Diagnostic Exercise

Foster, Aiden P; Twomey, D. F.; Monie, O. R.; Kiupel, Matti; Hoffmann, Ines; Willoughby, Kim

doi:10.1177/0300985810363574

Cited by 14 publications

(26 citation statements)

References 11 publications

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“…The distribution and the type of inflammation without presence of intralesional organisms narrowed the differential diagnoses considerably. Because the inflammation was vasocentric and the lesions were similar to that of a previous report of OvHV-2 dermatitis in a goat, 3 OvHV-2 was a plausible cause.…”

Section: Further Investigations and Diagnosissupporting

confidence: 81%

“…OvHV-2 infection does occur in goats, 4,5,7 though cases of dermatitis are infrequently reported. 3 This case demonstrates that OvHV-2 can cause dermatitis in goats. Vasotropism, which is a classic lesion of OvHV-2 MCF in cattle, was a feature of the dermatitis in this goat.…”

Section: Discussionmentioning

confidence: 77%

“…Vasotropism, which is a classic lesion of OvHV-2 MCF in cattle, was a feature of the dermatitis in this goat. 3,5 Because the gross presentation is not specific, OvHV-2-associated dermatitis in goats may be underdiagnosed, since it is not typically among the differential diagnoses of caprine dermatitis. 1 However, if goats are known to be in close proximity to sheep, and if common dermatitides are ruled out, then testing for OvHV-2 should be considered.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Challenge in Veterinary Pathology: Alopecic Crusting Dermatitis in a Goat

et al. 2021

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In April 2020, a 1-year-old castrated Nigerian dwarf goat presented with a 4-month history of skin lesions unresponsive to topical iodine and extra-label topical miconazole. The wether was bright, alert, and with normal appetite. The goat was the only affected animal in a mixed herd of 7 sheep and 4 goats aged from 6 months to 7 years. The animals were kept on a dry lot and fed strictly timothy and alfalfa hay with access to goat minerals (Purina ® ).The goat had multifocal alopecia with fissures, erosions, crusting, and scaling that predominated on the ventrum (Fig. 1). The cutaneous lesions were nonpruritic, firm, raised, moderately demarcated, and nonpigmented.

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Section: Further Investigations and Diagnosissupporting

confidence: 81%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Diagnostic Challenge in Veterinary Pathology: Alopecic Crusting Dermatitis in a Goat

et al. 2021

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“…The lack of infectivity is likely because the virus remains cell-associated in these species; thus, cell-free viruses are not produced. Though the majority of cases of OvHV-2 infection in goats appears to be subclinical, reports have associated OvHV-2 infection in goats with various clinical symptoms, including corneal opacity and pyrexia with neurological signs [ 30 31 ]. Further research is required to elucidate the effect of OvHV-2 on the health and productivity of goats and determine whether goats can act as a reservoir animal and be a source of OvHV-2 infection in susceptible animals.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection and characterization of ovine herpesvirus-2 using heminested PCR in Pakistan

et al. 2021

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Background Malignant catarrhal fever (MCF) is a highly fatal lymphoproliferative disease of cattle, deer, bison, water buffalo, and pigs caused by the gamma-herpesviruses alcelaphine herpesvirus-1 (AlHV-1) and ovine herpesvirus-2 (OvHV-2). Objectives This study aimed to determine the prevalence of OvHV-2 in sheep, goats, cattle, and buffalo in Rawalpindi and Islamabad, Pakistan, by applying molecular and phylogenetic methods. Methods Blood samples were aspirated from sheep (n = 54), goat (n = 50), cattle (n = 46) and buffalo (n= 50) at a slaughterhouse and several farms. The samples were subjected to heminested polymerase chain reaction (PCR), followed by sequencing and phylogenetic analysis of the OvHV-2 POL gene and the OvHV-2 ORF75 tegument protein gene. Results The highest percentage of MCF positive samples was in sheep (13%), whereas goat, cattle, and buffalo had lower positive percentages, 11%, 9%, and 6.5%, respectively. Four OvHV-2-positive PCR products obtained from sheep samples were sequenced. The sequences obtained were submitted to the NCBI GenBank database (MK852173 for the POL gene; MK840962, MK852171, and MK852172 for the ORF75 tegument protein gene). Phylogenetic analysis revealed a close similarity of study sequences with those of worldwide samples. Conclusions This study is the first cross-sectional study on the prevalence and molecular detection of OvHV-2 in apparently healthy cattle and buffalo that could be carrying OvHV-2 acquired from OvHV-2-positive sheep and goats. The results indicate that OvHV-2 is circulating in Pakistan. Further studies are needed to characterize OvHV-2 and elucidate further its prevalence.

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“…It is usually associated with presumed adverse cutaneous drug reactions. A single case was reported in a goat infected with ovine herpesvirus-2 2) . The purpose of this article is to report a second case of granulomatous mural folliculitis in a goat.…”

Section: Introductionmentioning

confidence: 99%

Presumed Sterile Eosinophilic and Granulomatous Mural Folliculitis and Furunculosis in an Angora and Pygmy Crossbreed Goat

et al. 2019

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Presumed sterile eosinophilic and granulomatous mural folliculitis and furunculosis was diagnosed in a goat. Dermatological findings included widespread, nonpruritic, bilaterally symmetrical exudation, crusting, alopecia, and thickened skin. Infectious causes were ruled out by negative histochemical stains and negative PCR for ovine herpesvirus-2 conducted on skin-biopsy specimens. There was a 50% reduction in the severity of the dermatitis with intramuscular injections of dexamethasone. A cause for the skin condition was not determined.

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Diagnostic Exercise

Cited by 14 publications

References 11 publications

Diagnostic Challenge in Veterinary Pathology: Alopecic Crusting Dermatitis in a Goat

Diagnostic Challenge in Veterinary Pathology: Alopecic Crusting Dermatitis in a Goat

Molecular detection and characterization of ovine herpesvirus-2 using heminested PCR in Pakistan

Presumed Sterile Eosinophilic and Granulomatous Mural Folliculitis and Furunculosis in an Angora and Pygmy Crossbreed Goat

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