic use are pre-operative predictors of poor outcome after total pancreatectomy with islet cell auto transplantation (TPIAT). Summary Novel genetic mutations for idiopathic chronic pancreatitis are being identified. Alcohol impairs CFTR activity and may explain a mechanism for pancreatitis. Current imaging modalities correlate poorly with clinical pain presentation and fibrosis in CP. Novel imaging modalities are needed. As TPIAT grows, rigorous outcomes analysis is needed to drive patient selection.

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Diagnostic Performance of Endoscopic Ultrasound (EUS) for Non-Calcific Chronic Pancreatitis (NCCP) Based on Histopathology

Abstract: Correlation between standard EUS features and histopathology is poor in NCCP. MPD irregularity is an independent predictor for NCCP.

Cited by 42 publications

References 30 publications

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis

Clinical chronic pancreatitis

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