Diagnostic pathways and delay among tuberculosis patients in Stockholm, Sweden: a retrospective observational study

Abstract

BackgroundAsylum seekers in Sweden are offered tuberculosis (TB) screening at a voluntary post-arrival health examination. The role of this screening in improving the TB diagnostic pathway has not been previously evaluated. The aim of this study was to determine diagnostic pathways for active TB cases and compare diagnostic delays between different pathways.MethodsRetrospective review of medical records of patients reported with active TB in Stockholm in 2015, using a structured and pre-coded form.ResultsSeventy-one percent of patients actively sought health care due to symptoms. As for source of referral to TB specialist clinic, 15% came from screening of eligible migrants, of whom the majority were asymptomatic. Among asylum seekers, 69% were identified through screening at a health examination (HE). The main sources of referral to TB clinics were emergency departments (27%) and primary health care centers (20%). Median health care provider delay was significantly longer in patients identified through migrant screening in health examination.ConclusionsScreening at a health examination was the main pathway of active TB detection among mainly asymptomatic and non-contagious asylum seekers but contributed modestly to total overall TB case detection. In these patients TB was diagnosed early in a non-contagious phase of the disease. Further research is required to assess the effectiveness and cost-effectiveness of HE TB screening as well as inclusion of other groups of migrants from high incidence countries in the screening program in terms of impact on delay, transmission and treatment outcomes.Electronic supplementary materialThe online version of this article (10.1186/s12889-019-6462-5) contains supplementary material, which is available to authorized users.

Estimating tuberculosis drug resistance amplification rates in high-burden settings

“…Accounting appropriately for DR-TB in mathematical models of disease is critical, as it differs considerably from drug-sensitive TB (DS-TB) in both epidemiological parameters and relevant outcomes. Some variation in disease characteristics is relatively well-understood, including the prolonged treatment duration [ 7 ], adverse event rates [ 8 ] and diagnostic pathway performance [ 9 , 10 ]. However, considerable uncertainties persist regarding important characteristics of MDR-TB, including pathogen’s fitness, transmissibility and risk of resistance amplification related to treatment [ 11 , 12 ].…”

Improving the detection of infectious diseases in at-risk migrants with an innovative integrated multi-infection screening digital decision support tool (IS-MiHealth) in primary care: A pilot cluster-randomized controlled trial

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Modelling tuberculosis drug resistance amplification rates in high-burden settings

“…Accounting appropriately for MDR-TB in mathematical models of disease is critical; as it differs considerably from drug-sensitive TB (DS-TB) in both epidemiological parameters and relevant outcomes. Some variation in parameters is relatively well-understood, including the prolonged treatment duration [7], adverse event rates [8] and diagnostic pathway performance [9,10]. However, considerable uncertainties persist with regards important characteristics of MDR-TB, particularly those relating to fitness, transmissibility and risk of resistance amplification related to treatment [11,12].…”