Diagnostic localization of extra-adrenal pheochromocytoma: Comparison of 123I-MIBG imaging and 131I-MIBG imaging

Nakatani, Tatsuya; Hayama, Takuma; Uchida, Junji; Nakamura, Kenji; Takemoto, Yoshiaki; Sugimura, Kazunobu

doi:10.3892/or.9.6.1225

Cited by 15 publications

(15 citation statements)

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“…15,16 Paragangliomas of the urinary bladder account for less than 0.5% of bladder tumors. Primary paragangliomas of the bladder, which have also been incorrectly designated in the literature as bladder pheochromocytomas, have a female to male ratio of 3:2, with an average age diagnosis of 41 years.…”

Section: Discussionmentioning

confidence: 99%

GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma

Epstein

2013

Modern Pathology

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GATA3 is a zinc-finger transcription factor, which is expressed in various normal and neoplastic tissues. Amongst tumors, it labels urothelial carcinoma, collecting duct carcinoma of the kidney, breast carcinoma, lymphoma and, uncommonly, endometrial carcinoma. Few studies have investigated its positivity in various neoplasms that may mimic urothelial neoplasms. In this study, we evaluated GATA3 expression in urinary bladder paragangliomas, which may closely mimic urothelial carcinomas. We retrieved 12 cases of paragangliomas from the urinary bladder and 20 cases of paragangliomas from non-urologic sites using the Hopkins Pathology Data Base system. GATA3 was positive in 10 of the 12 (83%) urinary bladder paragangliomas studied on routine slide sections. Most (6/12) of the staining was diffusely strong (3 þ ) staining, whereas the rest (4/12) that were positive showed mixed intensities (strong 3 þ to moderate 2 þ ). The 20 paragangliomas from other sites were constructed into tissue microarrays, wherein three cores from each tumor were taken. Fifteen out of 20 (75%) paragangliomas outside of the bladder were positive for GATA3 staining. Moderate (2 þ ) or strong (3 þ ) staining was seen in 13/20 (65%) of extravesical paragangliomas, ranging from 5 to 100% of the cell labeling (mean 59%, median 60%). In the remaining 7/20 (35%) cases, only weak (2/7) or negative (5/7) immunoreactivity for GATA3 was seen. An additional 15 cases of metastatic paraganglioma from various primary sites were retrieved with 12 of 15 (80%) metastatic paragangliomas staining positively for GATA3. Overall, for paragangliomas, regardless of site, 78.7% were positive for GATA3. Recognition of this finding will aid pathologists in preventing a misdiagnosis of a urothelial tumor based on GATA3 expression, which is critical given the differences in treatment, follow-up and prognosis between bladder paragangliomas and urothelial carcinoma.

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Section: Discussionmentioning

confidence: 99%

GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma

Epstein

2013

Modern Pathology

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“…On the other hand, 131 I-MIBG scintigraphy offers superior specificity for extra-adrenal pheochromocytoma (95-100%) (22,23). In addition, it has been reported that 123 I-MIBG scintigraphy has several potential advantages over 131 I-MIBG scintigraphy (24,25), although 123 I-MIBG scintigraphy is less commonly used than 131 I-MIBG scintigraphy in Japan. In the present case, 131 I-MIBG scintigraphy combined with CT was effective for the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Small Extra-Adrenal Pheochromocytoma Causing Severe Hypertension in an Elderly Patient

et al. 2006

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“…The uptake of radioiodinated MIBG in other neural crest cell-derived tumors, such as medullary thyroid carcinoma and carcinoid tumors, is more limited, resulting in lower sensitivity when used for these tumors. 131 I MIBG is a more stable and readily available isotope than 123 I, and has been widely used for the localization of neural crest tumors and the treatment of metastatic disease; however, 123 I is the preferred isotope for imaging because it is a pure gammaemitter with a shorter half-life and greater avidity to neural crest tumors and, therefore, can be used at a higher dosage resulting in greater sensitivity and specificity for the detection of neural crest tumors [38,39].…”

Section: Mibg Spect-ctmentioning

confidence: 99%

SPECT-CT for Tumor Imaging

et al. 2011

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Diagnostic localization of extra-adrenal pheochromocytoma: Comparison of 123I-MIBG imaging and 131I-MIBG imaging

Cited by 15 publications

References 0 publications

GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma

GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma

Small Extra-Adrenal Pheochromocytoma Causing Severe Hypertension in an Elderly Patient

SPECT-CT for Tumor Imaging

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