Diagnostic Modalities in Choroidal Melanoma

Char, Devron H.; Stone, Robert D.; Irvine, Alexander R.; Crawford, J. Brooks; Hilton, George F.; Lonn, Lawrence I.; Schwartz, Ariah

doi:10.1016/0002-9394(80)90115-4

Cited by 121 publications

(58 citation statements)

References 17 publications

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“…At present, the clinical differentiation of small benign choroidal naevi from small choroidal melanomas is mainly based on fluorescein angiography, the efficacy of which, however, seems to be limited in small choroidal pigmented tumours [2], Fluorescein angiography, in principle, can dis tinguish two conditions only: naevus and melanoma. Ex perimental evidence, however, suggests that a spectrum of a typical melanocytic proliferations separates benign naevi from melanomas [4], In melanocytic tumours of the skin, it could recently be shown that the native fluorescence of naevi is different from that of melanomas [7], In this prelim inary investigation we, therefore, studied the endogenous fluorescence of the normal sclera, choroid, and RPE as well as the endogenous fluorescence of tissue with choroidal melanoma in vitro.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Fluorescence of Ocular Malignant Melanomas

Lohmann

Wiegand²,

Stolwijk³

et al. 1995

Ophthalmologica

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The endogenous fluorescence of human choroid, sclera, and retinal pigment epithelium (RPE) in normal tissue and tissue with uveal melanoma was studied in vitro by a non-invasive and non-destructive fluorescence technique which had previously been applied for the diagnostic evaluation of pigmented lesions of the skin. The fluorescence of the normal choroid is rather dark, the normal sclera exhibits blue fluorescence and the RPE bright yellow fluorescence due to deposits of lipofuscin. In choroidal melanoma, the lipofuscin granulae at the level of the retinal pigment epithelium are cleaved off above the tumour and broken up into small remnants. The fluorescence intensity emitted from the tumour is rather low which agrees with previous findings on skin melanomas. The results may become interesting for diagnostic evaluation of uveal melanomas, uveal naevi, and pigmented conjunctival tumours by endogenous fluorescence.

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Section: Discussionmentioning

confidence: 99%

Endogenous Fluorescence of Ocular Malignant Melanomas

Lohmann

Wiegand²,

Stolwijk³

et al. 1995

Ophthalmologica

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“…The increased leakage was also interpreted by other investigators as the expression of damage to the vascular endothelium [1], which then results in the development of micro-aneurysms and ultimately leads to vessel obliteration. These radiation effects are also detected in conjunction with other types of radiation such as ruthenium [1,3,7,13,15,18] or iodine brachytherapy [15]. A summary is presented in Table 1.…”

Section: Discussionmentioning

confidence: 96%

Indocyanine green angiography and fluorescein angiography of malignant choroidal melanomas following proton beam irradiation

Krause

Bechrakis

Heinrich

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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“…5A). 4,7,8 There may be vascular pulsations in a highly vascularized tumor. 9 A mushroom-like configuration, indicating that the tumor has broken through Bruch's membrane, is almost pathognomonic of choroidal melanoma (Fig.…”

Section: A/b Scan Ultrasonographymentioning

confidence: 98%

“…Fluorescein angiography has limited use in the diagnosis of choroidal melanoma. 4 However, fluorescein angiography can be useful in differentiating other simulating lesions such as choroidal hemangioma, disciform lesion, choroidal detachment, and hemorrhagic lesions.…”

Section: Fluorescein Angiographymentioning

confidence: 99%