Diagnostic outcomes of bone marrow aspirate and trephine biopsies performed at a hospital in KwaZulu-Natal, South Africa

Tshabalala, Wanda S; Pillay, S; Wilson, Douglas P.

doi:10.4102/ajlm.v9i1.1028

Cited by 2 publications

(2 citation statements)

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“…In another study, the most prevalent malignant diagnoses, listed in descending order of frequency, were as follows: leukemia (20%), multiple myeloma (13%), and lymphoma (11%). Notably, acute leukemia constituted a significant portion, accounting for 46% (11 out of 24 cases) of all diagnosed leukemia cases when compared to chronic leukemia [13]. Our own findings echoed this trend, revealing a higher prevalence of acute leukemia cases in contrast to chronic leukemias and lymphomas.…”

Section: Discussionsupporting

confidence: 79%

Hematological disorders on bone marrow examination in a tertiary care Centre

Bilal,

Ali,

Kiani

2024

Pak J Pathol

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Objective: The aims of this study were to understand the range of different blood-related disorders diagnosed through bone marrow examination and to explore the connection between the age groups and genders of our patients with the subtypes of acute leukemia. Material and Methods: This was a cross-sectional study carried over a period of one year from January 2022 to December 2022, in the department of Pathology, Pakistan Institute of Medical Sciences (PIMS), Islamabad. Analysis of bone marrow was conducted on patients referred with suspected blood-related disorders, and a total of 254 cases were incorporated into the study. We divided age into groups as 0-12 years (paediatric age group) and >12 years (adults) for comparison with subtypes of acute leukemias. Pearson chi-square test was applied. P value of <0.05 was considered statistically significant. Results: The age range was from 05 months - 91 years with male: female ratio of 1.2:1. The prevalent non-malignant conditions identified during bone marrow examination were peripheral destruction/consumption of platelets (24.8%) followed by anemias (22%) and infection- related changes (9.4%). Among hematological malignancies, acute leukemias were the most frequent (22.8%), with chronic leukemias following at 7.1%. We also observed that Acute Lymphoblastic Leukemia was more common in Paediatric age group, while Acute Myeloid Leukemia was more frequent type of acute leukemia in adults (p <0.001). Conclusion: The examination of bone marrow specimens is a key procedure for swiftly obtaining a confirmatory diagnosis for numerous hematological disorders, including hematologic malignancies. Keywords: Anemia, Bone Marrow Trephine Biopsy, Bone marrow aspiration, Leukemia, Megaloblastic anemia

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Section: Discussionsupporting

confidence: 79%

Hematological disorders on bone marrow examination in a tertiary care Centre

Bilal,

Ali,

Kiani

2024

Pak J Pathol

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“… 16 In addition, circulating monocytes correlate with the well-known prognostic factors for MM, and evaluating monocyte subpopulations can enhance our understanding of MM mechanisms and aid patient follow-up. Although bone marrow aspirates and trephine biopsies provide high diagnostic yields for MM detection, 17 finding a less invasive diagnostic procedure such as flow cytometry will be a clinical breakthrough.…”

Section: Introductionmentioning

confidence: 99%

Higher proportion of non-classical and intermediate monocytes in newly diagnosed multiple myeloma patients in Egypt: A possible prognostic marker

Zahran

Nafady-Hego

Moeen

et al. 2021

African Journal of Laboratory Medicine

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Background: Interaction between multiple myeloma (MM) cells and proximal monocytes is expected during plasma cell proliferation. However, the role of monocyte subsets in the disease progression is unknown.Objective: This study evaluated circulating monocyte populations in MM patients and their correlation with disease severity.Methods: Peripheral monocytes from 20 patients with MM attending Assiut University Hospital in Assiut, Egypt, between October 2018 and August 2019 were processed using a flow cytometry procedure and stratified using the intensity of expression of CD14 and CD16 into classical (CD16−CD14++), intermediate (CD16+CD14++), and non-classical (CD16++CD14+) subsets. The data were compared with data from 20 healthy control participants with comparable age and sex.Results: In patients with MM, the percentage of classical monocytes was significantly lower (mean ± standard error: 77.24 ± 0.66 vs 83.75 ± 0.5), while those of non-classical (12.44 ± 0.5 vs 8.9 ± 0.34) and intermediate (10.3 ± 0.24 vs 7.4 ± 0.29) monocytes were significantly higher when compared with those of controls (all p 0.0001). Proportions of non-classical and intermediate monocytes correlated positively with serum levels of plasma cells, M-protein, calcium, creatinine and lactate dehydrogenase, and correlated negatively with the serum albumin level. Proportions of classical monocytes correlated positively with albumin level and negatively correlated with serum levels of M-protein, plasma cells, calcium, creatinine, and lactate dehydrogenase.Conclusion: Circulating monocyte subpopulations are skewed towards non-classical and intermediate monocytes in MM patients, and the intensity of this skewness increases with disease severity.

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Diagnostic outcomes of bone marrow aspirate and trephine biopsies performed at a hospital in KwaZulu-Natal, South Africa

Cited by 2 publications

References 19 publications

Hematological disorders on bone marrow examination in a tertiary care Centre

Hematological disorders on bone marrow examination in a tertiary care Centre

Higher proportion of non-classical and intermediate monocytes in newly diagnosed multiple myeloma patients in Egypt: A possible prognostic marker

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