Diagnostic Laparoscopy as an Effective Tool in Evaluation of Intra-abdominal Malignancies

Yeola, Meenakshi; Gode, Dilip; Bora, Akshay K

doi:10.5005/jp-journals-10033-1338

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…Patients with suspicious malignancy may not reach the secondary care on time, or they may be reach the wrong specialty [49]. This study is in agreement with Vivek Tiwari et al, A K Dwivedi et al and Mohammed et al [50][51][52] Few other related studies were reported [53][54][55][56][57].…”

Section: Association Of Operative and Pathological Findingssupporting

confidence: 89%

Assessment of the Association between Clinical Examination and Investigations with Outcome in Cases of Abdominal Malignancy

Rashmi

Jajoo

2021

JPRI

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Introduction: Abdominal malignancy is a serious problem in the western world which is presently rising in India due to change in lifestyle. The etiopathogenesis are hereditary, environmental and lifestyle factors. The signs and symptoms vary depending upon the type and stage of cancer. Routine investigations, tumor markers, radiology, endoscopy and biopsy examine patients. There have been advances in chemotherapy, radiotherapy, and palliation but still surgery is curative. Methods: This is a prospective observational study including all cases of abdominal malignancy presenting to Surgery OPD. The sample size is 46 patients. Results: Mean age of presentation is 54.63 years. Preoperative abnormal parameters such as CEA, CA 19-9, preoperative biopsy, lymph nodal metastasis on CT and liver metastasis on CT were correlated with outcome which were found to be significant. Operative findings such as site, area, spread outside serosa, lymph nodal metastasis, and liver metastasis were correlated with same in the radio-pathological findings and were found to be significant. Outcome was assessed. Reasons for delay in presentation, diagnosis and treatment were assessed. Conclusion: Maximum number of patients were in the age group of 41-60 years. There was a definite difference in outcome with reference to preoperative abnormal parameters. There was comparative variation of operative and radio-pathological findings. Study subjects death were due to malignancy as most of them presented to the hospital at advanced stages of malignancy and others dropped out of chemotherapy or radiotherapy and those who took proper treatment had good outcome.

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Section: Association Of Operative and Pathological Findingssupporting

confidence: 89%

Assessment of the Association between Clinical Examination and Investigations with Outcome in Cases of Abdominal Malignancy

Rashmi

Jajoo

2021

JPRI

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“…Surgery and anaesthesia induce shivering as a compensatory mechanism due to thermal dysregulation, which is exacerbated by spinal anaesthesia vasodilatation that redistributes core body heat. We also found in our sample that the number of patients complaining of shivering in the simple Bupivacaine group was significantly high compared to the clonidine group 29. Few studies also reflected on anaesthetics used lower abdominal surgeries [30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

To Determine the Role of Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Lower Abdominal Surgery

Deshmukh¹,

Parate²,

Chandak³

2020

IJFMT

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Background:Clonidine is an alpha-2 adrenergic agonist with various actions, one of which enhances the effectiveness of local anaesthetics. For patients undergoing lower abdominal surgery, we examined the effect of adding intrathecal clonidine to hyperbaric bupivacaine on postoperative pain relief and side effects, if any. Aim:To assess the efficacy of intrathecal clonidine along with hyperbaric Bupivacaine in patients undergoing lower abdominal surgeries.Method: It was a retrospective study carried out under spinal anaesthesia on 80 patients undergoing lower abdominal surgery. The research population was assigned randomly to two groups; group B-received 15 mg bupivacaine+ 0.4mi Normal Saline and group C received 15 mg bupivacaine + 60mcg clonidine.Results: Addition of 60mcgs of intrathecal clonidine to 0.5% hyperbaric bupivacaine significantly prolonged the duration of motor & sensory blockade along with the duration of effective postoperative analgesia. The demand for rescue analgesic was earlier in group B as compared to group C. Both groups were matched for the side-effects like hypotension, bradycardia, nausea, vomiting, and shivering.

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“…An important goal of this technique is to reduce the number of negative laparotomies and reduce the surgical burden in patients who appear to have resectable abdominal masses. This results in reduced perioperative morbidity and mortality, shorter hospital stays, and earlier referral to chemoradiotherapy (Yeola et al, 2018).…”

Section: O M P a R A T I V E S T U D Y O F D N A P L O I D Y A N D B ...mentioning

confidence: 99%

Comparative Study of DNA ploidy and BRAF Immunohistochemistry between Colonic Adenocarcinoma and Inflammatory Colonic Lesions

Khalil

Hammam

Anis

et al. 2023

Asian Pac J Cancer Prev

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Objectives: To evaluate DNA ploidy and S-phase fraction (SPF) in non-Lynch colonic adenocarcinoma, ulcerative colitis (UC), Crohn disease (CD) which are known as risk factors, and colitis. We correlated ploidy and SPF with tumor grading, staging and BRAF expression. Methods: All studied adenocarcinomas have intact mismatch repair genes as proved by immunohistochemistry. All were assessed for ploidy by automated image-based DNA cytometry and histograms were drawn. Immunostaining by anti- BRAF V600E was performed. Diagnostic laparoscopy (DL) was done as a preliminary step for staging GI cancers. Results: there is significant difference in DNA ploidy between groups; 77.5% and 17.5% of aneuploid cases are adenocarcinoma and UC. Groups are compared in terms of 2C, 4C, above 4C DNA content and SPF and significant difference is principally found between adenocarcinoma group and others. In adenocarcinomas, DNA ploidy is significantly correlated with tumor staging and grading. Regarding BRAF expression, there is significant difference between groups; all adenocarcinomas, 83.33% of UC were positive, while all cases of colitis, bilharzial colitis, CD were negative. There is significant relation between BRAF and SPF among all diploid cases including adenocarcinoma, and among non-neoplastic diploid cases. There is direct significant relation between BRAF intensity and adenocarcinoma staging. There is no significant difference between BRAF and ploidy among UC cases, although 75% of aneuploid UC are positive. DL helps in GI cancer staging. Routine laparoscopy before laparotomy, especially in cancers which have equivocal operability helps to avoid unnecessary laparotomies. Conclusion: Based on significant difference in ploidy between adenocarcinoma and UC and between SPF and ploidy, assessment of ploidy by DNA cytometry for UC and other colitis could therefore predict impending malignant transformation before development of colonic dysplasia. Also measuring SPF in adenocarcinoma helps to select patients who could greatly benefit from chemotherapy. DL has vital role in staging GI cancers.

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Diagnostic Laparoscopy as an Effective Tool in Evaluation of Intra-abdominal Malignancies

Cited by 6 publications

References 48 publications

Assessment of the Association between Clinical Examination and Investigations with Outcome in Cases of Abdominal Malignancy

Assessment of the Association between Clinical Examination and Investigations with Outcome in Cases of Abdominal Malignancy

To Determine the Role of Clonidine as an Adjuvant to Intrathecal Bupivacaine in Patients Undergoing Lower Abdominal Surgery

Comparative Study of DNA ploidy and BRAF Immunohistochemistry between Colonic Adenocarcinoma and Inflammatory Colonic Lesions

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