Diagnostic performance of diffusion tensor imaging parameters in breast cancer and correlation with the prognostic factors

Abstract

1 J. Magn. Reson. Imaging 2017;45:660-672.

Multiparametric MRI of the breast: A review

“…Furthermore, published evidence has shown how DTI can discriminate between malignant and benign lesions and even be a prognostic factor due to its correlation with specific molecular breast cancer subtypes, such as ER and Ki-67. 71 Proton MR Spectroscopy 1 H-MRS is a noninvasive technique that depicts the chemical composition of a certain tissue by providing spatially localized signal spectra in which spectral peaks reflect the structure and concentration of different chemical compounds in the region of interest. The MRI signal spectra provide details about the various levels of associated detectable metabolites and, thus, MRS can recognize different tissue conditions, such as normal, benign, malignant, necrotic, or hypoxic.…”

“…This has also been recently supported by Plaza et al, who also found that the degree of background parenchymal enhancement in normal breast tissue can influence, yet is completely independent from, fibroglandular tissue. Furthermore, published evidence has shown how DTI can discriminate between malignant and benign lesions and even be a prognostic factor due to its correlation with specific molecular breast cancer subtypes, such as ER and Ki‐67 …”

Diffusion tensor imaging parameters in testes with nonobstructive azoospermia

“…14,15 DTI has been reported to provide satisfactory characterization of tissue microstructure and pathophysiology, originally in the central nervous system, and later in many applications, including myocardium, prostate, kidneys, liver, and breast. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Information obtained from DTI contains not only the amount of diffusion but also the anisotropy of diffusion, which is quantified by the fractional anisotropy (FA). [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] In a previous study, the ADC and FA of normal adult testis was measured and the value of DTI in the characterization of various testicular lesions was assessed.…”

Application of in vivo MR methods in the study of breast cancer metabolism

“…Furthermore, higher radial diffusivity and lower FA, relative anisotropy and geodesic anisotropy values were observed in ER− breast cancer. Ki‐67 showed significant negative correlation with FA, relative anisotropy and geodesic anisotropy …”