Diagnostic performance of contrast-enhanced CT-scan in sinusoidal obstruction syndrome induced by chemotherapy of colorectal liver metastases: Radio-pathological correlation

Cayet, Sophie; Pasco, Jeremy; Dujardin, Fanny; Besson, Marie; Orain, Isabelle; Muret, A. De; Miquelestorena-Standley, Élodie; Thiery, Julien; Genet, Thibaud; Bayon, Anne-Gwenn Le

doi:10.1016/j.ejrad.2017.06.025

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…Several studies have demonstrated early diagnosis or prediction of VOD/SOS with this method, before the appearance of conventional clinical criteria [74][75][76]. Other proposed methods involve the multifactorial, or panel, scoring approach for early diagnosis or prediction of VOD/SOS with the use of ultrasound [77][78][79][80]. Independent predictors of VOD/SOS that may enhance ultrasound diagnosis include gallbladder wall thickening and paraumbilical vein blood flow [78,80].…”

Section: New Diagnostic Techniques/parametersmentioning

confidence: 99%

“…Proposed methods aimed at diagnosis or prediction specifically of chemotherapy-induced VOD/SOS include a score consisting of expression of CD34 cells, increased levels of smooth muscle actin, and aberrant expression of glutamine synthetase [79]. The use of contrast-enhanced computed tomography also has been suggested to detect multiple factors such as clover-like sign, peripheral distribution of heterogeneity, increased spleen volume, and hepatic parenchyma, which were found to be independent predictors of VOD/SOS via this method [77,81,82].…”

Section: New Diagnostic Techniques/parametersmentioning

confidence: 99%

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Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Corbacioglu

Jabbour

Mohty

2019

Biology of Blood and Marrow Transplantation

129

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A B S T R A C T Veno-occlusive disease, also known as sinusoidal obstruction syndrome (VOD/SOS), is a potentially life-threatening complication of allogeneic or autologous hematopoietic stem cell transplantation (HSCT) most commonly associated with high-intensity chemotherapies. The development of VOD/SOS may be rapid and unpredictable, and the importance of identifying risk factors to facilitate prompt diagnosis and timely treatment has become increasingly recognized. The reporting of new retrospective study data for adults and children and the emergence of novel anticancer therapies that may increase the risk of VOD/SOD also necessitate updates on risk factors, as provided in this review. The latest studies reporting VOD/SOS risk factors support previously published data, although the importance of patient-related factors, such as acute kidney injury, increased international normalized ratio, female sex (in children), and platelet refractoriness, is given greater emphasis in the recent data. Nontransplantation-related chemotherapies associated with increased risk for VOD/SOS include oxaliplatin and 5-fluorouracil chemotherapies. The novel antibody drug conjugates gemtuzumab ozogamicin and inotuzumab ozogamicin are now reported in product labeling to pose risks for VOD/SOS based on clinical trial data; an expert consensus panel has issued recommendations for risk reduction measures with inotuzumab ozogamicin treatment, including VOD/SOS prophylaxis and limitation to 2 inotuzumab ozogamicin treatment cycles. A wide range of biomarkers, including genetic, hematologic, hepatic, and inflammatory factors, as well as novel diagnostic techniques such as thromboelastography and measures of liver stiffness, may further enhance future risk calculation for VOD/SOS, although none has been widely adopted. Continual monitoring for and recognition of VOD/SOS risk factors are essential for optimal management of this complication.

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Section: New Diagnostic Techniques/parametersmentioning

confidence: 99%

Section: New Diagnostic Techniques/parametersmentioning

confidence: 99%

Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Corbacioglu

Jabbour

Mohty

2019

Biology of Blood and Marrow Transplantation

129

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“…Zhou et al reported that liver parenchyma surrounding the main hepatic veins demonstrated relatively normal enhancement compared to the rest of the patchy enhanced area of liver. This interesting nding is called "clover sign", suggest that the venules adjacent to the hepatic main vein are more likely to keep patent; the extent of abnormal patchy liver enhancement re ect the severity of the disease [20][21][22][23][24] . In present study, the SOS images showed that the enhancement distribution around the main hepatic vein was obvious, while the patchy enhancement was dominant in the BCS patients, which was related to the different pathogenesis, location and degree of liver parenchymal injury of the two diseases.…”

Section: Discussionmentioning

confidence: 99%

Imaging findings and differential diagnosis of hepatic sinusoidal occlusion syndrome and Budd-Chiari syndrome

Jia

Zhao

Feng

et al. 2021

Preprint

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Objective To retrospectively analyze the clinical and imaging manifestations differential points between hepatic sinusoidal obstruction syndrome (SOS) and Budd-Chiari syndrome (BCS). Material The clinical symptoms, laboratory examination and imaging findings of 15 cases of hepatic sinusoidal obstruction syndrome and 33 cases of Budd-Chiari syndrome were statistically analyzed, find the identification points. The study used the Fisher test, P values of 0.05 or less were considered to indicate significant differences. The retrospective study was approved by the hospital's ethics committee. Results Laboratory tests: There were significant differences in total protein reduction rate (66.7% vs 9.1%, p༜0.01), albumin reduction rate (66.7% vs 9.1%, p༜0.01), Gamma-glutamyltransferase elevation rate (100% vs 6.1%, P༜0.01), alkaline phosphatase elevation rate (60% vs 6.1%, p༜0.01), and abnormal rate of prothrombin time (100% vs 21.2%, p༜0.01) between the two groups (BCS vs SOS). It also indicates that the liver function of SOS patients is more seriously impaired. Image findings: The following image findings were observed significant more frequently in SOS than in BCS and were statistically significant: gallbladder wall thickening (66.7% vs 78.2%, p༜0.01), ascites (80% vs 27.3%, p༜0.01), cloverleaf or claw-like shapes (80% vs 0%, p༜0.01). The following images appeared more frequently in BCS than in BCS and were statistically significant: caudate lobe enlargement (33.3% vs 75.8%, p༜0.01), collateral circulation (46.7% vs 93.9%, p༜0.01), diffuse patchy enhancement (20% vs 93.9%, p༜0.01), homogeneous in delayed phase (13.3% vs 90.1%, p༜0.01). Conclusion To Identification of SOS and BCS should be based on the patient's laboratory examination and imaging findings to improve diagnostic accuracy.

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“…In one study, orthotopic ovarian-mouse models revealed tumor-derived, interleukin-6-stimulated, hepaticthrombopoietin (TPO) synthesis and paraneoplastic induction of thrombocytosis (255). Liver metastasis along with Fusobacterium in the liver can also trigger the thrombotic Trousseau's syndrome (256)(257)(258). Observed abnormalities associated with coagulation factors like fibrinogen and prothrombin in liver disease could activate platelets (259).…”

Section: Platelet Activation and Aggregationmentioning

confidence: 99%

The Provocative Roles of Platelets in Liver Disease and Cancer

et al. 2021

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Both platelets and the liver play important roles in the processes of coagulation and innate immunity. Platelet responses at the site of an injury are rapid; their immediate activation and structural changes minimize the loss of blood. The majority of coagulation proteins are produced by the liver—a multifunctional organ that also plays a critical role in many processes: removal of toxins and metabolism of fats, proteins, carbohydrates, and drugs. Chronic inflammation, trauma, or other causes of irreversible damage to the liver can dysregulate these pathways leading to organ and systemic abnormalities. In some cases, platelet-to-lymphocyte ratios can also be a predictor of disease outcome. An example is cirrhosis, which increases the risk of bleeding and prothrombotic events followed by activation of platelets. Along with a triggered coagulation cascade, the platelets increase the risk of pro-thrombotic events and contribute to cancer progression and metastasis. This progression and the resulting tissue destruction is physiologically comparable to a persistent, chronic wound. Various cancers, including colorectal cancer, have been associated with increased thrombocytosis, platelet activation, platelet-storage granule release, and thrombosis; anti-platelet agents can reduce cancer risk and progression. However, in cancer patients with pre-existing liver disease who are undergoing chemotherapy, the risk of thrombotic events becomes challenging to manage due to their inherent risk for bleeding. Chemotherapy, also known to induce damage to the liver, further increases the frequency of thrombotic events. Depending on individual patient risks, these factors acting together can disrupt the fragile balance between pro- and anti-coagulant processes, heightening liver thrombogenesis, and possibly providing a niche for circulating tumor cells to adhere to—thus promoting both liver metastasis and cancer-cell survival following treatment (that is, with minimal residual disease in the liver).

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Diagnostic performance of contrast-enhanced CT-scan in sinusoidal obstruction syndrome induced by chemotherapy of colorectal liver metastases: Radio-pathological correlation

Cited by 28 publications

References 27 publications

Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Imaging findings and differential diagnosis of hepatic sinusoidal occlusion syndrome and Budd-Chiari syndrome

The Provocative Roles of Platelets in Liver Disease and Cancer

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