Diagnostic implications of CZT SPECT and impact of CT attenuation correction

Peters, Andrew C.; Kumar, Jeevan; Patil, Pravin

doi:10.1007/s12350-017-0961-5

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…Bearing in mind that still the ideal radiopharmaceutical for scintigraphic diagnosis of NETs has not been discovered, there are a lot of them under investigation[ 30 - 32 ] such as: 99m Tc-EDDA--tricine-HYNIC-NATE, 99m Tc-EDDA/HYNIC-Tyrosine3-octreotate, 99m Tc-6-hydrazinopyridine-3-carboxylic acid (0)-octreotide or indium-111 (tetraxetan- tyrosine3-octreotate), 99m Tc-demotate or 99m Tc-P829. Wider application of hybrid systems (SPECT/CT, SPECT/MRI) as well as new cadmium-zinc-telluride SPECT and SPECT/CT cameras increased and widened application and increased the accuracy of somatostatin receptor scintigraphy[ 33 , 34 ]. These radiopharmaceuticals can also be used for radio-guided surgery thus increasing sensitivity and specificity of the method[ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Saponjski

Macut

Šobić-Šaranović

et al. 2020

WJCC

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BACKGROUND Neuroendocrine tumors of appendix (ANETs) known as carcinoids, are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal tract. ANETs are the third most frequent (16.7%) gastrointestinal neuroendocrine tumors, with the incidence of 0.08-0.2 cases/100000 during one year. Incidental ANETs occur in 0.2%-0.7% of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of ANET. Although there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors, there are very rare sporadic cases described about ANETs particularly. AIM To establish the role of somatostatin receptor scintigraphy (SRS) in the management of patients with neuroendocrine tumors of appendix (ANET). METHODS The total of 35 patients was investigated, 23 females and 12 males, average age (43.7 ± 17.3 years). All patients had histological diagnosis of ANET (34 carcinoids of appendix and one tubular carcinoid). Majority of tumors have been found incidentally during surgery of: Acute appendicitis ( n = 15), perforated appendicitis ( n = 2), ileus ( n = 3), hysterectomy ( n = 3), ruptured ovarian cyst ( n = 2), caecal volvulus ( n = 1), while 9 patients had diagnosis of appendiceal tumor before the surgery. Seventeen patients had tumor grade (G) G1, 12 G2 and 6 G3. The right hemicolectomy was performed in 13, while the rest of the patients had appendectomy only. SRS was done early (2 h) and late (24 h) after i.v . application of 740 MBq technetium-99m ethylenediamine-N, N'-diacetic acid Hydrazinonicotinyl-Tyr3-Octreotide (technetium-99m-Tektrotyd, Polatom, Poland). SRS was performed for restaging in all the patients after surgery. RESULTS There were 12 true positive (TP), 19 true negative, 3 false positive and 1 false negative SRS result. Sensitivity of the method was 92.31%, specificity was 86.36%, positive predictive value was 80.00%, negative predictive value was 95.00% and accuracy 88.57%. Receiver operating characteristics analysis showed that SRS scintigraphy is a good test for detection TP cases [area under the curve of 0.850, 95% confidence interval (CI): 0.710-0.990, P < 001]. Single photon emission computed tomography contributed diagnosis in 7 TP findings. In 10 patients Krenning score was 4 and in 2 was 3. In 8 patients SRS significantly changed the management of the patients (in two surgery was repeated, in 4 somatostatin analogues and in two peptide receptor radionuclide therapy). Median progression-free survival in SRS positive patients was 52 months (95%CI: 39.7-117.3 mo) while in SRS negative patients it was 60 months (95%CI: 42.8-77.1 mo), without statistically significant differe...

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Section: Discussionmentioning

confidence: 99%

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Saponjski

Macut

Šobić-Šaranović

et al. 2020

WJCC

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“…In the absence of AC, prone position can reduce attenuation artifacts. 6 Recently, it has been demonstrated the possibility to measure MBF and MFR with CZT cameras.…”

Section: See Related Article Pp 755-768mentioning

confidence: 99%

“…Effect of CT attenuation correction on the diagnostic accuracy of CZT-SPECT. This figure is reprinted from Peters et al6 and is licenced under CC BY 4.0.…”

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confidence: 99%

Myocardial perfusion imaging in overweight patients and women: Is it CZT good enough?

Grossman

2020

Journal of Nuclear Cardiology

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“…One of the most common artifacts in MPI is caused by the attenuation of photons by the patient’s body [ 11 ]. Computed tomography-attenuation correction (CT-AC) is a validated approach to improve diagnostic accuracy and risk stratification [ 12 ]. According to the American Society of Nuclear Cardiology’s recommendation, attenuation correction should be performed in all patients [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…The new systems have improved count sensitivity and image quality [ 14 ]. The use of CZT-SPECT in clinical practice is on the rise due to its benefits of enhanced image accuracy and reduced scanning duration compared to conventional SPECT systems using sodium iodide (NaI) crystals [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance

Kalantari,

Mohseninia,

Wetsch

et al. 2023

Life

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Background: Myocardial perfusion imaging (MPI) plays a crucial role in diagnosing coronary artery disease (CAD), with single-photon emission computed tomography (SPECT) being a widely accepted method. The accuracy of MPI relies on image quality and the expertise of physicians. While CZT-SPECT cameras offer advantages, they can be susceptible to attenuation artifacts. Therefore, our objective was to evaluate the diagnostic accuracy of CZT-SPECT and SPECT/CT in a clinical setting. Method: We conducted a prospective single-center study involving patients with known or suspected stable ischemic heart disease who underwent SPECT-MPI using CZT-SPECT and SPECT/CT scanners, and the latter was equipped with cardiofocal collimation. Experienced physicians performed analysis and reporting based on automated quantification and visual image interpretation. Results: A total of 77 patients (32 women (41.6%) and 45 men (58.4%) with an average age of 71.9 ± 8.9 years) were included. The agreement between readers regarding the final conclusion based on imaging reporting using both devices was very high (Kappa 0.87–0.93). Per-vessel analysis revealed a trend suggesting that CZT-SPECT was superior to conventional SPECT/CT in terms of sensitivity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, although the difference did not reach statistical significance. Conclusion: Our study demonstrated that CZT-SPECT imaging offers comparable diagnostic accuracy, improved patient comfort, and eliminates CT-induced radiation compared to SPECT/CT. These findings suggest that cardiac CZT-SPECT imaging has the potential to become a valuable imaging modality in clinical practice.

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Diagnostic implications of CZT SPECT and impact of CT attenuation correction

Cited by 4 publications

References 24 publications

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

Myocardial perfusion imaging in overweight patients and women: Is it CZT good enough?

Head-to-Head Comparison of CZT-SPECT and SPECT/CT Myocardial Perfusion Imaging: Interobserver and Intraobserver Agreement and Diagnostic Performance

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