Diagnostic importance of admission platelet volume indices in patients with acute chest pain suggesting acute coronary syndrome

Dehghani, Mohammad Reza; Taghipour-Sani, Leila; Rezaei, Yousef; Rostami, Rahim

doi:10.1016/j.ihj.2014.10.415

Cited by 21 publications

(19 citation statements)

References 21 publications

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“…The reason for the reduced MPV in acute appendicitis is unclear, but the reduced MPV could be due to the consumption or sequestration of the large activated platelets in intestinal vasculature 22 . In addition to sepsis and various infections, MPV also has a positive correlation with many different diseases such as diabetes, myocardial infarction and young children with infections and varying degrees of the cut-off value (8.0–10.35 fL), sensitivity (53–98%) and specificity (35–87%) 23 24 25 26 27 .…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume in young children with urinary tract infection

Lee

Smıth

Park

et al. 2015

Sci Rep

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Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were measured. WBC (P = 0.001), ESR (P = 0.005), CRP (P < 0.001) and MPV levels (P = 0.011) were significantly higher in the APN group than those in the lower UTI group. MPV positively correlated with PDW, CRP and negatively with platelet count. Multiple logistic regression analyses showed that CRP and MPV were independent predictive factors for APN patients. However, the area under the Receiver Operating Characteristic (ROC) curve analysis for MPV was lower than CRP. Our results suggest that MPV can be an inflammatory marker in UTI, but the predictive value of MPV was not superior to CRP in the diagnosis of APN.

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Section: Discussionmentioning

confidence: 99%

Mean platelet volume in young children with urinary tract infection

Lee

Smıth

Park

et al. 2015

Sci Rep

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“…This combined marker has been investigated recently in multiple studies as a marker of more severe atherosclerosis and outcomes after elective and emergency PCI. A high PLT/LYM was associated with more complex CAD in patients with acute coronary syndromes [19,20], and with complete occlusion of the infarct related artery in patients with STEMI [21]. In a recent study a higher incidence of CTO was found in patients with a PLT/LYM greater than 116 [19].…”

Section: Platelet-to-lymphocyte Ratio As An Independent Predictor Of mentioning

confidence: 90%

“…Compared to healthy controls, P-LCR is higher in patients with acute myocardial infarction and unstable angina [12,13]. None of the published studies correlating platelet indices with CAD and especially with STEMI present data on the associations between CTO and P-LCR.…”

Section: Platelet Indices and Ctomentioning

confidence: 99%

“…These observations are in contrast with our findings. It was hypothesized that in patients with acute coronary syndromes the lymphocyte count is lower due to stress-induced cortisol secretion [20]. However, higher cortisol levels would further decrease the production of lymphocytes but already circulating cells could not instantly decrease in numbers.…”

Section: Platelet-to-lymphocyte Ratio As An Independent Predictor Of mentioning

confidence: 99%

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Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Hadadi

Șuș

Lakatos

et al. 2015

Revista Romana De Medicina De Laborator

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Coronary chronic total occlusion (CTO) is caused by organized thrombi or atherosclerotic plaque progression. The presence of a CTO is an independent predictor of mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI). Platelets have a crucial role in the pathophysiology of atherosclerosis. The aim of this retrospective study was to investigate platelet indices as predictors of CTO in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). A total number of 334 patients admitted for STEMI between January 2011 and December 2013 were included and divided in two groups based on the presence of CTO (48 patients in CTO+ group, 286 patients in CTO-group). Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), lymphocyte and neutrophil count determined on admission were analyzed. MPV was larger in patients with CTO compared with patients without CTO (p=0.02), as were PDW (p=0.03) and P-LCR (p=0.01). Platelet-to-lymphocyte ratio (PLT/LYM) was lower in patients with

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“…It could also be used as a marker of platelet reactivity as well as an index for short term mortality of coronary artery disease and the risk of thrombolysis failure [ 11 ]. Further, PDW is considered as a more specific parameter for the activation than MPV, as it does not increase during simple platelet swelling [ [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] ].…”

Section: Introductionmentioning

confidence: 99%

A study of association between platelet volume indices and ST elevation myocardial infarction

Alvitigala

Azra

Kottahachchi

et al. 2018

IJC Heart & Vasculature

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Introduction and objectiveST elevation myocardial infarction (STEMI) is caused by formation of a thrombus at a ruptured atheromatous plaque. Larger platelets are enzymatically and metabolically more active and play a crucial role in thrombus formation. Our objective was to study the association between platelet volume indices (mean platelet volume (MPV) and platelet distribution width (PDW)) and STEMI.MethodsA hospital-based case control study to compare the platelet indices of 52 STEMI patients before commencing antiplatelet therapy and age and gender matched 52 controls who had no history of ischemic heart disease or antiplatelet therapy. Blood samples were collected to EDTA bottles and analyzed using Mindray BC 6800 automated analyzer.ResultsSTEMI patients had significantly increased mean MPV and PDW compared to the control group ((8.22 ± 0.99 fL vs 7.74 ± 0.69 fL, p = 0.005) and (15.81 ± 0.41 fL vs 15.62 ± 0.33 fL, p = 0.007) respectively). Significant positive correlation existed between MPV and PDW (R = 0.556, p = 0.000) and weak negative correlation in platelet count with MPV (R = −0.323, p = 0.019) and PDW (R = −0.309, p = 0.026) of STEMI patients. Receiver Operating Characteristic (ROC) curves showed that MPV and PDW with cutoff values of 7.55 fL, 15.55 fL and with Area under the curve (AUC) of 0.640, 0.620 respectively. The sensitivities and specificities were found to be 73.1%, 69.2% and 61.5%, 55.8% for MPV and PDW respectively.ConclusionIncreased MPV and PDW were found to have a significant association with STEMI and this test has the potential to be used as a preliminary test to identify high-risk patient for myocardial infarction.

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Diagnostic importance of admission platelet volume indices in patients with acute chest pain suggesting acute coronary syndrome

Abstract: An elevated admission MPV, PDW, and P-LCR may be of benefit to detect chest pain resulting in MI from that of non-cardiac one, and also for risk stratification of patients who suffered from an acute chest discomfort.

Cited by 21 publications

References 21 publications

Mean platelet volume in young children with urinary tract infection

Mean platelet volume in young children with urinary tract infection

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

A study of association between platelet volume indices and ST elevation myocardial infarction

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