Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version

Abstract

The National Institute of Mental Health developed the semi-structured Diagnostic Interview for Genetic Studies (DIGS) for the assessment of major mood and psychotic disorders and their spectrum conditions. The DIGS was translated into French in a collaborative effort of investigators from sites in France and Switzerland. Inter-rater and test-retest reliability of the French version have been established in a clinical sample in Lausanne. Excellent inter-rater reliability was found for schizophrenia, bipolar disorder, major depression, and unipolar schizoaffective disorder while fair inter-rater reliability was demonstrated for bipolar schizoaffective disorder. Using a six-week test-retest interval, reliability for all diagnoses was found to be fair to good with the exception of bipolar schizoaffective disorder. The lower test-retest reliability was the result of a relatively long test-retest interval that favored incomplete symptom recall. In order to increase reliability for lifetime diagnoses in persons not currently affected, best-estimate procedures using additional sources of diagnostic information such as medical records and reports from relatives should supplement DIGS information in family-genetic studies. Within such a procedure, the DIGS appears to be a useful part of data collection for genetic studies on major mood disorders and schizophrenia in French-speaking populations.

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

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The specificity of the familial aggregation of early-onset bipolar disorder : A controlled 10-year follow-up study of offspring of parents with mood disorders

“…In addition to direct interviews, information on children and parents was systematically elicited from all participants who were at least 15 years old using the Family History-Research Diagnostic Criteria (FH-RDC) (Andreasen et al, 1977). The validity and French translation of the DIGS (Berney et al, 2002;Leboyer et al, 1995;Preisig et al, 1999), the reliability of the K-SADS-E (Chambers et al, 1985;Gammon et al, 1983;Orvaschel et al, 1982;Vandeleur et al, 2012), and the validity of the FH-RDC (Rothen et al, 2009;Rougemont-Buecking et al, 2008;Vandeleur et al, 2008;Vandeleur et al, 2015) have been extensively tested. Interviewers were required to be masters-level psychologists and were trained over a two-month period.…”

Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

“…Diagnosis was made according to the Diagnostic and Statistical Manual (DSM) IV-TR criteria, based on clinical assessment by trained psychiatrists (NP and BP) in addition to using the French version of the Diagnostic Interview for Genetic Studies (DIGS) -a semi-structured interview including a detailed investigation of childhood ADHD and its persistence into adulthood (Preisig et al, 1999). The diagnosis was confirmed for all of the cases by a best estimate procedure.…”