Diagnostic Performance of an Electronic Nose, Fractional Exhaled Nitric Oxide, and Lung Function Testing in Asthma

Montuschi, Paolo; Santonico, Marco; Mondino, Chiara; Pennazza, Giorgio; Mantini, G.; Martinelli, Eugenio; Capuano, Rosamaria; Ciabattoni, Giovanni; Paolesse, Roberto; Natale, Corrado Di; Barnes, Peter J.; D’Amico, A.

doi:10.1378/chest.09-1836

Cited by 176 publications

(116 citation statements)

References 20 publications

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“…It would be worth testing this approach using other non-invasive techniques for assessing airway inflammation including measurement of markers of oxidative stress, such as 8-isoprostane (28), in exhaled breath condensate (EBC) (29), and e-nose (30). Further studies are required to clarify whether a strategy for asthma control based on inflammatory parameters could also be applied to therapeutic regimens with leukotriene receptor antagonists (31) should also be investigated.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Adjustment of Stable Asthma Treatment with Fractional Exhaled Nitric Oxide and Sputum Eosinophils

et al. 2012

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Current approaches to control asthma do not involve direct assessment of airway inflammation. The aim of this study is to assess whether the therapeutic adjustments of steroid treatment according to a stepwise algorithm based on sputum Eosinophils (sEos) and fractioned exhaled Nitric Oxide (FeNO) were effective in maintaining the stability of a group of stable asthmatic patients during a twelvemonth follow-up. Fourteen asthmatic patients, treated for asthma according to a previously published protocol, were enrolled in the study. The patients underwent clinical evaluation, pulmonary function tests, measuring of airway hyperresponsiveness to methacholine, and determination of FeNO and sEos at visit 1. These procedures were repeated after 6 and 12 months (Visits 2 and 3, respectively). Symptoms score gradually improved during the study (p=O.008 ), no changes were observed in the frequency of clinical asthma exacerbations or in airway hyperresponsiveness to methacholine. At the end of the study both sEos and FeNO were significantly improved (p=O.Oll and p=O.003, respectively) and at visit 3 the median steroid dose was reduced (p=O.039) in accordance with the improving of symptoms score, FeNO and sEos values. A direct relationship was observed between the difference of FeNO values and the difference ofsEos registered between visits 1 and 2 (r 2=609, p

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Section: Discussionmentioning

confidence: 99%

Long-Term Adjustment of Stable Asthma Treatment with Fractional Exhaled Nitric Oxide and Sputum Eosinophils

et al. 2012

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“…Biomarkers of oxidative stress and airway inflammation including 8-isoprostane [30] and leukotriene B4 [31] have also been measured in exhaled breath condensate, a non-invasive method for sampling airway secretions [32], in healthy smokers and patients with COPD. Furthermore, electronic nose is a promising non-invasive technique for assessment of airway inflammation [33]. SLPI and elafin are elastase inhibitors that seem to play an important role in protease-antiprotease balance and in controlling elastase levels.…”

Section: Discussionmentioning

confidence: 99%

Sputum And Nasal Lavage Lung-Specific Biomarkers Before And After Smoking Cessation

Tsiligianni¹,

Bouloukaki²,

Tsoumakidou³

et al. 2011

C38. Airway Inflammation: From Mechanisms to Non-Invasive Biomarkers

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Background: Little is known about the effect of smoking cessation on airway inflammation. Secretory Leukocyte Protease Inhibitor (SLPI), Clara Cell protein 16 (CC16), elafin and human defensin beta-2 (HBD-2) protect human airways against inflammation and oxidative stress. In this longitudinal study we aimed to investigate changes in sputum and nasal lavage SLPI, CC16, elafin and HBD-2 levels in healthy smokers after 6 and 12 months of smoking cessation. Methods: Induced sputum and nasal lavage was obtained from healthy current smokers (n = 76) before smoking cessation, after 6 months of smoking cessation (n = 29), after 1 year of smoking cessation (n = 22) and from 10 healthy never smokers. SLPI, CC16, elafin and HBD-2 levels were measured in sputum and nasal lavage supernatants by commercially available ELISA kits.

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“…This holds for lung cancer patients versus controls [169][170][171][172] and versus patients with COPD [173]. Interestingly, asthmatics can also be discriminated from healthy controls and COPD patients (cross-validated accuracy 80-100%) [163,164,174]. In addition, eNoses are an attractive screening method for infectious diseases [175,176].…”

Section: Electronic Nose: Exhaled Molecular Profilesmentioning

confidence: 99%

“…Breath collection is critical for eNose assessments and includes standardization of expiratory flow, expired volume, water vapour, either or not filtering inspired air with VOC-filter and total versus late expired sampling [163,164]. The data analysis uses normalisation methods, followed by pattern recognition algorithms and classification techniques such as principal component analysis [165].…”

Section: Electronic Nose: Exhaled Molecular Profilesmentioning

confidence: 99%

Biomarkers in asthma and allergic rhinitis

Diamant

Boot

Mantzouranis

et al. 2010

Pulmonary Pharmacology & Therapeutics

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Diagnostic Performance of an Electronic Nose, Fractional Exhaled Nitric Oxide, and Lung Function Testing in Asthma

Cited by 176 publications

References 20 publications

Long-Term Adjustment of Stable Asthma Treatment with Fractional Exhaled Nitric Oxide and Sputum Eosinophils

Long-Term Adjustment of Stable Asthma Treatment with Fractional Exhaled Nitric Oxide and Sputum Eosinophils

Sputum And Nasal Lavage Lung-Specific Biomarkers Before And After Smoking Cessation

Biomarkers in asthma and allergic rhinitis

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