Diagnostic Evaluation of the Lupus Band Test in Discoid and Systemic Lupus Erythematosus

George, Renu; Kurian, Susy; Jacob, Molly; Thomas, Kurian

doi:10.1111/j.1365-4362.1995.tb01560.x

Cited by 39 publications

(24 citation statements)

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“…[1][2][3][4][5][6][7] For the demonstration of immunoreactant deposition in the skin, using other techniques apart from direct immunofluorescence (DIF) on fresh tissue and/or tissue fixed in physiologic fixative is not well established. However, in kidney biopsy specimens, performing immunohistochemical (IH) assessment of complement deposition on paraffinembedded tissue is of great diagnostic value.…”

mentioning

confidence: 99%

The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease

Magro

Dyrsen

2008

Journal of the American Academy of Dermatology

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confidence: 99%

The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease

Magro

Dyrsen

2008

Journal of the American Academy of Dermatology

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“…Therefore, skin biopsies were obtained in most patients several years after disease onset, during the remission phase of their renal disease. The sensitivity of the Lupus Band Test in SLE has been reported to be as high as 93%, with a specificity of 87% [26]. Other authors have reported a positivity rate of 58% in a group of 90 SLE patients, although 87% of those with renal involvement had positive skin immunofluorescence [21].…”

Section: Discussionmentioning

confidence: 96%

Usefulness of skin immunofluorescence for distinguishing SLE from SLE-like renal lesions: a pilot study

et al. 2010

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Lupus nephritis (LN) may represent a diagnostic problem, particularly in pediatric patients that present with typical histological lesions but do not fulfill the American Rheumatism Association (ARA) criteria for the diagnosis of systemic lupus erythematosus (SLE). Based on the well-described deposition of immunoglobulins (Ig) and complement at the dermoepithelial junction in SLE, we hypothesized that skin biopsies may help in the diagnosis of LN. To test this hypothesis, we carried out a pilot study, performing a skin biopsy in 22 patients with LN and 13 patients with lupus-like lesions, regardless of the time elapsed from onset of renal disease. The latter group of patients was further divided into a purely renal group, designated as isolated full-house nephropathy (FHN), and a dubious cases group, presenting with additional clinical and biological features consistent with SLE but insufficient for diagnosing SLE. None of the 6 isolated FHN patients had positive skin immunofluorescence. Conversely, 5/7 patients in the dubious cases group (p<0.02) and 13/22 in the LN group (p<0.002) had positive staining for C1q, and 5/7 patients in the dubious cases group (p<0.02) and 16/22 patients in the LN group (p<0.001) had positive staining for IgM. No correlation was observed with the time elapsed from the initial diagnosis. These data suggest that skin biopsies may help distinguishing LN from isolated FHN. In addition, they identify an intermediate group of patients with evidence of systemic involvement despite the absence of a sufficient number of ARA criteria to be labeled as SLE.

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“…64 The high positivity of this test makes it the most sensitive for lupus, but it is not the most specific, since these antibodies may be detected in other autoimmune or infectious diseases or even in The presence of immunoglobulins in lupus lesions and in lesion-free skin from non-sun-exposed areas has shown a range of results. 9,54,56,57 Sugai et al, 10 analyzed 71 patients with DLE and found 66.2% positive lesions; they raise the possibility that in earlier studies patients with SCLE or SLE had been included, which would account for a higher incidence of positive results for direct immunofluorescence. Prystowsky et al, 9 in a group of 80 patients, assessed 17 DLE patients, and had positive DIF for lesioned skin in 77%, whereas in 31 patients in whom cutaneous fragments collected from normal, non-sunexposed areas, were analyzed, no deposit of immunoglobulin was found.…”

Section: Serologic Testsmentioning

confidence: 99%

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

Berbert

Mantese

2005

An. Bras. Dermatol.

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Lupus erythematosus is a connective tissue autoimmune disorder that demonstrates systemic, cutaneous, or both systemic and cutaneous manifestations. Cutaneous lesions are classified as specific and nonspecific. The variety of clinical manifestations of the disease is reflected in the broad spectrum of laboratory patterns. In this article we describe the distinct subsets of cutaneous lupus erythematosus, correlating them with histopathological, direct immunofluorescence and serological findings. Keywords: Skin diseases; Autoimmune diseases; Collagen diseases; Connective tissue diseases; Lupus erythematosus, Cutaneous/classification; Lupus erythematosus, Cutaneous/diagnosis. Resumo: O lúpus eritematoso é doença auto-imune do tecido conjuntivo que reúne manifestações exclusivamente cutâneas ou multissistêmicas, podendo apresentar exuberância de auto-anticorpos. As lesões cutâneas do lúpus eritematoso são polimorfas e podem ser específicas ou inespecíficas. A diversidade de manifestações clínicas da doença reflete-se no amplo espectro de achados laboratoriais. Este artigo descreve as variadas formas clínicas do lúpus eritematoso cutâneo correlacionan

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Diagnostic Evaluation of the Lupus Band Test in Discoid and Systemic Lupus Erythematosus

Abstract: The high negative predictive value of LBT in SLE suggests that it is valuable in excluding diseases clinically similar to SLE.

Cited by 39 publications

References 12 publications

The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease

The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease

Usefulness of skin immunofluorescence for distinguishing SLE from SLE-like renal lesions: a pilot study

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

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