Diagnostic histological features of metastatic lymph nodes in adenosquamous carcinoma

Immunohistochemical and HPV-related features of laryngeal adenosquamous carcinoma

“…Radical surgery with neck dissection is the treatment of choice for head and neck ASC [11]. Analyzing 12 cases of their own and another 46 previously described in the literature, Keelawat et al [7] compared the survival rates of patients treated with surgery as opposed to surgery plus postoperative radio-chemotherapy.…”

“…Keelawat et al [7] performed unilateral selective neck dissections in 3 patients with laryngeal ASC, and bilateral procedures in 2 (bilateral selective neck dissection in one, and selective plus modified radical neck dissection in the other). Mokhtari et al [11] treated their laryngeal ASC patient with bilateral radical neck dissection. Adjuvant treatments were administered in 66% of the cases of laryngeal ASC with available data: radio-chemotherapy in 39%, radiotherapy alone in 22%, and chemotherapy alone in 5% [4,6,7,11-13].…”

Laryngeal adenosquamous carcinoma: A population‐based perspective

“…Adenosquamous carcinoma (ASC) of the head and neck is an exceedingly rare tumor, with less than an estimated 100 cases having been reported in the aerodigestive tract . The most commonly involved site is the larynx . Laryngeal ASC (LASC) is associated with a better prognosis than ASC affecting other areas of the body .…”

“…Unlike MEC, however, the squamous cell and adenocarcinoma portions of ASC are distinct and separate, without any evidence of mixing. Furthermore, ASC of the head and neck is more aggressive, with a reported 5‐year survival rate between 13% and 25%, whereas MEC has a reported 5‐year survival rate of 92%, 63%, and 27% for low‐, intermediate‐, and high‐grade disease, respectively …”

Oral squamous cell carcinoma with pseudo-glandular differentiation

“…When it occurs in the minor salivary glands, it usually grows beneath the surface epithelium without breaching it or only infiltrating it subsequently (6). Several histological characteristics helpful in distinguishing mucoepidermoid carcinoma from adenosquamous SCC are absence of dysplastic overlying epithelium, lobular arrangement and presence of intermediate cells (1,6,9,10,16). In addition, mucus cells and intraepithelial and ductal sialomucins are readily recognized in mucoepidermoid carcinoma which is not the case here (10).…”