Diagnostic laparoscopy in radiation-induced liver disease

Silveira, Eduardo B. V. Da; Jeffers, Lennox J.; Schiff, Eugene R.

doi:10.1067/mge.2002.120879

Cited by 19 publications

(10 citation statements)

References 5 publications

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“…Damage to the hepatic venule endothelium contributes to the formation of microthrombi that cause venous obstruction, panlobular congestion, hepatocyte loss, and fibrosis mediated by transforming growth factor-β1 (TGF-β1) [15][16][17][18]. In animal studies, TGF-β1 levels increases in irradiated dose dependent and it was significantly correlated with the fibrosis [17,18].…”

Section: The Pathological Changes In Irradiated Livermentioning

confidence: 99%

Pathology and images of radiation-induced hepatitis: a review article

et al. 2018

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Recent advances in highly conformal radiotherapies greatly extend the indications for radiotherapy of liver tumors. However, because of poor tolerance to hepatic radiation, estimation of the intensity of irradiation of the liver is important, particularly for a cirrhotic liver. Knowledge of radiation-induced hepatitis is important for understanding how to optimize hepatic radiation therapy. Pathological changes of the irradiated liver, which include perivenular fibrosis, sinusoidal obstruction, and damage to Kupffer cells and hepatocytes, can be visualized using clinical imaging techniques. This review article discusses and illustrates the pathological and radiological changes of hepatic tumors and the surrounding parenchyma of the irradiated liver.

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Section: The Pathological Changes In Irradiated Livermentioning

confidence: 99%

Pathology and images of radiation-induced hepatitis: a review article

et al. 2018

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“…RILD -both classic and non-classic -is a severe condition for patients being treated by RT. Radiation to the liver induces a hepatic venoocclusive disease [14][15][16][17] (however, most often sparing the larger veins), and activation of hepatic stellate cells causes atrophy, loss of hepatocytes and formation of fibrosis. This is a life threatening condition, which can progress to liver failure.…”

Section: Discussionmentioning

confidence: 99%

Metabolic liver function after stereotactic body radiation therapy for hepatocellular carcinoma

et al. 2016

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“…Radiation induced liver disease (RILD), previously referred to as "radiation hepatitis", can affect patients 4 to 8 wk after liver exposure to radiation [7][8][9][10][11][12] . RILD is a venoocclusive disorder caused by a direct radiation-induced injury of the liver endothelium [10][11][12] .…”

Section: Case Reportmentioning

confidence: 99%

“…RILD is a venoocclusive disorder caused by a direct radiation-induced injury of the liver endothelium [10][11][12] . This condition can affect 6% to 66% of patients exposed to an excess of 30 to 35 Gy of radiation, depending on the volume of irradiated liver and hepatic functional reserve [10,12] . The typical clinical presentation is a triad of ascites, hepatomegaly and elevated liver enzymes [9] .…”

Section: Case Reportmentioning

confidence: 99%

“…The typical clinical presentation is a triad of ascites, hepatomegaly and elevated liver enzymes [9] . Most patients recover completely after 3 to 5 mo but a minority will progress to a chronic phase, with hepatic fibrosis and liver failure; rare cases of fulminant liver failure have been described [10,12] . The diagnosis essentially emerges from the findings of the typical imaging features on contrast-enhanced computed tomography (CT) and/or magnetic resonance imaging (MRI), affecting the liver in the irradiated field: "straight-border" sign [8] , demarcated areas of hypo or hyper attenuation in a non anatomical distribution (contrasting with vascular lesions) [8] , and alteration of the contrast uptake on CT [13] .…”

Section: Case Reportmentioning

confidence: 99%

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An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease

Cardinale

Filippis

Corsi

et al. 2013

WJH

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We report a case of an isolated hepatic neoplasia which originated in a site of the liver previously affected by radiation induced liver disease (RILD) in a patient resected for gastric cancer and referred to us for high serum alpha-fetoprotein (AFP) levels. This case challenged us in distiguishing, even histologically, between primary liver cancer and AFP producing gastric cancer metastasis. Only a panel of immunohistochemical markers allowed the definitive diagnosis of liver metastasis of endodermal stem cell-derived and AFP producing gastric cancer. We discuss the criteria for a differential diagnosis, as well as the possible link between RILD and emergence of liver neoplasia.

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Diagnostic laparoscopy in radiation-induced liver disease

Cited by 19 publications

References 5 publications

Pathology and images of radiation-induced hepatitis: a review article

Pathology and images of radiation-induced hepatitis: a review article

Metabolic liver function after stereotactic body radiation therapy for hepatocellular carcinoma

An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease

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